How to Save Money on Mefloquine in 2026: Coupons, Discounts, and Patient Assistance

Mefloquine is not a cheap medication. At standard retail prices, a course of mefloquine for a typical 8-week trip can cost $90-$120 or more without insurance. But with the right discount tools, you can significantly reduce that cost — often paying under $35 for the same medication. Here's what you need to know.

What Does Mefloquine Typically Cost?

Retail prices for generic mefloquine 250 mg tablets vary considerably by pharmacy. Based on 2025-2026 pricing data:

Average retail price: Approximately $90-$120 for 8 tablets (an 8-week prophylaxis course)

With GoodRx coupon: As low as $32.83 — a 71-73% discount off the average retail price

With SingleCare coupon: As low as $22.44 per 4 tablets (approximately $44 for an 8-week course)

With Medicare: Some Medicare Part D plans cover mefloquine with copays around $28 — comparable to or less than GoodRx pricing

Note: These prices reflect the generic formulation only. The brand-name Lariam was discontinued in the U.S. in 2009 and is not available domestically.

How to Use GoodRx for Mefloquine

GoodRx is one of the most widely used prescription discount programs and can reduce mefloquine costs significantly. Here's how to use it:

Visit GoodRx.com or download the GoodRx app

Search for "mefloquine 250 mg"

Enter your zip code to see prices at pharmacies near you

Present the GoodRx coupon (digital or printed) to the pharmacist at checkout — instead of using your insurance

Important: GoodRx coupons cannot be combined with insurance. At the pharmacy, you'll use either your insurance OR the GoodRx coupon — whichever is cheaper. For mefloquine, GoodRx is often less expensive than standard insurance copays, especially if mefloquine is placed on a higher formulary tier.

How to Use SingleCare for Mefloquine

SingleCare offers a prescription savings card that can reduce mefloquine to as low as $22.44 per 4 tablets at participating pharmacies. Like GoodRx, SingleCare is free to use and does not require insurance. Visit SingleCare.com, search for mefloquine, and show the savings card at your pharmacy.

Does Insurance Cover Mefloquine?

Coverage varies by plan. Generic mefloquine may be covered as a Tier 1 or Tier 2 medication on some plans, but it is not universally covered. Travel medications (including antimalarials) are sometimes classified differently from maintenance medications, and some plans require the medication to be for a covered indication.

To check your coverage:

Call the member services number on your insurance card and ask about coverage for mefloquine hydrochloride 250 mg (generic)

Check your plan's drug formulary online (search for "mefloquine" or "antimalarial")

Compare your insurance copay to GoodRx or SingleCare pricing — if the coupon is cheaper, use the coupon

Is There a Patient Assistance Program for Mefloquine?

No manufacturer patient assistance program (PAP) is currently available for mefloquine from Teva. Unlike many brand-name drugs (which often have copay cards or PAPs), generic medications rarely have manufacturer assistance programs. The best savings options remain GoodRx, SingleCare, and similar pharmacy discount programs.

Tips to Maximize Your Savings

Compare prices at multiple pharmacies: GoodRx and SingleCare pricing varies by pharmacy location. The same prescription can cost very differently between CVS, Walgreens, and Costco.

Fill a larger quantity: If your trip is 10-12 weeks, ask your prescriber for a 90-day supply. Per-tablet cost is often lower when buying more.

Consider Costco pharmacy: Costco pharmacies consistently offer low medication prices, often comparable to or better than GoodRx pricing. Non-members can use the pharmacy in many states.

Check RxSaver, Blink Health, and NeedyMeds: These are additional discount platforms that sometimes offer lower prices on specific drugs than GoodRx.

The Bottom Line

You don't have to pay full retail price for mefloquine. GoodRx and SingleCare can reduce your cost by 70-80%, bringing an 8-week course of mefloquine down to $33-44. Check whether your insurance beats that, and use whichever is cheaper. If you're also struggling to find mefloquine in stock, medfinder can help locate it at pharmacies near you. See our guide: How to Find Mefloquine In Stock Near You.