Comprehensive medication guide to MicRhoGAM including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$50 copay when administered in a clinical setting; covered as preventive obstetric care under most private insurance, Medicaid, and Medicare Part B. No pharmacy deductible typically applies when billed as a medical benefit.
Estimated Cash Pricing
$100–$300+ per dose at retail pharmacies; most patients receive MicRhoGAM in a clinical setting where it is billed as a medical benefit, often with little or no out-of-pocket cost with insurance.
Medfinder Findability Score
45/100
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MicRhoGAM (Rho(D) immune globulin human, mini-dose) is a biological medication made from human blood plasma. It contains concentrated IgG antibodies against the Rh(D) antigen — a protein found on the red blood cells of Rh-positive individuals. MicRhoGAM is the mini-dose formulation containing 50 mcg (250 IU), designed specifically for early pregnancy events at or before 12 weeks of gestation.
MicRhoGAM is manufactured by Kedrion Biopharma Inc. and has been FDA-approved since 1968 (BLA 103777). It is an intramuscular injection administered by a healthcare professional as a single prefilled syringe. It is not a controlled substance and can be prescribed by any licensed healthcare provider.
MicRhoGAM is FDA-approved for Rh-negative, non-sensitized patients following spontaneous abortion, induced abortion, ectopic pregnancy, or threatened abortion occurring at or before 12 weeks of gestation, and for transfusion of less than 2.5 mL of Rh-positive red blood cells.
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MicRhoGAM works through antibody-mediated immune suppression. When a Rh-negative individual experiences a first-trimester pregnancy event, small amounts of fetal Rh-positive blood cells may enter the mother's circulation. Without intervention, the mother's immune system may recognize these foreign Rh(D)-positive cells and develop lasting anti-D antibodies — a process called Rh sensitization or Rh isoimmunization.
MicRhoGAM delivers pre-made anti-D IgG antibodies derived from human plasma donors. These antibodies coat and trigger rapid clearance of any circulating Rh-positive fetal red blood cells before the mother's own immune system has time to form a lasting memory response. By eliminating the foreign antigen before the immune machinery can respond, MicRhoGAM prevents Rh sensitization entirely.
The 50 mcg (250 IU) mini-dose is sufficient to suppress the immune response to 2.5 mL or less of Rh-positive red blood cells — the typical volume involved in first-trimester events. Administration must occur within 72 hours of the at-risk event for maximum effectiveness. Clinical studies demonstrated 100% efficacy when given within 3 hours after first-trimester termination.
50 mcg (250 IU) — prefilled syringe, intramuscular injection
Single-dose prefilled syringe for first-trimester obstetric events at or before 12 weeks gestation
MicRhoGAM has been affected by a significant Rho(D) immune globulin shortage that began in December 2023 and was formally announced by the FDA, ASHP, and AABB in March 2024. The shortage was caused by anti-D plasma supply constraints and manufacturing deviations at Kedrion Biopharma, the sole U.S. manufacturer of MicRhoGAM.
Retail pharmacies have been hardest hit. Hospitals, OB clinics, and infusion centers often have more reliable supply through institutional purchasing channels. Equivalent products — HyperRHO S/D Mini-Dose (Grifols) and full-dose alternatives from CSL Behring and Kamada — have been more available during the shortage. Availability is improving in 2026 but remains uneven across regions.
To find MicRhoGAM or an equivalent in stock near you, medfinder calls pharmacies in your area and texts you which ones can fill your prescription — saving you from calling pharmacies one by one during an urgent 72-hour window.
MicRhoGAM is not a controlled substance and has no DEA scheduling requirements. Any licensed prescriber with a standard medical license can prescribe it, making access straightforward compared to controlled medications. A prescription is required, but no special waivers or certifications are needed.
Healthcare providers who commonly prescribe MicRhoGAM include:
Obstetrician-Gynecologists (OB/GYNs) — primary prescribers for obstetric RhIg
Certified Nurse Midwives (CNMs)
Family Medicine physicians
Emergency Medicine physicians
Nurse Practitioners (NPs) and Physician Assistants (PAs)
Reproductive health clinic providers (Planned Parenthood, etc.)
