Leucovorin Can Be Expensive — But There Are Ways to Save

Leucovorin Calcium is a critical medication used in cancer treatment and methotrexate rescue therapy. If you're paying out of pocket or dealing with high copays, the cost can add up quickly — especially during a shortage when prices fluctuate. The good news is that several programs and strategies can help you save money on Leucovorin in 2026.

In this guide, we'll break down what Leucovorin costs, where to find the best prices, and how to access financial assistance if you need it.

How Much Does Leucovorin Cost Without Insurance?

The cost of Leucovorin depends on the formulation, dosage, and where you fill your prescription:

• Generic Leucovorin oral tablets (5 mg, 12 tablets): The average cash price is approximately $36, though prices vary by pharmacy.
• With a discount card: GoodRx prices start around $24.45 for 12 tablets of 5 mg. SingleCare offers comparable savings, bringing the price to roughly $25-$30.
• Injectable formulations: Prices range widely from $30 to over $500 depending on the vial size (50 mg to 500 mg). Injectable Leucovorin is typically administered in a clinic or hospital and billed under your medical benefit, not your pharmacy benefit.
• Brand Wellcovorin: Significantly more expensive than generic. Without insurance, brand-name pricing can be substantially higher.

During a shortage, prices can be even more unpredictable. Pharmacies with limited stock may charge higher prices, making it especially important to comparison-shop.

Coupons and Discount Cards

Prescription discount cards are one of the easiest ways to save on Leucovorin tablets. Here are the top options:

GoodRx

GoodRx offers coupons that can bring the price of generic Leucovorin tablets down to around $24-$25 at participating pharmacies. GoodRx Gold members may pay as little as $10 for certain quantities. Simply search for Leucovorin on goodrx.com, compare prices at nearby pharmacies, and show the coupon at pickup.

SingleCare

SingleCare provides similar savings, with prices averaging around $25-$36 for 12 tablets of 5 mg. You can use SingleCare at most major pharmacies including CVS, Walgreens, and Walmart.

Other Discount Programs

Several other discount card programs may offer competitive pricing:

• RxSaver: Compare prices across pharmacies at rxsaver.com
• Optum Perks: Search for deals at perks.optum.com
• BuzzRx: Free discount card accepted at most pharmacies
• ScriptSave WellRx: Price comparison and coupons at wellrx.com

Prices vary by pharmacy and change frequently, so it's worth checking multiple programs before filling your prescription.

Patient Assistance Programs

If you're uninsured, underinsured, or facing financial hardship, patient assistance programs (PAPs) can provide Leucovorin at significantly reduced cost or even free:

Prescription Hope

Prescription Hope works with pharmaceutical companies to provide medications to qualifying patients for a flat fee of $70 per month. They list Wellcovorin (brand Leucovorin) in their program. Enrollment requires demonstrating financial need.

Pfizer RxPathways

Since Pfizer manufactures brand Wellcovorin, their RxPathways program may offer assistance for eligible uninsured or underinsured patients. The program connects patients with savings cards, co-pay assistance, and free medication programs depending on income level.

NeedyMeds

NeedyMeds (needymeds.org) maintains a database of patient assistance programs, including those covering Leucovorin. You can search by drug name to find current programs, eligibility requirements, and application information.

RxAssist

RxAssist (rxassist.org) is another comprehensive directory of pharmaceutical company patient assistance programs. It includes programs for both brand and generic medications.

Other Ways to Save on Leucovorin

Ask for Generic

Generic Leucovorin Calcium is available and significantly cheaper than brand Wellcovorin. Always ask your pharmacist to fill with the generic version unless your doctor has specifically prescribed the brand. Generic Leucovorin is therapeutically equivalent to the brand-name product.

Compare Pharmacy Prices

Prices for the same medication can vary dramatically from one pharmacy to the next — sometimes by 50% or more. Use tools like Medfinder and GoodRx to compare prices in your area. Don't assume your usual pharmacy has the best price.

Try Independent Pharmacies

Independent pharmacies sometimes offer lower cash prices than chains because they have different overhead costs and may work with different wholesalers. They're also often more willing to work with you on pricing.

Check Your Insurance Benefits Carefully

Leucovorin may be covered differently depending on how it's administered:

• Oral tablets: Usually covered under your pharmacy benefit (Part D for Medicare).
• Injectable (administered in clinic): Typically covered under your medical benefit (Part B for Medicare).

Understanding which benefit covers your Leucovorin can help you maximize your coverage and minimize out-of-pocket costs. If your plan requires prior authorization for brand Wellcovorin, your doctor's office can submit the paperwork.

Ask About 340B Pricing

If you receive treatment at a 340B-eligible hospital or clinic (many safety-net hospitals and federally qualified health centers qualify), you may benefit from significantly reduced drug pricing through the federal 340B program. Ask your treatment center if they participate.

What About the Injectable Form?

If you receive Leucovorin by injection at an infusion center or hospital, the cost is typically handled differently than oral prescriptions:

• Injectable Leucovorin is usually billed as part of your treatment and covered under your medical insurance.
• Your out-of-pocket cost depends on your plan's deductible, coinsurance, and out-of-pocket maximum.
• If you're uninsured, ask the billing department about financial assistance programs — most hospitals have charity care or sliding-scale fee programs.

Final Thoughts

No one should have to choose between affording their medication and staying on their treatment plan. Between discount cards (which can bring Leucovorin tablets down to around $24), patient assistance programs (like Prescription Hope at $70/month), and smart pharmacy shopping, there are real ways to reduce what you pay for Leucovorin in 2026.

Start by checking prices on Medfinder and comparing discount programs. If you're struggling with costs, reach out to NeedyMeds or RxAssist to find assistance programs you may qualify for.

For more information about this medication, see our guides on what Leucovorin is, the current shortage situation, and how to find it in stock near you.