Comprehensive medication guide to Pred-G including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$15–$60 copay for brand-name Pred-G on commercial insurance; typically placed on Tier 2–3 on most formularies. Medicare Part D generally covers it; prior authorization may be required on some plans if a generic alternative is preferred.
Estimated Cash Pricing
$185–$190 retail for brand-name 5 mL suspension without insurance; approximately $161–$172 with a GoodRx or SingleCare coupon at participating pharmacies for a typical course.
Medfinder Findability Score
62/100
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Pred-G is a brand-name prescription ophthalmic medication manufactured by Allergan (an AbbVie company). It combines two active ingredients — gentamicin sulfate 0.3% and prednisolone acetate 1% — in a single formulation designed to simultaneously treat bacterial eye infections and reduce ocular inflammation. It is available as an eye drop suspension (5 mL bottle) and as an ointment under the name Pred-G S.O.P. (3.5 g tube).
Pred-G is FDA-approved for steroid-responsive inflammatory ocular conditions where superficial bacterial infection or a risk of bacterial infection exists. Common indications include post-surgical eye care (particularly after cataract surgery), uveitis, chemical and radiation eye burns, bacterial conjunctivitis with inflammatory component, and blepharokeratoconjunctivitis.
Pred-G is not a controlled substance and does not require DEA registration to prescribe. It is a prescription-only medication not approved for use in patients under 18 years of age.
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Pred-G works through two complementary mechanisms — one to fight infection, one to control inflammation. Gentamicin is an aminoglycoside antibiotic that enters bacterial cells and binds to the 30S ribosomal subunit, causing misreading of the bacteria's genetic code. This leads to production of abnormal, non-functional proteins and ultimately bacterial cell death. Gentamicin is effective against a range of Gram-positive and Gram-negative organisms including Staphylococcus aureus, Pseudomonas aeruginosa, E. coli, H. influenzae, and Serratia marcescens.
Prednisolone acetate 1% is a potent corticosteroid that inhibits phospholipase A2, blocking the production of prostaglandins and leukotrienes that drive redness, swelling, and pain. It also reverses capillary permeability (reducing fluid leakage and tissue edema) and suppresses inflammatory immune cell activity. The 1% acetate concentration is a full-strength ophthalmic corticosteroid — the same potency as Pred Forte — appropriate for significant anterior segment inflammation.
Because Pred-G is applied directly to the eye (topical ophthalmic route), systemic absorption is minimal and drug interactions with other medications taken by mouth are generally not clinically significant. The medication works locally within the eye and surrounding tissues.
0.3%/1% (gentamicin 0.3% / prednisolone acetate 1%) — ophthalmic suspension (eye drops)
5 mL bottle. Instill 1 drop into affected eye(s) 2-4 times daily; up to 1 drop every hour during first 24-48 hours if needed. Maximum 20 mL without re-evaluation.
0.3%/0.6% (gentamicin 0.3% / prednisolone acetate 0.6%) — ophthalmic ointment (S.O.P.)
3.5 g tube. Apply 1/2 inch ribbon to conjunctival sac of affected eye(s) 1-3 times daily. Maximum 8 g without re-evaluation.
Pred-G is not listed on the FDA drug shortage database as of 2026, but it is genuinely difficult to find at many retail pharmacies. As a brand-name-only ophthalmic with no widely distributed generic equivalent and a single manufacturer (Allergan/AbbVie), Pred-G has a limited supply pool compared to medications with robust generic markets. Large retail chains often don't stock it in routine inventory, and when they do, it may not be on the shelf at any given location.
Independent pharmacies, hospital-affiliated pharmacies, and pharmacies near ophthalmology surgery centers are most likely to stock Pred-G consistently. Many pharmacies can also place special orders through their wholesale distributor, with typical 1–3 day turnaround.
The fastest way to locate Pred-G near you is to use medfinder, which contacts pharmacies in your area on your behalf to find which ones can fill your specific prescription.
