What Is Myfembree? Uses, Dosage, and What You Need to Know in 2026

Myfembree Is a Once-Daily Oral Medication That Treats Heavy Menstrual Bleeding From Uterine Fibroids and Moderate to Severe Endometriosis Pain in Premenopausal Women

If your doctor has mentioned Myfembree — or you've been researching treatment options for fibroids or endometriosis — you probably have questions. What exactly is it? How do you take it? What does it cost? This guide covers everything you need to know about Myfembree in 2026.

What Is Myfembree?

Myfembree is a brand-name prescription medication that combines three active ingredients in a single tablet:

• Relugolix (40 mg) — a GnRH receptor antagonist
• Estradiol (1 mg) — an estrogen
• Norethindrone Acetate (0.5 mg) — a progestin

The generic name is Relugolix/Estradiol/Norethindrone Acetate. A generic version is now available.

Myfembree is manufactured by Myovant Sciences (a subsidiary of Sumitovant Biopharma/Sumitomo Pharma) in collaboration with Pfizer. It belongs to the drug class known as GnRH receptor antagonist combinations with hormonal add-back therapy.

Myfembree is not a controlled substance and does not have a DEA schedule.

What Is Myfembree Used For?

Myfembree is FDA-approved for two indications:

1. Management of heavy menstrual bleeding associated with uterine fibroids in premenopausal women
2. Management of moderate to severe pain associated with endometriosis in premenopausal women

Uterine Fibroids

Uterine fibroids are noncancerous growths in the uterus that can cause heavy, prolonged periods, pelvic pain, and other symptoms. Myfembree works by reducing estrogen levels, which can shrink fibroids and significantly reduce menstrual bleeding.

Endometriosis

Endometriosis occurs when tissue similar to the uterine lining grows outside the uterus, causing chronic pain, especially during periods. Myfembree helps manage this pain by suppressing the hormonal cycle that drives endometriosis growth.

For a deeper explanation, see our article on how Myfembree works.

How Is Myfembree Taken?

Myfembree is taken as one tablet by mouth, once daily, with or without food. Here are the key details:

• Dosage: 40 mg Relugolix / 1 mg Estradiol / 0.5 mg Norethindrone Acetate
• Frequency: Once daily
• Duration: Treatment is limited to 24 months due to the risk of bone loss
• Pregnancy test: Required before starting treatment
• Contraception: Myfembree is not a contraceptive. Use non-hormonal birth control (like condoms or a copper IUD) while taking it

Special Instructions

If you take an oral P-gp inhibitor (such as Cyclosporine, Erythromycin, Ketoconazole, or Verapamil), take Myfembree first and wait at least 6 hours before taking the P-gp inhibitor. For more on drug interactions, see our guide on Myfembree drug interactions.

Who Should Not Take Myfembree?

Myfembree is contraindicated (should not be used) in women who:

• Are at high risk for blood clots, stroke, or heart attack
• Are pregnant or may become pregnant
• Have known osteoporosis
• Have or have had breast cancer or other hormone-sensitive cancers
• Have liver disease or hepatic impairment
• Have undiagnosed abnormal uterine bleeding
• Are allergic to any component of Myfembree

Myfembree is not for postmenopausal women. It is also not recommended during breastfeeding.

What Are the Side Effects?

Common side effects include headache, hot flashes, night sweats, nausea, hair thinning, fatigue, and menstrual changes. The most serious risk is thromboembolic events (blood clots, stroke, heart attack), which carries a boxed warning.

For a complete breakdown, read our detailed guide on Myfembree side effects.

How Much Does Myfembree Cost?

Myfembree is an expensive medication. Here's what you can expect to pay in 2026:

• Brand-name cash price: $1,200 to $1,700 per month (28-day supply)
• Generic cash price: Approximately $1,150 per month with discount coupons
• With insurance: Most commercial plans cover Myfembree but typically require prior authorization. Copays vary widely depending on your plan.
• Medicare Part D: Often covered with tiered copays. The 2025 Part D out-of-pocket cap of $2,000/year may help reduce annual costs.

Ways to Save

• Myfembree Copay Assistance Program: Commercially insured patients may pay as little as $0 per fill
• Myovant Patient Assistance Program: For uninsured or underinsured patients
• Discount coupons: SingleCare, GoodRx, and others offer savings on the generic version

See our full guide on how to save money on Myfembree for more options.

How Does Myfembree Compare to Alternatives?

Several other medications treat uterine fibroids and endometriosis:

• Oriahnn (Elagolix/Estradiol/Norethindrone Acetate) — Similar combination approach, but requires twice-daily dosing. Approved only for fibroids, not endometriosis.
• Orilissa (Elagolix) — Oral GnRH antagonist for endometriosis. No hormonal add-back included.
• Lupron Depot (Leuprolide Acetate) — Injectable GnRH agonist given monthly or every 3 months. Older therapy with more bone loss risk.

For a full comparison, see our article on alternatives to Myfembree.

Final Thoughts

Myfembree represents a significant advance in treating uterine fibroids and endometriosis — offering an oral, once-daily option that many women find more convenient than injections or surgery. If your doctor has prescribed Myfembree, or you're considering asking about it, this guide should give you a solid foundation.

Ready to fill your prescription? Use Medfinder to find Myfembree in stock near you.