Comprehensive medication guide to Dantrolene including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$10–$50/month
Estimated Cash Pricing
$50–$200/month
Medfinder Findability Score
60/100
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Dantrolene is a direct-acting skeletal muscle relaxant used to treat chronic muscle spasticity associated with conditions such as multiple sclerosis, cerebral palsy, spinal cord injuries, and stroke. Unlike other muscle relaxants that work in the brain or spinal cord, Dantrolene acts directly on the muscle fibers themselves. It is also the only FDA-approved treatment for malignant hyperthermia, a rare but life-threatening reaction to certain anesthesia drugs. Dantrolene is available as a generic medication and under brand names including Dantrium, Revonto, and Ryanodex.
25 mg capsules
typically the starting dose
50 mg capsules
common maintenance dose
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100 mg capsules
higher-dose option for patients who need it
Injectable forms
Dantrium IV (20 mg vials), Ryanodex (250 mg suspension), and Revonto (20 mg vials) are used in hospital settings for malignant hyperthermia emergencies
⚠️ Black Box Warning: Dantrolene carries an FDA black box warning for hepatotoxicity (liver damage). The risk is highest at doses above 200 mg per day and with use exceeding 60 days. Liver function tests should be monitored regularly.
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Baclofen
a centrally-acting muscle relaxant commonly used for spasticity from spinal cord injuries and multiple sclerosis
Tizanidine (Zanaflex)
another centrally-acting option that works on alpha-2 receptors to reduce muscle tone
Botox injections (onabotulinumtoxinA)
targeted injections that can relax specific muscle groups for several months at a time
Diazepam (Valium)
a benzodiazepine sometimes used for muscle spasms, though it carries sedation and dependence risks
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Calcium channel blockers (e.g., verapamil)
moderatecan cause dangerous drops in blood pressure and heart rhythm changes when combined with IV dantrolene
CNS depressants (benzodiazepines, opioids, alcohol)
moderatemay increase sedation and drowsiness
Hepatotoxic drugs (e.g., acetaminophen at high doses, statins)
moderatemay increase the risk of liver damage
Estrogen-containing medications
moderatemay increase the risk of liver toxicity, especially in women over 35
Warfarin and other blood thinners
moderateDantrolene may alter protein binding; monitoring may be needed
Metoclopramide
moderatemay decrease absorption of Dantrolene
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