Comprehensive medication guide to Adempas including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$100/mo/month
Estimated Cash Pricing
$14,000–$15,000/mo/month
Medfinder Findability Score
35/100
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Adempas (riociguat) is a prescription medication manufactured by Bayer used to treat two forms of pulmonary hypertension:
Both conditions involve dangerously high blood pressure in the arteries of the lungs, which forces the heart to work harder and can lead to heart failure. Adempas helps relax and widen these blood vessels to reduce the strain on the heart and improve blood flow.
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![How to Find a Doctor Who Can Prescribe Adempas Near You [2026 Guide]](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2Fvur4atr4%2Fproduction%2Faec8aba836e2252e7056718b681805534f4ce577-1024x1024.png%3Frect%3D0%2C256%2C1024%2C512%26w%3D400%26h%3D200%26auto%3Dformat&w=828&q=75)
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0.5 mg tablets
1 mg tablets
1.5 mg tablets
2 mg tablets
2.5 mg tablets
Like all medications, Adempas can cause side effects. The most commonly reported include:
Serious side effects to watch for include:
The gradual dose titration schedule (starting at 1 mg TID and increasing slowly) is designed to minimize blood pressure-related side effects. Report any concerning symptoms to your doctor promptly.
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Nitrates
moderateIncluding nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, and recreational "poppers" (amyl nitrite). The combination can cause life-threatening drops in blood pressure.
PDE-5 inhibitors
moderateIncluding sildenafil (Viagra, Revatio), tadalafil (Cialis, Adcirca), and vardenafil (Levitra). These drugs work on the same pathway and the combination causes excessive hypotension.
Other sGC stimulators
moderateNo other soluble guanylate cyclase stimulators should be combined with Adempas.
Strong CYP and P-gp/BCRP inhibitors
moderateDrugs like ketoconazole and ritonavir can significantly increase Adempas blood levels.
Antacids
moderateAluminum/magnesium hydroxide antacids can reduce Adempas absorption; take them at least one hour apart.
Smoking
moderateTobacco smoking reduces Adempas blood levels; dose adjustments may be needed when starting or stopping smoking.
Antihypertensives
moderateOther blood pressure-lowering medications may have additive effects.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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