How to Save Money on Entrectinib in 2026: Coupons, Discounts, and Patient Assistance

Entrectinib (brand name Rozlytrek) is one of the most expensive oral cancer drugs on the market. Without insurance or financial assistance, a 28-day supply costs approximately $8,000. There is no FDA-approved generic. But there are several legitimate programs that can bring your cost down significantly — or even to zero. Here's everything you need to know in 2026.

How Much Does Entrectinib Cost Without Insurance?

The full cash price for Rozlytrek is approximately $8,000 per 28-day supply for adult patients taking the standard 600 mg once-daily dose. Since adults typically take three 200 mg capsules (or six 100 mg capsules) per day, a one-month supply requires 90 or more capsules. At retail rates from specialty pharmacies, this works out to roughly $8,000/month or approximately $96,000/year. There is currently no generic alternative available.

Option 1: Genentech Oncology Co-pay Assistance Program

This is the most powerful cost-reduction tool available for commercially insured patients. Eligible patients may pay $0 out of pocket for Rozlytrek, with Genentech covering up to $25,000 in costs per product per calendar year. To qualify, you must:

Have commercial (non-government) insurance that covers Rozlytrek

Be a U.S. resident

Not be enrolled in a federal or state healthcare program (Medicare, Medicaid, Tricare, VA)

Contact Genentech Access Solutions at 877-436-3683 to enroll. Your oncologist's office can also initiate enrollment on your behalf.

Option 2: Genentech Patient Foundation (Free Drug for Qualifying Patients)

The Genentech Patient Foundation provides Rozlytrek at no charge to patients who are uninsured, underinsured, or who cannot otherwise afford their medication. Qualification is based on income and insurance status. Your oncologist can submit an application on your behalf by contacting Genentech Access Solutions (877-436-3683).

Option 3: Independent Co-pay Assistance Foundations

If you are on Medicare or Medicaid and don't qualify for Genentech's commercial co-pay program, independent nonprofit foundations may be able to help. Genentech Access Solutions can refer you to the right organizations. Options include:

CancerCare Co-Payment Assistance Foundation — provides grants for cancer drug copays

Patient Access Network Foundation (PANF) — assists patients with coverage gaps and high out-of-pocket costs

HealthWell Foundation — provides assistance for patients with serious chronic illnesses

The Leukemia and Lymphoma Society — available for hematologic cancer patients

Option 4: Medicare Extra Help (Low Income Subsidy)

If you're on Medicare Part D with a low income, you may qualify for Medicare Extra Help (also called the Low Income Subsidy or LIS). This federal program significantly reduces your Part D premiums and cost-sharing for specialty drugs like Rozlytrek. Ask your oncologist's social worker or contact the Social Security Administration at 1-800-772-1213 to apply.

Are There Coupons or GoodRx Discounts for Rozlytrek?

Because Rozlytrek is a specialty medication with no generic version, traditional drug discount programs like GoodRx do not typically offer meaningful discounts. Rozlytrek is available only through specialty pharmacies, which don't accept standard discount cards. The most effective cost-reduction strategy remains Genentech's manufacturer co-pay program or the independent foundations listed above.

Tips to Maximize Your Savings

Enroll in Genentech's copay program before your first fill, not after you've paid out of pocket

Ask your oncologist if you qualify for a clinical trial that provides the drug at no cost

Track the calendar-year cap on co-pay assistance ($25,000/year) and plan for what happens when it resets in January

Ask your social worker about state pharmaceutical assistance programs (SPAPs) if you're on Medicare and your income is above Extra Help limits but you still can't afford the copay

The Bottom Line

The $8,000/month cost of Rozlytrek is daunting, but most commercially insured patients and many uninsured patients can access significant financial assistance through Genentech and independent foundations. Start the conversation with your oncologist's office and Genentech Access Solutions (877-436-3683) before your first fill. And if you're having trouble finding a specialty pharmacy that can fill your prescription, medfinder can help by contacting pharmacies near you. See also our guide to finding entrectinib in stock near you.