Comprehensive medication guide to Rocklatan including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$30–$100 copay depending on your plan's tier; Tier 3–4 (non-preferred brand) on most commercial formularies. Prior authorization is commonly required. Eligible commercially insured patients may pay as little as $30 via the Alcon Savings Card.
Estimated Cash Pricing
$450–$482 retail for the brand-name 2.5 mL bottle (one month's supply); as low as $345–$364 with GoodRx or SingleCare coupons. No generic is available as of 2026.
Medfinder Findability Score
55/100
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Rocklatan (netarsudil and latanoprost ophthalmic solution 0.02%/0.005%) is a prescription eye drop manufactured by Alcon and FDA-approved in March 2019. It is indicated for the reduction of elevated intraocular pressure (IOP) in adults with open-angle glaucoma or ocular hypertension.
Rocklatan is the only FDA-approved fixed-dose combination of a Rho kinase (ROCK) inhibitor and a prostaglandin F2α analog. It combines two active ingredients — netarsudil 0.02% (previously marketed alone as Rhopressa) and latanoprost 0.005% (the most widely prescribed glaucoma eye drop in the world, available generically as Xalatan) — into a single once-daily evening drop.
Rocklatan is a brand-only medication with no generic equivalent as of 2026. Patent protections are expected to remain in place until approximately 2034.
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Rocklatan lowers intraocular pressure through four distinct and complementary mechanisms, making it uniquely comprehensive compared to single-mechanism glaucoma drops.
Netarsudil (ROCK inhibitor) lowers IOP by: (1) increasing aqueous humor drainage through the trabecular meshwork by relaxing and unclogging this primary drainage canal; (2) reducing aqueous humor production by the ciliary body; and (3) lowering episcleral venous pressure by dilating episcleral veins, which allows aqueous to flow more freely out of the eye.
Latanoprost (prostaglandin analog) lowers IOP by increasing aqueous outflow through the secondary uveoscleral pathway — relaxing the smooth muscle and connective tissue in this route to allow more fluid to escape. In the MERCURY 1 and MERCURY 2 Phase 3 trials, Rocklatan reduced IOP by 1–3 mmHg more than either component alone, with more than 60% of patients achieving ≥30% IOP reduction.
0.02%/0.005% — ophthalmic solution
One drop in affected eye(s) once daily in the evening. Single 2.5 mL multi-dose dropper bottle.
Rocklatan is not on the FDA or ASHP drug shortage list as of 2026, but patients frequently experience difficulty finding it at local pharmacies. Its brand-only status, high retail price ($450–$482 per bottle), refrigeration requirements, and insurance prior authorization hurdles all contribute to inconsistent pharmacy stocking. Many pharmacies simply don't carry it unless there's consistent local demand.
Large chain pharmacies (CVS, Walgreens, Costco) are your best bet for in-store stock. Mail-order pharmacies through your insurance plan offer the most consistent supply. Most retail pharmacies can special-order Rocklatan in 1–2 business days if it's not on the shelf.
Rather than calling pharmacies one by one, use medfinder — a service that contacts pharmacies near you to find which ones can fill your Rocklatan prescription and texts you the results.
Rocklatan is not a controlled substance and requires no special DEA authorization to prescribe. Any licensed prescriber with authority to write ophthalmic prescriptions may prescribe Rocklatan. However, because it is used for glaucoma and ocular hypertension — conditions requiring IOP measurement and optic nerve monitoring — it is almost always prescribed by eye care specialists.
Telehealth prescribing of Rocklatan is limited because glaucoma requires in-person IOP measurement and optic nerve assessment. Established patients with existing prescriptions may be able to get refills via telehealth ophthalmology platforms in some states, but new patients will need an in-person eye examination.
No. Rocklatan is not a controlled substance and is not scheduled by the DEA. It has no abuse potential and can be prescribed by any licensed prescriber with authority to write ophthalmic prescriptions — including ophthalmologists, optometrists (in most states), nurse practitioners, and physician assistants practicing in eye care.
There are no special prescription requirements, refill limitations, or prescriber DEA registration requirements associated with Rocklatan. Patients can receive up to 12 months of prescriptions at a time, and refills can be filled at any pharmacy without the controlled substance restrictions that apply to Schedule II–V medications.
Based on MERCURY 1 and MERCURY 2 clinical trial data, the most frequent side effects include:
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Latanoprost (generic / Xalatan)
Prostaglandin analog; one of Rocklatan's two components; widely available generic costing ~$10–$30/month. Good choice when only one mechanism is needed or as a cost-saving alternative.
Rhopressa (netarsudil 0.02%)
ROCK inhibitor alone; the other component of Rocklatan. Brand-only with similar pricing. Useful when latanoprost is not tolerated or when only the ROCK inhibitor mechanism is needed.
Vyzulta (latanoprostene bunod)
Next-generation prostaglandin with nitric oxide donation — dual mechanism in one ingredient. Once-daily, similar profile to Rocklatan but typically 1–3 mmHg less IOP lowering. No generic available.
Lumigan (bimatoprost)
Strong prostaglandin analog; generic bimatoprost available. Once-daily. Highly effective monotherapy; generic availability makes it much more affordable than Rocklatan.
Combigan (brimonidine/timolol)
Combination of alpha-2 agonist and beta-blocker; twice-daily; generic available. Works via different mechanisms than Rocklatan; useful when prostaglandins are contraindicated or not tolerated.
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Other prostaglandin analogs (Lumigan, Travatan Z, Vyzulta)
moderateCombining Rocklatan with another prostaglandin analog is not recommended — adding a second prostaglandin does not produce additional IOP lowering (receptor saturation) and may worsen side effects.
Other topical ophthalmic medications
minorWhen used concurrently with any other eye drops, administer at least 5 minutes apart to prevent dilution and ensure optimal absorption of all medications.
Corticosteroids (topical, inhaled, oral, or injected)
moderateCorticosteroids can raise intraocular pressure in steroid-responsive patients, potentially counteracting Rocklatan's IOP-lowering effect. Monitor IOP closely when corticosteroids are initiated or discontinued.
Soft contact lenses (benzalkonium chloride absorption)
minorRocklatan contains benzalkonium chloride (BAK), which is absorbed by soft contact lenses. Remove soft contacts before using Rocklatan and wait 15 minutes before reinserting.
NSAIDs (ibuprofen, naproxen, aspirin)
minorTheoretical interaction: systemic NSAIDs inhibit prostaglandin synthesis and may theoretically reduce latanoprost efficacy. Clinical significance is uncertain. Monitor IOP in patients who regularly use oral NSAIDs.
Rocklatan is one of the most powerful tools available for managing open-angle glaucoma and ocular hypertension. Its four-mechanism approach — combining a first-in-class ROCK inhibitor with the world's most prescribed prostaglandin — provides IOP lowering that exceeds what either component can achieve alone. For patients who haven't reached their target pressure on a single agent, Rocklatan offers a clinically proven step up.
The main challenges are practical: Rocklatan's high retail price ($450–$482 without insurance or discounts), its brand-only status with no generic until approximately 2034, and the inconsistent stocking at some pharmacies. These are real barriers — but they're manageable with the right tools and savings programs.
If you're having trouble finding Rocklatan at a pharmacy near you, medfinder can help. We contact pharmacies in your area to find which ones can fill your prescription — and text you the results.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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