What Is Peridex? Uses, Dosage, and What You Need to Know in 2026

If your dentist prescribed Peridex, you probably have questions. What is it? How does it work? How long do you need to take it? This guide answers all of these questions so you know exactly what to expect when you use Peridex.

What Is Peridex?

Peridex is the brand name for chlorhexidine gluconate 0.12% oral rinse—a prescription-strength antiseptic mouthwash. The FDA first approved it in August 1986. It is used to treat gingivitis, a form of gum disease characterized by redness, swelling, and bleeding of the gums. Other brand names for the same drug include PerioGard and Paroex; the generic version is widely available.

What Does Peridex Treat?

Peridex is FDA-approved for the treatment of gingivitis as part of a professional dental program. Your dentist will typically prescribe it alongside a professional cleaning, and you will use it at home in combination with regular brushing and flossing.

Off-label, dental providers may also use chlorhexidine rinse for:

Post-surgical oral care (after tooth extractions, implant placement, or periodontal surgery)

Prevention of oral mucositis in patients undergoing chemotherapy

Pre-procedural oral rinse to reduce bacterial load before dental procedures

What Does Peridex Look and Taste Like?

Peridex is a near-neutral solution (pH 5–7) that is colorless to pale yellow in appearance (some formulations are light blue). It contains 11.6% alcohol as well as glycerin and flavoring. The taste is distinctly bitter—this is normal and expected. Many patients notice that food tastes slightly different for a few hours after rinsing, which is also a known side effect.

How to Use Peridex Correctly

Using Peridex correctly is important for both effectiveness and minimizing side effects:

Brush and floss your teeth thoroughly first. Rinse out all toothpaste from your mouth.

Measure 15 mL (one capful—the cap itself is a measuring cup) of undiluted Peridex. Do not dilute with water.

Swish the rinse around your entire mouth for 30 seconds. Try to swish it to all areas of your mouth—between teeth, along the gumline, under your tongue.

Spit it out completely. Do not swallow Peridex.

Do not rinse with water, eat, drink, or brush your teeth immediately afterward. Wait at least 30 minutes before eating or drinking to allow the medication to remain active on your gum tissue.

Use twice daily—morning and evening after brushing. Follow this routine for the duration prescribed by your dentist (typically 2–6 months).

What Is the Standard Dosage?

The FDA-approved dosage is:

Amount per use: 15 mL (1 tablespoon / 1 capful) of undiluted rinse

Frequency: Twice daily (morning and evening)

Duration: As prescribed by your dentist, typically up to 6 months

When: After brushing and flossing, after meals

Is Peridex Safe?

Yes, when used as directed. Peridex is not significantly absorbed through the gut when used as a mouthwash—studies show it is poorly absorbed from the gastrointestinal tract. About 30% of the active ingredient is retained in the oral cavity after rinsing, which is then slowly released over time. Less than 1% of the drug ends up in the urine; about 90% is excreted in feces. It should not be swallowed.

Peridex is not approved for children under 18. If you are pregnant, use it only if clearly directed by your healthcare provider (it is Pregnancy Category B). Safety during breastfeeding has not been established.

Is Peridex a Controlled Substance?

No. Peridex (chlorhexidine gluconate) is not a controlled substance and has no DEA schedule. It is a prescription-only medication, but it has no abuse potential and no special prescribing restrictions. Your dentist does not need a DEA number to prescribe it.

Where to Fill Your Peridex Prescription

Peridex and its generic are available at most major pharmacy chains. If you are having trouble locating it, medfinder can find a pharmacy with it in stock near you. For tips on reducing cost, see our guide on how to save money on Peridex in 2026.