Prempro 0.3/1.5 costs up to $400 without insurance. Learn how to save with coupons, discount cards, patient assistance programs, and other money-saving tips.
Let's not sugarcoat it: Prempro 0.3/1.5 28 Day is one of the pricier hormone replacement therapy (HRT) medications on the market. Without insurance, you could be looking at $330 to $400 per month for a single 28-day blister pack. That's over $4,000 a year just for one medication.
The good news? There are real ways to lower your out-of-pocket cost—whether you have insurance or not. Here's everything you need to know about saving money on Prempro 0.3/1.5 in 2026.
The average retail (cash) price for Prempro 0.3/1.5 28 Day is approximately $365 for 28 tablets. Prices can vary by pharmacy, with some locations charging as much as $400 and others as low as $330.
Here's a quick price comparison:
Because there is no generic version of Prempro, you won't find a cheaper generic equivalent at the pharmacy counter. This makes discount strategies especially important.
Prescription discount cards are one of the easiest ways to reduce the cost of Prempro 0.3/1.5. These cards are free and work at most major pharmacies. Here are some of the best options:
SingleCare offers Prempro 0.3/1.5 28 Day for as low as $237—a savings of over $125 off the average cash price. The coupon is free and accepted at over 35,000 pharmacies including CVS, Walgreens, Walmart, and Rite Aid.
GoodRx provides free coupons that can bring the price of Prempro 0.3/1.5 down to approximately $240–$280 depending on your pharmacy. Prices vary by location, so it's worth checking multiple pharmacies on the GoodRx website or app.
Several other free discount card programs may offer additional savings:
Pro tip: Prices vary significantly between pharmacies and between discount programs. Check 2–3 different discount cards and compare prices at multiple pharmacies before filling your prescription. A few minutes of comparison shopping can save you $50–$100 per fill.
Pfizer, the maker of Prempro, may offer savings programs for eligible patients:
If you have commercial (non-government) insurance, Pfizer may offer a copay savings card that can reduce your out-of-pocket cost to as little as $25–$50 per month. These cards typically cannot be used with Medicare, Medicaid, or other government-funded insurance.
Check the Prempro product website or Pfizer RxPathways for current offers and eligibility requirements.
If you're uninsured or underinsured and meet income eligibility requirements, patient assistance programs can provide Prempro at no cost or significantly reduced cost.
Pfizer RxPathways is Pfizer's patient assistance hub. It connects eligible patients with programs that can provide Prempro for free. Eligibility is typically based on household income (often up to 400% of the federal poverty level) and insurance status.
NeedyMeds is a nonprofit that maintains a comprehensive database of patient assistance programs, discount drug programs, and other resources. Search for "Prempro" on their site to find all available programs.
RxAssist is another resource that helps patients find assistance programs. It provides a searchable directory of pharmaceutical company programs, government programs, and nonprofit resources.
RxHope helps patients apply directly to manufacturer patient assistance programs. Your doctor may need to help complete the application.
If you have insurance, check whether Prempro is on your plan's formulary and what tier it falls on. Some tips:
Many insurance plans offer lower copays for 90-day mail-order supplies compared to 30-day retail fills. If you're taking Prempro long-term, a 90-day mail-order prescription can save both money and the hassle of monthly pharmacy visits.
If cost is a major barrier, talk to your doctor about whether a less expensive alternative might work for you. Generic Activella (estradiol/norethindrone acetate) costs approximately $30–$80 per month—a fraction of Prempro's price. Read our alternatives guide for more options.
If you have a Flexible Spending Account (FSA) or Health Savings Account (HSA), Prempro is an eligible expense. Using pre-tax dollars effectively gives you a 20–35% discount depending on your tax bracket.
Some states offer prescription assistance programs for residents who don't qualify for Medicaid but still need help with medication costs. Check with your state's department of health or aging services.
Prempro 0.3/1.5 28 Day doesn't have to cost you $400 a month. Between discount cards (saving you $100+ per fill), manufacturer savings programs, patient assistance programs, and insurance optimization strategies, there are real pathways to affordable access.
Start by checking prices with a free discount card like SingleCare or GoodRx, then explore Pfizer's savings and assistance programs. And don't forget to use Medfinder to find pharmacies with Prempro in stock—because the best price doesn't help if the medication isn't on the shelf.
You focus on staying healthy. We'll handle the rest.
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