How to Save Money on Praluent in 2026: Coupons, Discounts, and Patient Assistance

Praluent (alirocumab) is one of the most effective cholesterol-lowering medications available, but its price reflects that — without insurance or a savings program, two prefilled pens cost approximately $533–$777 per month. The good news: multiple programs exist to significantly reduce what you actually pay. Here's a complete guide to every money-saving option available in 2026.

What Does Praluent Actually Cost?

Praluent pricing varies by dose, pharmacy, and whether you're using insurance or a discount program:

Cash price without discounts: ~$533–$777 per month for two prefilled pens (75 mg or 150 mg)

Annual list price: ~$5,850/year at the list price Sanofi established after a 60% price reduction in 2018

With commercial insurance: Varies widely; prior authorization required; copay depends on plan tier

With GoodRx coupon (cash pay): As low as $225 for 2 pens — roughly 65% off average retail price of ~$636

Praluent is a biologic medication with no generic or biosimilar equivalent available in the US as of 2026 — so the brand price is what everyone is working with. Savings programs are essential.

Option 1: MyPRALUENT Copay Card (For Commercially Insured Patients)

The MyPRALUENT Copay Card is the most impactful savings option for most commercially insured patients. Provided by Regeneron:

Eligible patients may pay as little as $35–$50 per month for deductibles, copays, and coinsurance

Maximum program savings: $3,500 per year

No income requirements to qualify

Not valid for Medicare, Medicaid, VA, DOD, or TRICARE beneficiaries

How to apply: Call 1-844-772-5836 or visit praluent.com/starting-and-paying-for-praluent-rx. Have your insurance information ready. Enrollment is quick and the card can be used at your specialty pharmacy.

Option 2: MyPraluent Patient Assistance Program (For Uninsured/Underinsured)

For patients without adequate insurance coverage and with limited income, Regeneron's Patient Assistance Program (PAP) may provide Praluent at no cost:

Eligible uninsured or underinsured patients may receive Praluent at no charge for up to 12 months, renewable

Income restrictions apply (contact the program for current thresholds)

Enroll via phone: 1-844-PRALUENT (1-844-772-5836) or online at praluent.com

Your doctor or a staff member at their office can also help submit the PAP enrollment form on your behalf.

Option 3: GoodRx Coupons (For Cash-Pay Patients)

GoodRx offers Praluent for as low as $225 for 2 pens at participating pharmacies — a discount of approximately 65% from the average retail price of $636. GoodRx coupons are used as cash-pay discounts and cannot be combined with insurance.

GoodRx is most useful when you're between insurance coverage periods, have a high deductible plan, or when the cash-pay price is lower than your insurance copay. Present the GoodRx coupon at any participating pharmacy along with your prescription.

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Option 4: Medicare Part D Savings for Medicare Patients

Medicare patients face some unique challenges: the MyPRALUENT Copay Card is not valid for Medicare beneficiaries under federal law. However, there are still options:

Part D $2,100 annual out-of-pocket cap (2026): Once you hit this cap, your plan covers your medications at 100% for the rest of the calendar year — including Praluent if it's covered by your plan.

Extra Help / Low-Income Subsidy (LIS): If your income and assets are below certain thresholds, you may qualify for Extra Help, which limits your Part D deductible and copays significantly.

MyPraluent PAP for Medicare patients: If you don't have Part D coverage for Praluent and meet income requirements, the PAP may still provide assistance. Contact 1-844-772-5836 for details.

Maximizing Your Savings: Practical Tips

Enroll in the copay card or PAP before your first fill — not after you've paid full price

Ask your doctor's office if they have samples available for bridge coverage while waiting for PA approval

If starting at 75 mg q2wk, your doctor may titrate up to 150 mg q2wk — starting at the lower dose reduces annual costs by roughly 20–30%

Compare your out-of-pocket cost under the copay card vs. GoodRx — occasionally GoodRx is lower

If you're also struggling to find Praluent in stock after sorting out cost, medfinder can help locate pharmacies near you that have your medication available. Provide your drug, dosage, and location and medfinder calls local pharmacies on your behalf.

For more help on locating Praluent, see our guide on how to find Praluent in stock near you.