Comprehensive medication guide to Invokamet including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$50–$150 copay as non-preferred brand; prior authorization or step therapy often required.
Estimated Cash Pricing
$575–$800/month retail; eligible commercially insured patients may pay $0 via Janssen CarePath Savings Program.
Medfinder Findability Score
55/100
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Invokamet is a prescription combination medication containing Canagliflozin (an SGLT2 inhibitor) and Metformin Hydrochloride (a biguanide). It is used alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes when treatment with both Canagliflozin and Metformin is appropriate.
The Canagliflozin component has also been shown to reduce the risk of major adverse cardiovascular events — including heart attack, stroke, and cardiovascular death — in adults with type 2 diabetes and established cardiovascular disease.
Invokamet is manufactured by Janssen Pharmaceuticals (a Johnson & Johnson company) and is available in both immediate-release (Invokamet) and extended-release (Invokamet XR) formulations.
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Invokamet combines two complementary mechanisms to lower blood sugar:
By targeting multiple pathways, Invokamet provides more comprehensive blood sugar control than either medication alone.
Canagliflozin 50 mg / Metformin 500 mg
Canagliflozin 50 mg / Metformin 1000 mg
Canagliflozin 150 mg / Metformin 500 mg
Canagliflozin 150 mg / Metformin 1000 mg
Canagliflozin 50 mg / Metformin 500 mg
Canagliflozin 50 mg / Metformin 1000 mg
Canagliflozin 150 mg / Metformin 500 mg
Canagliflozin 150 mg / Metformin 1000 mg
Invokamet scores a 55 out of 100 on our findability scale. As a brand-name combination product with no generic available, Invokamet can be harder to find than common generics. It is not currently on the FDA Drug Shortage list, but availability varies by pharmacy and specific strengths may be intermittently out of stock. Not every pharmacy stocks this niche combination product, so you may need to call around or use Medfinder to locate it near you.
Invokamet can be prescribed by a range of healthcare providers, including:
Telehealth consultations are also available for Invokamet prescriptions. If you're having trouble finding a prescriber, Medfinder can help you locate one.
No. Invokamet is not a controlled substance and has no DEA scheduling. It does not carry a risk of abuse or dependence. Invokamet can be prescribed with refills and does not require special prescribing procedures like triplicate prescriptions.
Serious side effects (seek immediate medical attention):
Contact your healthcare provider if you experience any concerning symptoms.
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Synjardy / Synjardy XR (Empagliflozin/Metformin):
A similar SGLT2 inhibitor + Metformin combination with proven cardiovascular and renal benefits. No boxed warning for amputation risk.
Xigduo XR (Dapagliflozin/Metformin Extended-Release):
Once-daily SGLT2 inhibitor + Metformin combination. Dapagliflozin also has heart failure and chronic kidney disease indications.
Segluromet (Ertugliflozin/Metformin):
Another SGLT2 inhibitor + Metformin combination, though Ertugliflozin has less cardiovascular outcome data.
Invokana + Generic Metformin (separate pills):
Same active ingredients taken as individual tablets. Generic Metformin costs $4–$20/month, allowing more flexible dosing.
Prefer Invokamet? We can find it.
Insulin and Sulfonylureas:
moderateIncreased risk of hypoglycemia; dose reduction may be needed
UGT Enzyme Inducers (Rifampin, Phenytoin, Phenobarbital, Ritonavir):
moderateMay decrease Canagliflozin levels; dose adjustment may be required
Carbonic Anhydrase Inhibitors (Topiramate, Zonisamide, Acetazolamide):
moderateIncreased risk of lactic acidosis
Digoxin:
moderateCanagliflozin increases Digoxin exposure; monitor levels closely
Diuretics:
moderateAdditive dehydration and low blood pressure risk
ACE Inhibitors and ARBs:
moderateAdditive blood pressure lowering and kidney effects
Alcohol:
moderateSignificantly increases the risk of lactic acidosis — avoid excessive intake
Invokamet is an effective combination medication for managing type 2 diabetes, offering the dual benefits of an SGLT2 inhibitor and Metformin in a single tablet. With no generic available, the cash price of $575–$800/month can be a barrier — but the Janssen CarePath Savings Program may bring the cost to $0 for eligible commercially insured patients, and the Johnson & Johnson Patient Assistance Foundation provides free medication for qualifying uninsured patients.
Because Invokamet is a brand-name niche product, not every pharmacy keeps it in stock. If you're having trouble finding Invokamet, use Medfinder to locate pharmacies near you that have it available. You can also ask your doctor about alternatives like Synjardy or Xigduo XR, or about taking Invokana and generic Metformin as separate pills.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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