How to Help Your Patients Save Money on Ogsiveo: A Provider's Guide to Savings Programs

As the prescribing oncologist or care team member for a desmoid tumor patient, you play a central role in not just choosing the right therapy, but in helping your patient actually afford and access it. At a list price of approximately $25,000–$30,000 per month, Ogsiveo (nirogacestat) requires active navigation of financial assistance programs. The good news: SpringWorks Therapeutics has invested in a comprehensive support ecosystem, and most patients who are enrolled in the right programs can receive Ogsiveo at dramatically reduced — or no — cost.

This guide provides a detailed breakdown of every savings program available for Ogsiveo in 2026, with practical guidance on how to enroll your patients in each.

Overview: SpringWorks CareConnections

All Ogsiveo financial assistance is coordinated through SpringWorks CareConnections — the manufacturer's patient support program. CareConnections serves as a single point of contact for:

Benefits verification and insurance navigation

Prior authorization submission and appeal support

Commercial copay program enrollment

Patient assistance program applications

Bridge supply programs

Dedicated nurse advocate assignment for ongoing support

Contact: 1-844-CARES-55 (1-844-227-3755) | springworkstxcares.com. The enrollment form can be submitted by your office or downloaded and initiated by the patient. Initiating enrollment at the time of prescribing — rather than waiting for the first fill — is the highest-yield action your team can take to ensure your patient receives timely access.

Program 1: Commercial Copay Program (for Commercially Insured Patients)

This is the most widely applicable program and often the most impactful for your patient population.

Eligibility: Commercially insured patients (not Medicare or Medicaid). No income requirements.

Benefit: Out-of-pocket cost reduced to as little as $0 per prescription.

Limitations: Subject to annual benefit maximum; terms and conditions apply. Cannot be used with Medicare, Medicaid, or other federal health programs.

How to enroll: Enroll through CareConnections at the time of prescribing. Patient can also self-enroll online at springworkstxcares.com.

Remind patients to re-enroll at the start of each calendar year, as copay assistance programs often reset annually.

Program 2: Patient Assistance Program (PAP) (for Uninsured/Underinsured)

For patients who are uninsured, underinsured, or whose insurance does not cover Ogsiveo:

Eligibility: Uninsured or underinsured patients meeting income eligibility criteria.

Benefit: Free Ogsiveo for eligible patients.

Required documentation: Income verification, prescription, and medical documentation. Oncologist's signature and attestation required.

How to enroll: Initiate through CareConnections. Your office will need to provide clinical documentation, and the patient will need to provide income verification. CareConnections nurse advocates can guide both parties through the process.

Program 3: Quick Start Program (Bridge for PA Delays)

For commercially insured patients whose insurance decision is pending:

Benefit: Initial 30-day supply + 1 refill provided at no cost while PA is being processed.

Best use case: When your patient needs to start treatment urgently and you've submitted the PA but haven't received approval yet.

Enroll via: CareConnections at 1-844-CARES-55.

Program 4: Gap Coverage Program (Bridge for Coverage Lapses)

For patients experiencing a lapse in insurance coverage (job loss, transition between plans):

Benefit: Initial 30-day supply + up to 2 refills at no cost during the coverage gap.

Best use case: When a patient loses their job (and insurance) mid-treatment, or is transitioning between commercial plans with a temporary coverage gap.

Enroll via: CareConnections at 1-844-CARES-55.

Program 5: Independent Charitable Foundations

Independent charitable foundations — not affiliated with SpringWorks — may provide additional financial support, particularly for Medicare patients who are ineligible for manufacturer copay programs. These foundations may offer:

Copay assistance for Medicare Part D patients

Premium support

Travel and other ancillary cost support

CareConnections nurse advocates can identify which foundations currently have open enrollment for desmoid tumor patients. Your social worker or patient navigator may also have current information on available foundation resources.

Building a Savings Workflow Into Your Practice

The most effective practices treat financial assistance enrollment as part of the prescribing workflow — not an afterthought. Consider implementing:

A standard handoff to your financial navigator or social worker at the time of Ogsiveo prescribing

A standing CareConnections enrollment process run by your prior authorization team

A calendar reminder for patients each January to re-enroll in the commercial copay program

Proactive insurance change screening — patients who switch jobs or insurance plans mid-year may need bridge programs

For help with the pharmacy access side of the equation, medfinder for providers can call pharmacies to help locate Ogsiveo in stock on your patient's behalf. And for a full guide to managing access logistics, see our article on how to help your patients find Ogsiveo in stock.