How to Save Money on Anusol HC in 2026: Coupons, Discounts, and Patient Assistance

Anusol HC can be surprisingly expensive, especially for the brand-name version. The brand-name 12-suppository box has been priced as high as $900 at retail — far out of reach for most patients without insurance coverage. The good news: generic equivalents and discount programs can bring the cost dramatically lower. Here's how to get Anusol HC (or its equivalent) at the lowest possible price in 2026.

What Does Anusol HC Actually Cost?

Prices vary widely depending on whether you're getting the brand or generic, and which form you need:

• Brand-name Anusol HC 25 mg suppositories (12 count): Up to $903.90 at full retail price.
• Generic hydrocortisone acetate suppositories (12 count): From $33.71 at major pharmacies.
• Generic hydrocortisone acetate 2.5% cream (30g): Starting from $12.10 with discount cards (GoodRx prices start at $16.79, SingleCare as low as $12.10).

The bottom line: if you're paying full price for brand-name Anusol HC, you're very likely overpaying. Here are the best ways to reduce your cost.

Tip 1: Ask for the Generic

This is the single most effective way to reduce your Anusol HC cost. Generic hydrocortisone acetate suppositories (Anucort-HC, Proctocort) and generic hydrocortisone acetate 2.5% cream (Proctosol-HC, Proctozone HC) contain the same active ingredient as brand-name Anusol HC and meet the same FDA standards. The cost difference can be enormous — sometimes $800 or more for a 12-suppository supply.

If your prescription says "Anusol HC" without "dispense as written," ask your pharmacist to fill the generic. If it does say "dispense as written," ask your doctor to change it to allow generic substitution.

Tip 2: Use a Prescription Discount Card

Prescription discount cards are free and can dramatically lower your cost at the pharmacy, even if you have insurance:

• GoodRx: Prices for generic hydrocortisone rectal cream start at $16.79. Free to use at over 70,000 pharmacies. Download the app or print a coupon at GoodRx.com.
• SingleCare: Generic Anusol HC cream (30g) as low as $12.10 at participating pharmacies. Free program, no membership needed.
• Optum Perks: Available at pharmacies nationwide, can save up to 80% on Anusol HC with coupons.
• RxSaver, NeedyMeds, Blink Health: Compare prices across discount programs — prices vary by pharmacy, so comparing a few services can save additional money.

Important: You cannot use a discount card at the same time as insurance. Compare your insurance copay vs. the discount card price, and pay whichever is lower.

Tip 3: Check Your Insurance Coverage

If you have insurance, generic hydrocortisone acetate rectal is typically covered on Tier 1 or Tier 2 formularies with low copays ($0-$30 for generic on most commercial plans). Brand-name Anusol HC may be on a higher tier or require step therapy.

Medicare Part D plans generally cover generic hydrocortisone rectal products. The 2026 Part D out-of-pocket cap is $2,100, providing a safety net if you use multiple medications.

Tip 4: Use Mail-Order Pharmacy for 90-Day Supplies

If you use Anusol HC or a generic equivalent on an ongoing basis for a chronic condition, mail-order pharmacies often provide 90-day supplies at lower per-unit costs than retail pharmacies. Express Scripts, CVS Caremark, and OptumRx all offer mail-order services, often with additional cost savings compared to monthly retail fills.

Tip 5: Explore Manufacturer Programs (Limited for Generic Drugs)

Salix Pharmaceuticals (the brand-name manufacturer) does not currently publicize a patient assistance program specifically for Anusol HC on their website. However, the generic alternatives (Anucort-HC, Proctosol-HC) are already inexpensive with discount cards, which makes manufacturer assistance programs less necessary than for higher-cost specialty drugs.

For patients who are truly unable to afford any option, NeedyMeds.org maintains a database of patient assistance programs and low-cost clinics that may be able to help.

Tip 6: Try OTC 1% Hydrocortisone Cream (With Your Doctor's OK)

For mild hemorrhoid symptoms and external anal itching, over-the-counter 1% hydrocortisone cream (Preparation H Hydrocortisone, Cortizone-10) may provide adequate relief. This option is dramatically cheaper — typically under $10 at any drugstore — and doesn't require a prescription.

However, OTC 1% products are less potent than prescription 2.5% cream or 25 mg suppositories, and are not appropriate for more significant internal rectal inflammation. Always check with your doctor before switching from a prescription strength to OTC.

Quick Cost Summary for 2026

• Generic cream (30g, no coupon): $17-$50
• Generic cream with GoodRx/SingleCare: $12-$17
• Generic suppositories (12 count): From $33-$50
• With insurance (generic): $0-$30 copay
• OTC 1% hydrocortisone cream: Under $10

If you're also having trouble finding Anusol HC in addition to cost concerns, medfinder can help you locate it at pharmacies near you. See also: How to Find Anusol HC in Stock Near You.