Telehealth providers can prescribe MicRhoGAM remotely since it is not a controlled substance; however, the injection must still be administered in person by a healthcare professional. Telehealth OB/GYN services can help patients obtain prescriptions quickly and direct them to a nearby clinical site for administration.
No. MicRhoGAM (Rho(D) immune globulin) is not a controlled substance and has no DEA scheduling. Any licensed prescriber — including OB/GYNs, certified nurse midwives, family medicine physicians, emergency physicians, nurse practitioners, and physician assistants — can prescribe MicRhoGAM without any special DEA registration or controlled substance waiver.
Although MicRhoGAM is not a controlled substance, it does require a prescription — it cannot be purchased over the counter. It is a biologic made from human plasma and must be administered by a healthcare professional as an intramuscular injection. It cannot be dispensed for self-administration at home.
MicRhoGAM is generally well tolerated. Common side effects include:
Injection site reactions: swelling, redness, pain, warmth, or induration
Mild, low-grade fever
Body aches or mild malaise
Mild skin rash (rare)
Serious side effects are extremely rare, but patients should seek immediate emergency care if they experience:
Anaphylaxis: hives, urticaria, chest tightness, wheezing, low blood pressure, or difficulty breathing
Hemolytic reaction (if inadvertently given to Rh-positive patient): fever, back pain, dark or red urine
Patients should be observed for at least 20 minutes after administration. There have been no reported fatalities due to anaphylaxis or any other cause related to MicRhoGAM administration.
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HyperRHO S/D Mini-Dose
Direct equivalent mini-dose (50 mcg/250 IU IM) by Grifols Therapeutics; clinically interchangeable with MicRhoGAM for first-trimester indications
RhoGAM Ultra-Filtered PLUS
Full-dose (300 mcg/1500 IU IM) by Kedrion Biopharma; same manufacturer as MicRhoGAM; acceptable substitution when mini-dose unavailable
Rhophylac
Full-dose (300 mcg/1500 IU IM or IV) by CSL Behring; can be given IM or IV; useful option during MicRhoGAM shortage
WinRho SDF
Multiple strengths (IM or IV) by Kamada Ltd; also indicated for ITP; shortage resolved August 2024
Prefer MicRhoGAM? We can find it.
Live vaccines (MMR, varicella, zoster)
moderateMicRhoGAM may impair efficacy of live vaccines. Delay live vaccines at least 12 weeks after MicRhoGAM. Wait at least 3 weeks after live vaccination before giving MicRhoGAM unless clinically urgent.
Axicabtagene ciloleucel (Yescarta)
majorImmunosuppressive effects increase risk of infection. Avoid concurrent use.
Brexucabtagene autoleucel (Tecartus)
majorImmunosuppressive effects increase risk of infection. Avoid concurrent use.
Ciltacabtagene autoleucel (Carvykti)
majorImmunosuppressive effects increase risk of infection. Avoid concurrent use.
Idecabtagene vicleucel (Abecma)
majorImmunosuppressive effects increase risk of infection. Avoid concurrent use.
MicRhoGAM is one of the most important preventive biologics in obstetric medicine, with over 50 years of proven efficacy in preventing Rh sensitization. For Rh-negative patients who experience a first-trimester pregnancy loss, receiving it within 72 hours is critical — not just for the current event, but to protect all future pregnancies.
The ongoing supply disruption since 2023 has made locating MicRhoGAM more challenging, but equivalent alternatives (HyperRHO S/D Mini-Dose) and full-dose substitutions mean that Rh-negative patients should not go without protection. If your regular pharmacy doesn't have it, contact your provider immediately and explore alternatives.
If you're struggling to find MicRhoGAM in stock near you, medfinder contacts pharmacies on your behalf and texts you which ones can fill your prescription — so you can focus on your health instead of spending hours on hold.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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