How to Save Money on Paromomycin in 2026: Coupons, Discounts, and Patient Assistance

Paromomycin is one of the most expensive antiparasitic drugs in the United States — not because it's a cutting-edge biologic, but because there's no generic competition. With only brand-name Humatin available, a bottle of 100 capsules (250 mg each) can cost more than $12,000 at cash price at some pharmacies. A full treatment course for a typical adult can run into thousands of dollars.

The good news: there are legitimate programs that can dramatically reduce what you actually pay — sometimes to as little as $5 per prescription. Here's how.

Why Is Paromomycin So Expensive?

Generic paromomycin no longer exists in the US. The only generic manufacturer, Avet Pharmaceuticals, discontinued its product in September 2021. With Waylis Therapeutics as the sole supplier of Humatin, there is no price competition. Antiparasitic drugs also have small patient populations, meaning the fixed costs of manufacturing are spread over fewer units — pushing prices up.

Option 1: Humatin TotalCare Copay Savings Card

This is the most impactful savings option for commercially insured patients. The Humatin TotalCare program, offered by Waylis Therapeutics, allows eligible patients to pay as little as

$5 per prescription — regardless of the pharmacy's cash price.

To use the savings card, provide the following information to your pharmacist:

BIN: 610600

PCN: AS

RxGroup: 373

ID: 37305128031

Eligible patients must have commercial insurance. The card is not valid for Medicare, Medicaid, TRICARE, or similar federal healthcare programs. Annual, monthly, and per-fill program limits apply.

Option 2: Humatin Patient Assistance Program (Free Medication)

If you are uninsured and do not have Medicare or TRICARE, you may qualify to receive Humatin at

no charge through Waylis Therapeutics' patient assistance program. To apply:

Download the Patient Assistance Form at humatintotalcare.com

Complete the form with your prescriber's signature

Fax to 844-470-1931

Enrollment requirements and processing times apply. Your prescriber's office may be able to assist with completing the form.

Option 3: Use Insurance — But Know the Steps

Most commercial insurance plans cover Humatin, but prior authorization is typically required. Your out-of-pocket cost with insurance will depend on your plan's tier structure — Humatin is typically placed on Tier 3 or Tier 4. After prior auth is approved and you apply the copay card, many insured patients end up paying very little out of pocket.

Important steps: ask your prescriber to submit prior authorization at the time of prescribing. Provide the copay savings card details to your pharmacist when you pick up.

Option 4: Ask Your Prescriber About Medicare/Medicaid Extra Help

If you have Medicare Part D, the Humatin TotalCare copay card is not available to you (per federal regulations). However, the Medicare Extra Help / Low-Income Subsidy (LIS) program can significantly reduce drug costs for qualifying enrollees. Your state may also have a State Pharmaceutical Assistance Program (SPAP) — check Medicare's online tool to see if your state participates.

First, Find a Pharmacy That Has It in Stock

Even the best savings program doesn't help if you can't find the medication.

medfinder is a paid service that calls pharmacies in your area to find which ones have Humatin in stock and can fill your prescription. Once you know where to go, you can apply your savings card and save significantly.

Also see: How to Find Paromomycin in Stock Near You for step-by-step guidance.