Isentress costs up to $2,500/month without insurance. Learn how to save with coupons, discount cards, and patient assistance programs in 2026.
Isentress (Raltegravir) is a critical HIV medication — but it's also an expensive one. Without insurance, Isentress can cost between $1,900 and $2,500 per month for a 30-day supply. That's roughly $23,000 to $30,000 per year out of pocket.
If you're struggling with the cost of Isentress, you're not alone. In this guide, we'll walk you through every way to save money on Isentress in 2026, from manufacturer coupons to patient assistance programs and beyond.
Here's what you can expect to pay for Isentress at retail prices in 2026:
These prices reflect cash prices without any insurance, coupons, or discount programs applied. The actual amount you pay will depend on your pharmacy, location, and whether you use any of the savings options below.
As of early 2026, there is no widely available generic version of Raltegravir, which keeps prices high. Lupin Ltd received FDA approval for a generic in May 2025, but the generic has not yet reached most pharmacies.
Prescription discount cards can significantly reduce what you pay for Isentress, especially if you're uninsured or your insurance doesn't cover it. Here are the main options:
GoodRx offers coupons for Isentress that can bring the price down to approximately $1,944 at participating pharmacies. Prices vary by location and pharmacy, so compare options on goodrx.com.
SingleCare provides free discount cards accepted at most major pharmacies. Check singlecare.com/prescription/isentress for current pricing at pharmacies near you.
RxSaver (by RetailMeNot) compares prices across pharmacies and provides printable or digital coupons. Visit rxsaver.com to search for Isentress pricing.
Optum Perks offers discounts on Isentress at participating pharmacies. Check perks.optum.com for current offers.
BuzzRx provides a free prescription discount card that can be used at over 60,000 pharmacies nationwide. Visit buzzrx.com for Isentress pricing.
Important note: Discount cards cannot be combined with insurance. They're most useful for uninsured patients or situations where the cash price with a coupon is lower than your insurance copay.
Merck, the manufacturer of Isentress, offers a copay savings card for commercially insured patients. Here are the details:
This card can reduce your monthly copay to $0 or close to it depending on your plan's cost-sharing structure. If your insurance copay for Isentress is $200/month, the Merck card would cover that entirely.
If you're uninsured or can't afford Isentress even with insurance, patient assistance programs (PAPs) can provide the medication for free.
Merck's PAP is the primary assistance program for Isentress:
The SUPPORT Program goes beyond just providing free medication. It helps patients:
If you're living with HIV and meet income requirements, your state's AIDS Drug Assistance Program (ADAP) may cover Isentress at no cost to you. ADAP is part of the Ryan White HIV/AIDS Program and is available in all 50 states. Contact your local Ryan White program or HIV case manager to apply.
These nonprofit databases help you find additional assistance programs:
If you're on Medicare, the $2,000 annual out-of-pocket cap on Part D prescription costs (effective since 2025) means your total spending on Isentress and other Part D drugs is capped. Once you hit $2,000 in out-of-pocket costs for the year, you pay $0 for the rest of the year.
Lupin Ltd received FDA approval for generic Raltegravir in May 2025. While it's not widely available yet, check with your pharmacy periodically — when the generic does reach the market, it could cost significantly less than brand-name Isentress.
If cost is a major barrier, talk to your doctor about alternatives that may be more affordable:
Read more about your options in our guide on alternatives to Isentress.
If you receive care at a 340B-eligible facility (such as a federally qualified health center, Ryan White clinic, or certain hospital outpatient departments), you may be able to access Isentress at significantly reduced 340B pricing through the facility's pharmacy.
Some insurance plans offer lower copays for medications filled through their preferred mail-order specialty pharmacy. Check with your insurer to see if mail-order fills reduce your out-of-pocket cost for Isentress.
No one should have to skip their HIV medication because of cost. Between manufacturer programs, insurance coverage, government assistance, and discount cards, there are multiple ways to bring the cost of Isentress down — in many cases to $0 per month.
Start by checking if you qualify for the Merck copay card or patient assistance program, and use tools like Medfinder to find Isentress at the best price near you. If cost remains a barrier, talk to your doctor about affordable alternatives.
For more information about Isentress, explore our guides on what Isentress is, Isentress side effects, and Isentress drug interactions.
You focus on staying healthy. We'll handle the rest.
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