Can't Find Myfembree? Here Are Your Alternatives

If you've been prescribed Myfembree for uterine fibroids or endometriosis and can't find it at your pharmacy, you're probably wondering: what are my other options? The good news is that there are several alternative medications that work in similar ways to Myfembree. While none are exact replacements, they may help manage your symptoms while you work on getting your Myfembree prescription filled.

Important: Never switch medications on your own. Always talk to your doctor before starting or stopping any treatment. This article is for informational purposes only.

What Is Myfembree and How Does It Work?

Myfembree is a once-daily oral tablet that combines three ingredients:

• Relugolix (40 mg) — a GnRH receptor antagonist that suppresses the hormones (LH and FSH) that stimulate estrogen production. By lowering estrogen levels, it helps shrink uterine fibroids and reduce endometriosis symptoms.
• Estradiol (1 mg) — a form of estrogen provided as "add-back" therapy to prevent the bone loss and severe hot flashes that come with GnRH suppression.
• Norethindrone Acetate (0.5 mg) — a progestin that works alongside estradiol to protect the uterine lining and support bone health.

Myfembree is FDA-approved for two conditions in premenopausal women:

1. Heavy menstrual bleeding caused by uterine fibroids
2. Moderate to severe pain associated with endometriosis

For a deeper dive into how this medication works, see our article on Myfembree's mechanism of action.

Alternative Medications to Myfembree

The following medications work through similar hormonal pathways and are used for the same or related conditions. Your doctor can help determine which one might be right for you based on your specific diagnosis, medical history, and insurance coverage.

1. Oriahnn (Elagolix/Estradiol/Norethindrone Acetate)

What it's for: Heavy menstrual bleeding caused by uterine fibroids (not approved for endometriosis)

How it works: Like Myfembree, Oriahnn contains a GnRH antagonist (Elagolix) combined with estrogen and progestin add-back therapy. It works by suppressing the hormones that drive fibroid growth while protecting bone health.

Key differences from Myfembree:

• Oriahnn requires twice-daily dosing (one morning capsule and one evening capsule), compared to Myfembree's once-daily tablet
• It's only FDA-approved for uterine fibroids, not endometriosis
• The GnRH antagonist component is Elagolix rather than Relugolix

Cost: Oriahnn is also a brand-name specialty medication with a similar price range to Myfembree. Check with your insurance for coverage details.

2. Orilissa (Elagolix)

What it's for: Moderate to severe endometriosis pain

How it works: Orilissa contains Elagolix alone — the same GnRH antagonist found in Oriahnn, but without estrogen and progestin add-back therapy. It reduces estrogen levels to help relieve endometriosis pain.

Key differences from Myfembree:

• Available in two doses: 150 mg once daily and 200 mg twice daily
• No add-back therapy included, which means higher risk of bone loss and hot flashes
• Treatment duration is more limited: up to 24 months for the 150 mg dose and 6 months for the 200 mg dose
• Only approved for endometriosis (not uterine fibroids)

Cost: Orilissa typically costs $900 to $1,100 per month without insurance, though discount programs may be available.

3. Lupron Depot (Leuprolide Acetate)

What it's for: Endometriosis, uterine fibroids, and other conditions

How it works: Unlike the GnRH antagonists above, Lupron Depot is a GnRH agonist. It initially stimulates hormone production before ultimately suppressing it (a phenomenon called "flare"). This eventually reduces estrogen levels, shrinking fibroids and reducing endometriosis symptoms.

Key differences from Myfembree:

• Given as an injection (monthly or every 3 months) rather than a daily pill
• Causes an initial hormone "flare" that can temporarily worsen symptoms
• Has been used for decades and is well-studied
• Often used short-term (3-6 months) due to bone loss risk, sometimes with separate add-back therapy prescribed alongside

Cost: Lupron Depot injections can cost $1,000 to $3,000+ per injection, depending on the dose and administration setting. Generic Leuprolide options may be less expensive.

How to Decide Which Alternative Is Right for You

The best alternative depends on several factors:

• Your diagnosis: If you have uterine fibroids, Oriahnn is the closest alternative. If you have endometriosis, Orilissa may be a better fit.
• Dosing preference: If once-daily dosing is important to you, note that Oriahnn and the higher dose of Orilissa both require twice-daily dosing.
• Route of administration: If you prefer pills over injections, Oriahnn and Orilissa are oral options. If injections are acceptable, Lupron Depot is an option.
• Bone health: If you're concerned about bone loss, medications with add-back therapy (Oriahnn) may be preferred over those without (Orilissa, Lupron alone).
• Insurance coverage and cost: Your insurance plan may cover one medication but not another. Check with your insurer and explore savings programs for each option.

Don't Give Up on Myfembree

If your doctor specifically prescribed Myfembree and you'd prefer to stay on it, don't give up. There are tools that can help you find it:

• Medfinder shows you real-time pharmacy availability near your ZIP code
• Specialty pharmacies are more likely to carry Myfembree than retail chains
• The manufacturer's Copay Assistance Program can help with both cost and pharmacy coordination

For step-by-step guidance, see our article on how to find Myfembree in stock near you.

Final Thoughts

Having trouble filling a Myfembree prescription is frustrating, especially when you're dealing with painful or heavy periods. The alternatives listed here — Oriahnn, Orilissa, and Lupron Depot — are real medications that target similar hormonal pathways, but they each come with their own pros, cons, and considerations.

Talk to your OB/GYN or reproductive endocrinologist about which option makes the most sense for your situation. And in the meantime, keep checking Medfinder for Myfembree availability — it may be closer than you think.