How to Save Money on Epclusa in 2026: Coupons, Discounts, and Patient Assistance

Epclusa has a list price of approximately $24,350 for a 28-day supply — meaning a full 12-week course can cost more than $78,000 at retail. Those numbers are staggering. But here's the reality: the vast majority of patients do NOT pay the list price. Multiple programs exist to dramatically reduce — and in some cases eliminate — your out-of-pocket cost. Here's how to access them in 2026.

Option 1: Gilead's Support Path Co-Pay Savings Card

If you have commercial (private or employer-based) health insurance, the Epclusa Co-Pay Savings Card from Gilead's Support Path program can reduce your monthly cost to as little as $5 per month. The program covers up to 25% of the catalog price for three bottles over a 6-month period.

Eligibility requirements: Must have commercial insurance (employer-provided or marketplace plan), be a US citizen 18 or older (or an eligible minor), have a valid prescription for Epclusa, and not be covered by a government program like Medicare or Medicaid.

How to enroll: Visit MySupportPath.com or call 1-855-769-7284 (Monday–Friday, 9 AM–8 PM ET).

Option 2: Gilead Patient Assistance Program (For Uninsured Patients)

If you have no insurance, the Epclusa Patient Assistance Program (PAP) through Gilead's Support Path may provide the medication at no charge. The program is designed for patients who meet income and eligibility requirements — generally individuals earning under a certain annual threshold (requirements vary and can be confirmed by calling Support Path).

To apply, contact Support Path at 1-855-769-7284 or visit MySupportPath.com. You will need to complete an application and provide income documentation.

Option 3: Medicaid Coverage

Epclusa is covered by Medicaid in all 50 states. Most state Medicaid programs have copays of $0–$5 for Epclusa, making it highly accessible for qualifying low-income patients. Based on 2025 data from Gilead Sciences, Medicaid patient coverage is broad, with many patients paying as little as $0.

If you don't currently have Medicaid, check your eligibility at HealthCare.gov or your state's Medicaid website. This is often the best path to affordable hepatitis C treatment for uninsured patients with lower incomes.

Option 4: Medicare Part D Coverage

Epclusa is covered by Medicare Part D plans. In 2026, the annual out-of-pocket cap for all Part D drugs is $2,100. Once you reach that cap, your plan covers 100% of the cost for the rest of the year. This is a significant improvement from prior years and makes Epclusa much more accessible for Medicare patients.

If you have Medicare and limited income, the Medicare Extra Help program (Low Income Subsidy) can further reduce your Part D costs. Apply through Social Security Administration.

Option 5: The Authorized Generic (Lower List Price)

Asegua Therapeutics (a Gilead affiliate) sells an authorized generic of Epclusa with a list price of approximately $6,728 for 28 tablets — about $20,000 less than brand Epclusa per month. The active ingredients, safety, and efficacy are identical to the brand.

The authorized generic is particularly relevant for cash-paying patients or those whose insurance may cover a generic but not a brand-name drug. Ask your pharmacy specifically whether they carry the Asegua-branded authorized generic.

Option 6: Discount Cards (GoodRx, SingleCare, RxSaver)

Discount card services like GoodRx and SingleCare negotiate discounted rates at participating pharmacies. SingleCare has advertised savings of up to $20,000 off the retail price of Epclusa for a four-week supply, though these cards reflect the price of the authorized generic.

Keep in mind: discount cards are not compatible with insurance. You can't use a GoodRx card and your insurance on the same prescription. For most insured patients, going through your insurance will yield lower cost. Use discount cards only if you're paying cash or your insurance doesn't cover Epclusa.

Option 7: AIDS Drug Assistance Program (ADAP)

If you have both hepatitis C and HIV, you may qualify for ADAP (AIDS Drug Assistance Program), which is included in the Epclusa formulary. Run by the US Department of Health and administered by individual states, ADAP provides free HIV/AIDS prescription medications to uninsured or underinsured patients. Contact your state or local health department to learn about enrollment.

Option 8: Nonprofit and Disease-Specific Assistance

Several nonprofit organizations offer additional financial assistance for hepatitis C patients:

• American Liver Foundation — resources and referrals for liver disease patients
• Hepatitis Foundation International — patient support and advocacy
• NeedyMeds.org — database of patient assistance programs and drug discount cards
• RxAssist.org — comprehensive database of pharmaceutical assistance programs

The Bottom Line on Epclusa Cost

The list price of Epclusa is misleading — most patients with insurance pay a fraction of that amount, and many qualifying patients can access it at little to no cost through patient assistance programs or Medicaid. Don't let sticker shock stop you from pursuing treatment. And once you have the financial piece sorted out, use medfinder to locate a pharmacy that has your prescription ready. See our related guide on how to find Epclusa in stock near you.