Trifluridine can cost $300-$400 without insurance. Learn how to save with coupons, discount cards, patient assistance programs, and other strategies.
If you've just seen the price tag on Trifluridine ophthalmic solution, you might be in shock. A single 7.5 mL bottle of this antiviral eye drop can cost between $300 and $400 at retail price without insurance. For a medication you may need urgently to protect your vision, that's a tough pill to swallow — or rather, a tough drop to afford.
The good news is that there are several ways to bring down the cost of Trifluridine significantly. From free discount coupons to patient assistance programs, this guide covers every option available in 2026.
Let's start with the baseline. Here's what you can expect to pay for Trifluridine 1% ophthalmic solution (7.5 mL bottle) without any insurance or discounts:
Prices vary by pharmacy, so shopping around can save you money even before applying any coupons or discounts.
Prescription discount cards are the fastest and easiest way to save on Trifluridine. These are free to use, require no insurance, and work at most major pharmacies.
SingleCare currently offers Trifluridine 1% ophthalmic solution (7.5 mL) for as low as $201.68 — a savings of over $160 off the retail price. Simply search for Trifluridine on singlecare.com, show the coupon at your pharmacy, and pay the discounted price.
GoodRx frequently offers competitive pricing on Trifluridine. Prices vary by pharmacy location, but you can typically find savings of 30% to 50% off the cash price. Check goodrx.com for current pricing at pharmacies near you.
Additional discount card programs to check include:
Pro tip: Prices on discount cards change frequently. Check two or three different services before filling your prescription to find the best deal that day.
If you're uninsured or underinsured and can't afford Trifluridine even with discount coupons, patient assistance programs (PAPs) may be able to help. These programs provide medications for free or at very low cost to qualifying patients.
Pfizer, which distributes brand-name Viroptic, offers the RxPathways program to help eligible patients access Pfizer medications. Eligibility is typically based on income and insurance status. Visit pfizerrxpathways.com or call their helpline to learn more.
NeedyMeds (needymeds.org) is a nonprofit that maintains a database of patient assistance programs, discount drug cards, and other resources. Search for Trifluridine to see what programs are currently available.
RxAssist (rxassist.org) is another comprehensive database of patient assistance programs. It's maintained by Volunteers in Health Care and is free to search.
Many states offer their own pharmaceutical assistance programs for residents who meet income requirements. Check with your state's Department of Health or use the Medicare.gov State Pharmaceutical Assistance Programs finder.
If you have health insurance, Trifluridine is likely covered — but the details matter:
Important: Even with insurance, compare your copay to discount card prices. In some cases, using a SingleCare or GoodRx coupon may actually be cheaper than your insurance copay, especially if you have a high-deductible plan.
Always make sure your prescription is written for generic Trifluridine, not brand-name Viroptic. The generic is the same medication at a significantly lower price. Most pharmacists will automatically substitute the generic unless the prescription specifies "brand only."
Trifluridine prices can vary by $50 to $100 or more between pharmacies in the same area. Independent pharmacies and warehouse clubs (like Costco, which doesn't require a membership for pharmacy purchases) may offer lower prices than chain pharmacies.
Some ophthalmology practices keep Trifluridine samples from manufacturer representatives. If you're in a financial bind, ask your doctor if they have any samples to get you started on treatment while you explore cost-saving options.
If cost is a major barrier, discuss alternatives with your ophthalmologist:
Read our full guide on alternatives to Trifluridine for more details.
Trifluridine is an important medication, and its price shouldn't prevent you from getting the treatment you need. Start by checking discount card prices on SingleCare and GoodRx — you could save over $160 per bottle. If you're uninsured or struggling financially, patient assistance programs from Pfizer RxPathways, NeedyMeds, and RxAssist can help.
To find the best price at a pharmacy near you, visit Medfinder. For more information on availability, check out:
You focus on staying healthy. We'll handle the rest.
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