Trifluridine Availability in 2026: What's Going On?

If you've recently tried to fill a prescription for Trifluridine ophthalmic solution and been told it's unavailable, you're not imagining things. Trifluridine — the antiviral eye drop used to treat herpes simplex keratitis — has been experiencing intermittent availability issues that have left patients scrambling to find it.

In this article, we'll break down the current status of Trifluridine availability, explain why this keeps happening, and give you practical steps to get the treatment you need.

Is Trifluridine Still in Shortage?

Trifluridine has experienced periodic supply disruptions over the past several years. While it may not always appear on the FDA's official drug shortage list, the reality on the ground tells a different story. Many patients and pharmacists report difficulty sourcing Trifluridine 1% ophthalmic solution consistently.

The situation in early 2026 remains challenging. Only a small number of manufacturers — including Sandoz and Apotex — produce generic Trifluridine. The original brand-name product, Viroptic, is distributed by Pfizer but has also faced availability issues. When one manufacturer has a production disruption, the remaining suppliers often can't keep up with demand.

Why Is Trifluridine Hard to Find?

Several factors contribute to the ongoing availability challenges:

• Limited manufacturers: With only two or three companies producing generic Trifluridine, any production issue at a single facility can create nationwide shortages.
• Niche medication: Trifluridine treats a specific condition (herpes simplex eye infections), so production volumes are small. Manufacturers have less financial incentive to maintain large inventories.
• Cold storage requirements: Trifluridine must be refrigerated at 36°–46°F. This adds complexity and cost to manufacturing, distribution, and pharmacy storage.
• Industry consolidation: Akorn Pharmaceuticals (formerly Hi-Tech), once a key manufacturer, ceased operations in recent years. This reduced the number of available suppliers even further.

For a deeper dive into these supply issues, read our article on why Trifluridine is so hard to find.

How Much Does Trifluridine Cost in 2026?

Cost is another challenge for patients dealing with Trifluridine shortages. Here's what you can expect to pay:

• Retail cash price: Approximately $300 to $400 for a single 7.5 mL bottle
• With discount coupons: As low as $201 through services like SingleCare
• With insurance: Most commercial insurance plans and Medicare Part D cover generic Trifluridine, though copays vary. Brand-name Viroptic may not be covered.

For tips on reducing your costs, check out our guide on how to save money on Trifluridine.

Are There Any New Options in 2026?

While no new generic manufacturers have entered the Trifluridine market recently, patients do have alternative treatment options:

• Ganciclovir gel (Zirgan): An FDA-approved topical antiviral for herpetic keratitis that may be easier to find
• Oral Acyclovir or Valacyclovir: Widely available and affordable oral antivirals that can treat herpes eye infections

Read more about these options in our alternatives to Trifluridine guide.

How to Find Trifluridine in Stock Right Now

If you need Trifluridine today, here's your action plan:

1. Search on Medfinder: Visit medfinder.com to check real-time pharmacy availability near your zip code.
2. Call independent pharmacies: They often have different supply chains than major chains and may have stock when others don't.
3. Contact hospital outpatient pharmacies: Hospitals that treat eye emergencies are more likely to keep Trifluridine on hand.
4. Ask your ophthalmologist: Their office may have samples or know which pharmacies in the area typically stock it.
5. Consider a wider search radius: A pharmacy 20–30 minutes away may have what you need.

For more detailed strategies, read our full guide on how to find Trifluridine in stock near you.

Final Thoughts

The Trifluridine supply situation in 2026 continues to be unpredictable. Limited manufacturers, cold storage requirements, and industry consolidation all contribute to intermittent availability. While we hope for improvement, the best thing you can do right now is stay informed and have a backup plan.

Use Medfinder to track availability, talk to your ophthalmologist about alternative treatments, and don't wait until you're out of medication to start looking for your next refill.