How to Find a Doctor Who Can Prescribe Ambrisentan (Letairis) Near You [2026 Guide]

Ambrisentan (Letairis) is not a medication that any doctor can simply call in to a pharmacy. Because it is used for pulmonary arterial hypertension (PAH) — a rare, complex, and life-threatening condition — it is prescribed almost exclusively by specialists who have the expertise to diagnose PAH and manage its treatment. And because it has a REMS program, prescribers must meet specific requirements before writing for it. Here is what you need to know about finding the right doctor in 2026.

Who Can Prescribe Ambrisentan?

Any licensed prescriber (MD, DO, NP, PA) can technically prescribe ambrisentan, but they must be certified in the Ambrisentan REMS program to prescribe it to females of reproductive potential. More importantly, diagnosing and treating PAH requires specific expertise and access to testing that most primary care providers do not have.

In practice, ambrisentan is prescribed by:

Pulmonary Hypertension Specialists: The gold standard. These are usually pulmonologists or cardiologists with dedicated subspecialty training in PAH. They have access to the right heart catheterization required to confirm the diagnosis.

Pulmonologists: Lung specialists who manage PAH as part of their practice. Especially appropriate if your PAH is related to an underlying lung condition.

Cardiologists: Heart specialists who manage PAH, especially when the condition has significant cardiac involvement (e.g., right heart failure).

Rheumatologists: Sometimes prescribe ambrisentan for connective tissue disease-associated PAH (e.g., in scleroderma patients), often working in partnership with a PAH specialist.

Nurse Practitioners and Physician Assistants: In PAH specialty practices, NPs and PAs often manage ongoing ambrisentan prescriptions for established patients under physician supervision.

Why Your Primary Care Doctor Typically Cannot Diagnose PAH

Diagnosing PAH (WHO Group 1) requires a right heart catheterization — an invasive procedure performed in a cardiac catheterization lab. This test measures pulmonary arterial pressure directly and is the gold standard for confirming PAH and ruling out other forms of pulmonary hypertension. Primary care physicians typically do not perform this test and are not trained to interpret it in the PAH context.

If your doctor suspects PAH based on symptoms such as progressive shortness of breath, fatigue, dizziness, or leg swelling, they should refer you to a PAH specialist or a pulmonary hypertension center for definitive diagnosis.

How to Find a PAH Specialist Near You

Finding a qualified PAH specialist is the critical first step. Here are the best resources:

Pulmonary Hypertension Association (PHA) Care Center Network: phassociation.org lists PHA-accredited pulmonary hypertension care centers, which are academic or hospital-based programs with dedicated PAH expertise. These are the most comprehensive treatment centers in the U.S.

Ask your primary care doctor for a referral: Request a referral to a pulmonologist or cardiologist at an academic medical center or large hospital system. These settings are most likely to have dedicated PAH programs.

LEAP provider locator: The Gilead LEAP program can help patients connect with physicians familiar with Letairis/ambrisentan. Call 1-866-664-5327.

Physician finders through board certification: Search for board-certified pulmonologists (American Board of Internal Medicine) or cardiologists at the ABIM website or through your insurance plan's provider directory.

Telehealth and Ambrisentan Prescribing

Telehealth has expanded access to specialty care for PAH patients, especially for follow-up visits once a diagnosis has been established and treatment is stabilized. However, initial diagnosis of PAH requires in-person evaluation and right heart catheterization — these cannot be done via telehealth.

For established patients on ambrisentan, telehealth visits for medication management, symptom assessment, and REMS compliance monitoring (e.g., pregnancy test results for female patients) may be appropriate depending on the practice and state regulations. Ask your PAH specialist if telehealth follow-up is available.

What to Expect at Your First PAH Appointment

Your first visit with a PAH specialist will typically include a thorough medical history, physical exam, echocardiogram, pulmonary function tests, and a six-minute walk test. If PAH is suspected, a right heart catheterization will be scheduled. Bring all prior medical records, imaging, and a complete list of current medications.

Once prescribed, if you ever have trouble filling your ambrisentan prescription, medfinder can help you find it at pharmacies near you. For more information about the medication itself, see our guide to what ambrisentan is and how it works.