Alternatives to Caplyta If You Can't Fill Your Prescription

If you've been prescribed Caplyta (Lumateperone) but can't find it at your pharmacy — or the cost is too high — you may be wondering what other options are available. The good news is that there are several medications in the same drug class that treat similar conditions.

Important: Never switch medications on your own. Always talk to your doctor before making any changes to your treatment plan. This article is for informational purposes only.

What Is Caplyta and How Does It Work?

Caplyta is an atypical antipsychotic approved by the FDA for three conditions in adults:

• Schizophrenia
• Bipolar depression (bipolar I or II)
• Major depressive disorder (as an add-on to antidepressants)

Caplyta works by modulating three key neurotransmitter systems in the brain: serotonin, dopamine, and glutamate. This multi-target approach is part of what makes Caplyta unique — and why some patients respond well to it when other medications haven't worked.

It's taken as a single 42 mg capsule once daily, with or without food. Many patients and doctors appreciate that Caplyta tends to have a lower risk of weight gain and metabolic side effects compared to older atypical antipsychotics. For a deeper dive, see our article on how Caplyta works.

Why You Might Need an Alternative

There are several reasons patients look for Caplyta alternatives:

• Availability: Caplyta can be hard to find at local pharmacies.
• Cost: Without insurance, Caplyta costs $1,650 to $1,800 per month, and not all plans cover it.
• Side effects: Some patients experience dizziness, sedation, or dry mouth that makes Caplyta difficult to tolerate.
• Insurance requirements: Many plans require trying other medications through step therapy before covering Caplyta.

4 Alternatives to Caplyta

1. Latuda (Lurasidone)

Latuda is one of the closest alternatives to Caplyta. It's FDA-approved for both schizophrenia and bipolar depression in adults. A generic version (Lurasidone) is available, which makes it significantly more affordable — often under $50 per month with a coupon card.

Key differences from Caplyta:

• Must be taken with at least 350 calories of food for proper absorption
• Available in multiple dose strengths (20 mg, 40 mg, 60 mg, 80 mg, 120 mg)
• Not approved for MDD as an adjunctive therapy
• Common side effects include nausea, akathisia (restlessness), and sedation

2. Vraylar (Cariprazine)

Vraylar is another atypical antipsychotic with a broad range of approvals. It's FDA-approved for schizophrenia, bipolar depression, and bipolar mania/mixed episodes. It has a unique long half-life, meaning it stays in your system longer.

Key differences from Caplyta:

• Available in capsule form (1.5 mg, 3 mg, 4.5 mg, 6 mg)
• Also a brand-name medication with no generic available
• Costs roughly $1,400 to $1,700 per month without insurance
• Common side effects include akathisia, insomnia, and weight gain

3. Rexulti (Brexpiprazole)

Rexulti is FDA-approved for schizophrenia and as an adjunctive treatment for MDD. If you were prescribed Caplyta for depression, Rexulti may be a reasonable alternative to discuss with your doctor.

Key differences from Caplyta:

• Not approved for bipolar depression
• Brand-name only, with costs similar to Caplyta (around $1,400 to $1,600 per month)
• Common side effects include weight gain and akathisia
• Taken once daily, with or without food

4. Seroquel (Quetiapine)

Seroquel has been available for over two decades and has a generic version (Quetiapine), making it one of the most affordable options. It's FDA-approved for schizophrenia, bipolar depression, bipolar mania, and as an adjunctive treatment for MDD.

Key differences from Caplyta:

• Available in immediate-release and extended-release formulations
• Generic Quetiapine can cost as little as $10-$30 per month
• Higher risk of sedation, weight gain, and metabolic side effects
• Requires dose titration (starting low and increasing gradually)

How to Choose the Right Alternative

The best alternative depends on your specific condition, side effect concerns, insurance coverage, and treatment history. Here are some questions to discuss with your doctor:

• Which of my conditions does the alternative treat?
• What are the most likely side effects?
• Is a generic version available?
• Will my insurance cover it without prior authorization?

Your doctor can help weigh the pros and cons based on your unique situation.

Final Thoughts

While Caplyta is a valuable medication for many patients, it's not the only option. Latuda, Vraylar, Rexulti, and Seroquel are all real alternatives worth discussing with your provider. If cost or availability is your main concern, generic Lurasidone or Quetiapine may be the most practical choice.

If you'd still like to try finding Caplyta, use Medfinder to check pharmacy availability near you. And for tips on reducing the cost, see our guide on how to save money on Caplyta.