Natamycin in 2026: Is There Still a Shortage?

If you rely on Natamycin (brand name Natacyn) to treat a fungal eye infection, you've probably experienced the frustration of being told it's out of stock. For years, patients across the United States have dealt with difficulty finding this critical medication. But is Natamycin actually in shortage right now? And what does the landscape look like in 2026?

In this post, we'll give you the latest information on Natamycin availability, explain why it's been hard to find, cover the current cost picture, and share practical steps you can take to get the medication you need.

Is Natamycin Currently in Shortage?

As of early 2026, Natamycin is not officially listed on the FDA Drug Shortage database. This means the FDA considers the market supply adequate based on manufacturer reports. However, "not in shortage" on the FDA's list doesn't always reflect the reality at your local pharmacy.

Natamycin has always been difficult to find at retail pharmacies — not because of a manufacturing shortage, but because of the drug's unique market position:

• It's a single-source brand product (only Natacyn by Alcon, no generic)
• Fungal eye infections are relatively rare, so demand is low and unpredictable
• Most pharmacies don't stock it routinely due to low demand and high cost

So even when supply is technically available from the manufacturer, individual patients can still struggle to find a pharmacy that has it on the shelf.

Why Has Natamycin Been Hard to Find?

Natamycin's availability challenges aren't new. Here are the main factors that have contributed to difficulty finding this medication over the years:

Single Manufacturer

Alcon Laboratories is the sole manufacturer of Natacyn in the United States. With no generic competition, any production hiccup — whether related to raw materials, quality control, or logistics — can temporarily reduce supply nationwide.

Specialty Distribution

Natamycin is typically distributed through specialty pharmacy channels rather than standard retail wholesalers. This means your neighborhood CVS or Walgreens may not even be able to order it through their usual supply chain.

Intermittent Manufacturing Disruptions

Over the years, there have been periodic reports of Natamycin supply disruptions. While these haven't always risen to the level of an official FDA shortage designation, they've been enough to leave patients and providers scrambling for alternatives.

Low Inventory Buffers

Because Natamycin serves a small patient population, neither the manufacturer nor distributors maintain large inventory buffers. A small spike in demand — such as an outbreak of Fusarium keratitis — can quickly deplete available stock.

For a deeper dive into these supply dynamics, read our post on why Natamycin is so hard to find.

What Does Natamycin Cost in 2026?

The cost of Natamycin remains high. Here's what you can expect to pay:

• Cash price (without insurance): $250 to $600 for a 15 mL bottle of Natacyn 5%
• With insurance: Coverage varies widely. Many plans cover Natamycin with prior authorization, but copays can still range from $50 to $200 depending on your formulary tier
• No generic available: There is currently no FDA-approved generic Natamycin, which keeps prices elevated

If cost is a barrier, our guide on how to save money on Natamycin covers discount cards, patient assistance programs, and other strategies to reduce your out-of-pocket expense.

Are There New Options in 2026?

While no new FDA-approved Natamycin products have entered the U.S. market as of early 2026, there are some developments worth noting:

• Compounded antifungal eye drops continue to be widely used as alternatives when Natamycin is unavailable. Voriconazole 1% and Amphotericin B 0.15% eye drops are the most common compounded options.
• Clinical research into new antifungal delivery systems (such as nanoparticle-based formulations) continues, though none have reached FDA approval yet.
• Increased awareness among ophthalmologists about supply challenges has led many practices to establish relationships with specialty pharmacies that reliably stock Natamycin.

For a full comparison of alternatives, see our post on alternatives to Natamycin.

How to Find Natamycin in Stock Right Now

If you need Natamycin today, here are the most effective steps you can take:

1. Search Medfinder — check real-time pharmacy availability in your area
2. Call specialty pharmacies — especially those affiliated with ophthalmology practices or academic medical centers
3. Ask your ophthalmologist — they often know which pharmacies have stock and may have samples for urgent cases
4. Try hospital outpatient pharmacies — large hospitals are more likely to stock Natamycin
5. Consider mail-order specialty pharmacies — they can ship to your home within one to two business days

For a complete step-by-step guide, read our post on how to find Natamycin in stock near you.

Final Thoughts

While Natamycin is not officially in shortage as of 2026, the practical reality is that it remains one of the harder medications to find at a pharmacy. Its single-source status, niche market, specialty distribution, and high cost all contribute to ongoing availability challenges.

The good news is that the medication is being manufactured, and with the right tools and strategy, most patients can locate it within a day or two. Start with Medfinder, work with your ophthalmologist, and don't hesitate to explore compounded alternatives if you need treatment right away.

Fungal eye infections are serious and time-sensitive. Don't wait — take action today to secure the treatment you need.