How to Help Your Patients Save Money on Onfi: A Provider's Guide to Savings Programs

For neurologists and providers caring for patients with Lennox-Gastaut syndrome (LGS), Onfi (clobazam) cost is a recurring barrier to care. Brand-name Onfi retails at $745–$1,000+ per month at many pharmacies, and even generic clobazam can cost $30–$150 per month. For families managing a complex, lifelong epilepsy syndrome — often with multiple medications, frequent appointments, and significant caregiver burden — these costs can be prohibitive.

As a prescriber, you're in a critical position to connect patients with savings resources and to make prescribing decisions that lower costs without compromising care. This guide covers the most effective strategies for reducing your patients' Onfi costs in 2026.

1. Prescribe Generic Clobazam by Default

The most impactful prescribing decision you can make for cost is to prescribe clobazam generically rather than as brand-name Onfi. Generic clobazam is FDA-approved as therapeutically equivalent to Onfi and available from multiple manufacturers. The price difference is dramatic:

• Brand Onfi: $745–$1,000+ per month at retail
• Generic clobazam: $30–$150 per month at cash price; $18–$90 with discount cards

Unless there is a specific clinical reason to prescribe brand (e.g., documented intolerance of a specific generic excipient), clobazam generic is the appropriate default. Be sure your prescription does not include "Dispense as Written" unless medically necessary, as this forces brand dispensing.

2. Recommend Prescription Discount Cards to Your Patients

For uninsured or underinsured patients, and even for some insured patients whose copay exceeds the discount card price, prescription discount cards can substantially reduce the cost of generic clobazam:

• GoodRx: Pricing as low as $26.20 for generic clobazam (96% off retail). GoodRx Gold membership reduces this further to ~$21.13. Accepted at most major chains and many independent pharmacies.
• SingleCare: Pricing as low as $18.35 for generic clobazam. Accepted at CVS, Walgreens, Walmart, and most major pharmacies.
• RxSaver: Aggregates prices across programs; useful for comparison.

A simple after-visit note or patient handout pointing patients to goodrx.com or singlecare.com takes seconds but can save hundreds of dollars per month.

3. Lundbeck Patient Assistance Program (for Uninsured/Underinsured Patients)

Lundbeck, the manufacturer of brand-name Onfi, operates a patient assistance program (PAP) that provides the medication at no cost to eligible patients. As the prescriber, your office plays an important role in this process:

• Eligibility typically requires: U.S. residency, no or inadequate prescription coverage, and income below approximately 300–400% of the federal poverty level
• A provider signature and medical necessity documentation is required
• Contact Lundbeck Support: 1-800-455-1141 or download the PAP form from onfi.com

Lundbeck can also assist with prior authorization support, bridge supply during PA appeals, and provider education resources. This is especially relevant when patients on generic clobazam need brand Onfi or Sympazan.

4. Aquestive Therapeutics Programs (for Sympazan)

For patients prescribed Sympazan (the oral film formulation of clobazam), Aquestive Therapeutics offers patient assistance and copay support programs. Sympazan is particularly important for patients who cannot swallow tablets and for whom the oral suspension is unavailable. Contact Aquestive's patient support directly for eligibility details and enrollment assistance.

5. Insurance Optimization and Prior Authorization Strategy

For insured patients, a few prescribing and billing strategies can reduce cost:

• 90-day supplies: Many insurance plans offer a lower per-dose copay for 90-day fills via mail order or preferred retail pharmacies. For patients on stable clobazam regimens, write for 90-day supplies where state controlled substance laws permit.
• Prior authorization appeals: If brand Onfi or Sympazan is denied, file a PA appeal with clinical justification. Document: LGS diagnosis, treatment history showing need for specific formulation, and clinical response. Lundbeck's support team (1-800-455-1141) provides PA appeal assistance.
• Formulary exceptions: If the standard formulary tier results in unaffordable copays, request a formulary exception citing medical necessity. LGS patients often qualify given the limited medication options approved for this rare condition.

6. Nonprofit and Community Resources for Your Patients

Several nonprofit resources can help patients navigate clobazam costs when other options are insufficient:

• Epilepsy Foundation: Provides a helpline (1-800-332-1000), medication assistance grants, and connections to local chapter resources.
• NeedyMeds (needymeds.org): Comprehensive database of PAPs, drug discount cards, and state-based programs. Patients can search for clobazam specifically.
• RxAssist (rxassist.org): Another searchable database of patient assistance programs from pharmaceutical manufacturers.

7. Using medfinder to Address Both Cost and Access

Cost is inseparable from access — a patient who can afford their clobazam but can't find it in stock is still at risk. medfinder is a service that calls pharmacies near patients to find which ones have their medication in stock. Directing patients to medfinder addresses the access problem that affects many LGS families, especially those who rely on generic clobazam — which, despite being affordable, can be intermittently unavailable at chain pharmacies.

A Quick Reference for Your Practice

Here's a summary of actions your office can take:

• Prescribe generic clobazam (not brand Onfi) as default
• Include GoodRx.com / SingleCare.com in patient education materials
• Enroll eligible patients in Lundbeck's PAP (1-800-455-1141)
• Write 90-day supplies for stable patients where DEA/state rules allow
• File PA appeals with Lundbeck support when brand is needed
• Direct patients to medfinder when they have trouble finding the medication in stock