Comprehensive medication guide to Blujepa including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$30–$75 copay with commercial insurance; prior authorization and step therapy (trying Nitrofurantoin or Bactrim first) often required.
Estimated Cash Pricing
$400–$600 for a 5-day course (10 tablets); no generic available yet, so coupon discounts are limited.
Medfinder Findability Score
60/100
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Blujepa (Gepotidacin) is a first-in-class triazaacenaphthylene antibiotic manufactured by GSK. It was approved by the FDA in March 2025 for treating uncomplicated urinary tract infections (uUTIs) in female patients aged 12 and older (weighing at least 40 kg). In December 2025, it also received approval for uncomplicated urogenital gonorrhea in patients with limited or no alternative treatment options. Blujepa represents an entirely new class of antibiotics, offering an important option for patients dealing with antibiotic-resistant infections.
Blujepa works by inhibiting bacterial DNA replication through a novel mechanism. It targets two essential bacterial enzymes — (topoisomerase II) and — by binding to a unique site on these enzymes that is distinct from where fluoroquinolones bind. This means Blujepa can be effective even against bacteria that have developed resistance to fluoroquinolone antibiotics like Ciprofloxacin or Levofloxacin. By blocking these enzymes, Blujepa prevents bacteria from replicating their DNA, ultimately killing the infection.
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750 mg film-coated tablets
the only available formulation
Blujepa (Gepotidacin) is a first-in-class antibiotic approved in March 2025, making it relatively new to the market. Because it is brand-only and manufactured solely by GSK, many pharmacies do not routinely stock it. While there is no active FDA shortage, patients may need to call multiple pharmacies or request a special order. Specialty pharmacies and larger chain pharmacies in urban areas are more likely to have it on hand. Medfinder can help you locate pharmacies with Blujepa in stock near you.
Blujepa can be prescribed by a wide range of healthcare providers, including:
Telehealth consultations can also result in a Blujepa prescription for eligible patients with straightforward UTI or gonorrhea cases.
No, Blujepa is not a controlled substance. It is a prescription-only (Rx) antibiotic with no DEA scheduling. You will need a valid prescription from a licensed healthcare provider, but there are no special controlled substance restrictions on refills or dispensing.
Taking Blujepa after a meal can help reduce gastrointestinal side effects. Serious but rare side effects include QTc prolongation (irregular heartbeat), Clostridioides difficile-associated diarrhea, severe allergic reactions, and seizures. Contact your doctor immediately if you experience chest palpitations, severe or persistent diarrhea, or signs of an allergic reaction.
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Nitrofurantoin (Macrobid)
a standard first-line treatment for uncomplicated UTIs, widely available as a generic
Trimethoprim-Sulfamethoxazole (Bactrim)
another commonly prescribed UTI antibiotic, available as a low-cost generic
Fosfomycin (Monurol)
a single-dose UTI treatment option
Ceftriaxone
the standard injectable treatment for gonorrhea
Prefer Blujepa? We can find it.
Strong CYP3A4 inhibitors
moderate(Ketoconazole, Itraconazole, Clarithromycin, Ritonavir) — avoid concomitant use due to increased Blujepa exposure and QTc prolongation risk
Strong CYP3A4 inducers
moderate(Rifampin, Carbamazepine, Phenytoin) — may reduce Blujepa's effectiveness
QTc-prolonging drugs
moderate(certain antiarrhythmics, antipsychotics, Fluoroquinolones) — avoid concomitant use
Digoxin
moderateBlujepa may increase Digoxin levels; monitor closely
Midazolam
moderateBlujepa may increase Midazolam exposure
Grapefruit and grapefruit juice
moderatemay increase Blujepa levels
St. John's Wort
moderatemay decrease Blujepa effectiveness
Blujepa is a groundbreaking first-in-class antibiotic that offers a new treatment pathway for uncomplicated UTIs and gonorrhea — especially important as antibiotic resistance continues to grow. As a brand-name only medication from GSK, it can be expensive without insurance and may not be stocked at every pharmacy. If your doctor has prescribed Blujepa, use Medfinder to quickly locate pharmacies near you that have it in stock. Check with GSK's copay savings programs or the GSK For You patient assistance program (gskforyou.com or 1-888-825-5249) if cost is a concern.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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