How to Save Money on Polymyxin B/Trimethoprim in 2026: Coupons, Discounts, and Patient Assistance

Good news for patients prescribed Polymyxin B/Trimethoprim (Polytrim): this antibiotic eye drop is already one of the more affordable prescription options for bacterial conjunctivitis. A 10 mL bottle is all you need for a full 7–10 day course. Even without insurance, the cost is manageable — and with the right discount tools, you can reduce it significantly.

What Does Polymyxin B/Trimethoprim Cost Without Insurance?

The retail cash price for a 10 mL bottle of generic polymyxin B/trimethoprim ophthalmic solution varies by pharmacy, but typically falls in the range of $12–$32. The brand-name version (Polytrim) can cost more. Here's what discount programs bring it down to:

GoodRx: As low as $5.46 for the generic version (62% off the average retail price of ~$14.39). The Polytrim brand can be found for as low as $2.46 with GoodRx at select pharmacies.

SingleCare: Approximately $9.97 for a 10 mL bottle with a SingleCare coupon at major pharmacies.

Drugs.com price guide: Lists polymyxin B/trimethoprim starting from approximately $10.07 for a 10 mL bottle depending on pharmacy and region.

How to Use a GoodRx or SingleCare Coupon

Search for your drug on GoodRx.com or SingleCare.com (or download their app).

Enter 'Polymyxin B/Trimethoprim' and your zip code.

Compare prices at nearby pharmacies.

Show the coupon (print, email, or app) to your pharmacist when picking up the prescription.

Important: you cannot use a GoodRx coupon at the same time as insurance. Compare which is lower — often the coupon price beats your insurance copay for inexpensive generics.

What Does Insurance Cover for Polymyxin B/Trimethoprim?

Most commercial insurance plans cover generic polymyxin B/trimethoprim ophthalmic solution as a Tier 1 or Tier 2 generic drug, meaning your copay is usually quite low — often $0–$15 depending on your plan. Medicare Part D also typically covers this medication. Medicaid coverage varies by state but generally includes it on the formulary.

Because the drug is already a low-cost generic, insurance or discount coupons tend to produce similar results. It's worth comparing both to see which gets you to the lowest price at the pharmacy nearest to you.

Is There a Manufacturer Savings Program?

Formal manufacturer patient assistance programs (PAPs) or copay savings cards are not typically available for low-cost generics like polymyxin B/trimethoprim. These programs are usually offered for expensive brand-name drugs. Since the generic version of this eye drop is already priced under $10–$15 with discount coupons, third-party discount cards like GoodRx or SingleCare are your best and most practical savings tools.

Tips to Keep Costs Down

Always request generic: Ask your prescriber to write for the generic (polymyxin B sulfate/trimethoprim sulfate) rather than brand-name Polytrim.

Compare pharmacy prices: Prices for the same drug can vary by $10–$20 between pharmacies. GoodRx and SingleCare both allow you to compare prices before choosing where to fill.

Don't skip the coupon just because you have insurance: For low-cost generics, discount card prices often match or beat the insurance copay. Always compare.

Avoid buying more than you need: A single 10 mL bottle is enough for a full 7–10 day course at 6 drops per day. You don't need to stock up.

The Bottom Line

Polymyxin B/Trimethoprim is one of the more affordable antibiotic eye drops available. Even without insurance, using a GoodRx or SingleCare coupon can get the price under $10. Your biggest challenge in 2026 isn't cost — it's finding it in stock. See our guide on how to find Polymyxin B/Trimethoprim in stock near you for strategies to locate it quickly.