What Is Wixela Inhub? Uses, Dosage, and What You Need to Know in 2026

What Is Wixela Inhub?

Wixela Inhub is a prescription combination inhaler containing two active medications: fluticasone propionate (an inhaled corticosteroid, or ICS) and salmeterol (a long-acting beta agonist, or LABA). It is manufactured by Viatris (formerly Mylan) and was FDA-approved in January 2019 as the first generic version of Advair Diskus — one of the most prescribed inhalers in the United States.

Like Advair Diskus, Wixela Inhub comes as a dry powder inhaler (DPI). It uses its own proprietary device called the "Inhub" — distinct from the Diskus device used with brand-name Advair, though both deliver the same medication.

What Is Wixela Inhub Used For?

Wixela Inhub has two FDA-approved indications:

• Asthma maintenance: Approved for patients age 4 and older with persistent asthma that is not adequately controlled with an ICS alone, or for patients whose disease severity warrants treatment with both an ICS and a LABA from the start.
• COPD maintenance: Approved for maintenance treatment of airflow obstruction in adults with COPD (chronic bronchitis and emphysema) and to reduce COPD exacerbations in patients with a history of exacerbations.

Important: Wixela Inhub is a maintenance (controller) medication — it is NOT a rescue inhaler. It will not treat a sudden asthma attack or acute COPD exacerbation. Always keep a separate short-acting rescue inhaler (such as albuterol) on hand.

What Strengths Does Wixela Inhub Come In?

Wixela Inhub is available in three strengths (fluticasone propionate/salmeterol):

• 100/50 mcg: Low-dose ICS. Approved for asthma only. Common starting dose for patients with mild-to-moderate persistent asthma.
• 250/50 mcg: Medium-dose ICS. Approved for both asthma and COPD. The only strength approved for COPD.
• 500/50 mcg: High-dose ICS. Approved for asthma only. Used for patients with severe or uncontrolled asthma.

How Do You Use Wixela Inhub?

The standard dose for both asthma and COPD is one inhalation twice daily, approximately 12 hours apart. Each Wixela Inhub inhaler contains 60 doses — a 30-day supply.

Important use instructions:

1. Hold the Inhub device in a vertical position (upright)
2. Slide the cover down to open the inhaler and load a dose
3. Breathe out fully (away from the inhaler)
4. Place the mouthpiece between your lips and inhale deeply and steadily
5. Hold your breath for 3–4 seconds, then breathe out slowly
6. Rinse your mouth with water and spit it out — do not swallow. This prevents thrush.

Storage and Handling

Store Wixela Inhub at room temperature (68–77°F). Keep unused inhalers in their original foil pouch. Once you open the foil pouch, write the "use by" date on the label — you have exactly 30 days to use it, even if doses remain. Discard after 30 days or when the dose counter reads "0," whichever comes first.

Who Should NOT Use Wixela Inhub?

Wixela Inhub is contraindicated for:

• Primary treatment of acute asthma attacks or COPD exacerbations (use rescue inhaler instead)
• Patients with severe hypersensitivity to milk proteins (the inhaler contains lactose from cow's milk)
• Patients with known hypersensitivity to fluticasone propionate, salmeterol, or any excipients

How Much Does Wixela Inhub Cost in 2026?

Without insurance, Wixela Inhub costs $100–$230 per inhaler depending on strength and pharmacy. With insurance (Tier 2 generic), most patients pay $0–$50. Commercially insured patients can use the Viatris Savings Card to pay as little as $10/month. For a full breakdown of savings options, see: How to Save Money on Wixela Inhub in 2026.