Pred-G is not a controlled substance, so any licensed prescriber with prescriptive authority can write a prescription for it. There are no DEA registration or special prescribing requirements beyond standard prescriptive authority. The following providers commonly prescribe Pred-G:
Telehealth access for Pred-G is limited — most conditions requiring it need a slit-lamp examination that cannot be performed remotely. Some established patients may receive refill authorizations via telehealth, but new prescriptions for complex eye conditions typically require an in-person examination.
No. Pred-G (gentamicin/prednisolone ophthalmic) is not a DEA-scheduled controlled substance. It contains an aminoglycoside antibiotic (gentamicin) and a corticosteroid (prednisolone acetate) — neither of which is classified as a controlled substance under the U.S. Controlled Substances Act.
Because Pred-G is not a controlled substance, there are no DEA-specific restrictions on who can prescribe it, how many refills can be written, or how it must be dispensed. Any licensed prescriber with prescriptive authority — including physicians (MD/DO), optometrists (OD), nurse practitioners, and physician assistants — can prescribe Pred-G within their scope of practice. It remains a prescription-only medication and cannot be obtained without a valid prescription.
Common, usually mild and temporary side effects include:
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Tobradex (tobramycin/dexamethasone)
Most widely stocked antibiotic-steroid combination ophthalmic. Uses tobramycin (aminoglycoside) with dexamethasone 0.1% instead of prednisolone 1%. Generic available for $28–$55 with a coupon.
Maxitrol (neomycin/polymyxin B/dexamethasone)
Triple antibiotic plus steroid combination. Broader bacterial coverage but higher neomycin allergy risk. Generic costs $15–$40 — most affordable option.
Zylet (tobramycin/loteprednol)
Uses loteprednol, a 'soft' corticosteroid with lower risk of IOP elevation. Preferred for glaucoma-risk patients. Brand-only with limited generic availability.
Blephamide (sulfacetamide/prednisolone acetate 0.2%)
Contains prednisolone (same steroid as Pred-G) but at 0.2% — lower concentration. Uses sulfa antibiotic instead of gentamicin. Avoid if sulfa allergy.
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Other topical ophthalmic medications
minorWait at least 5 minutes between Pred-G and other eye drops to prevent dilution of either medication. Apply eye drops before ointments (if using both) and wait at least 10 minutes.
Glaucoma eye drops (timolol, latanoprost, brimonidine, etc.)
moderatePrednisolone in Pred-G can counteract the IOP-lowering effect of glaucoma medications. Patients on glaucoma therapy require close intraocular pressure monitoring when Pred-G is added.
Systemic corticosteroids (oral prednisone, inhaled steroids)
moderateCombined steroid load may increase the risk of elevated intraocular pressure. Enhanced monitoring of IOP is warranted when Pred-G is used alongside systemic corticosteroids.
Antifungal agents
majorThe steroid component of Pred-G can suppress immune defense against fungi. If a secondary fungal infection develops during Pred-G use, antifungal therapy and possible discontinuation of Pred-G are required.
Antiviral medications for herpes simplex
majorPred-G is contraindicated with herpes simplex keratitis. The corticosteroid can cause the virus to spread more aggressively. If herpes keratitis is suspected, Pred-G must be discontinued immediately.
Pred-G remains a clinically valuable combination ophthalmic for conditions where both bacterial infection control and significant anti-inflammatory therapy are needed simultaneously. The full-strength prednisolone acetate 1% component sets it apart from some alternatives and makes it particularly relevant for post-cataract surgery care and anterior segment inflammation. Its primary limitations are cost (brand-only, no widely available generic) and availability (routinely under-stocked at chain pharmacies).
For patients prescribed Pred-G, the most important steps are: confirming pharmacy availability before your fill date, understanding your insurance coverage and available savings options, attending all follow-up eye exams for intraocular pressure monitoring, and knowing which clinical alternatives your provider can prescribe if Pred-G remains unavailable.
If you're having trouble filling your Pred-G prescription, medfinder can help you locate a pharmacy near you that has it in stock — without the time-consuming process of calling each pharmacy yourself.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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