Methergine (Methylergonovine) is an ergot alkaloid used to prevent postpartum hemorrhage. Learn its uses, dosage, side effects, cost, and more.
Methergine (Methylergonovine Maleate) is a prescription ergot alkaloid medication used to prevent and control postpartum hemorrhage — heavy bleeding that can occur after delivering a baby. It works by causing the uterus to contract firmly, which helps stop bleeding and supports the uterus in returning to its normal size.
If your doctor just prescribed Methergine, or you're trying to understand what it is before your delivery, this guide covers everything you need to know: what it's used for, how to take it, who should avoid it, and what it costs in 2026.
Here are the basics:
Methergine is FDA-approved for:
In simple terms: Methergine helps your uterus contract after you've had a baby, which stops heavy bleeding and helps your body recover.
In rare cases, Methergine has been used for:
Methergine comes in two forms:
This is the form you'd take at home after being discharged from the hospital:
The injectable form is typically given in the hospital:
Methergine is not safe for everyone. It is contraindicated (should not be used) in patients with:
Methergine also has serious drug interactions with CYP3A4 inhibitors including certain antibiotics (Erythromycin, Clarithromycin), HIV medications (Ritonavir, Indinavir, Nelfinavir), and antifungal drugs (Ketoconazole, Itraconazole, Voriconazole). These combinations are contraindicated.
Methergine can pass into breast milk. If you're breastfeeding, do not nurse within 12 hours of taking a dose. The medication may also suppress lactation in some women. Discuss timing with your doctor.
Common side effects include nausea, vomiting, abdominal cramping, headache, dizziness, and elevated blood pressure. Most are mild and temporary.
Serious side effects are rare but can include severe hypertension, heart attack, stroke, coronary artery spasm, and dangerous heart rhythm changes. For a complete breakdown, read our guide on Methergine side effects.
The cost of Methergine varies significantly depending on where you fill your prescription and whether you use a discount card:
There is no manufacturer savings program since the brand-name Methergine has been discontinued. However, discount cards can dramatically reduce the out-of-pocket cost. For a full guide on savings options, read how to save money on Methergine.
Because Methergine is a niche obstetric medication with limited manufacturers, it can be hard to find in stock at some pharmacies. Use Medfinder to check which pharmacies near you have it available, or read our guide on how to check pharmacy stock without calling.
If Methergine isn't available or isn't right for you, your doctor may consider these alternatives:
Methergine is a well-established medication that has been used for decades to prevent and control postpartum hemorrhage. While the brand name has been discontinued, generic Methylergonovine remains available and effective.
If you've been prescribed Methergine, the most important things to know are: take it as directed, watch for side effects (especially blood pressure changes), tell your doctor about all other medications you're taking, and don't breastfeed within 12 hours of a dose.
Need help finding it? Search for Methergine on Medfinder to find a pharmacy near you with it in stock.
You focus on staying healthy. We'll handle the rest.
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