Helping Patients Find Hyperrho: A Practical Guide for Providers

Your patient is Rh-negative, she's at 27 weeks, and her pharmacy just called to say Hyperrho is on backorder. She's anxious. You're frustrated. And the clock is ticking toward her 28-week immunoprophylaxis window.

This scenario has played out in OB-GYN offices across the country over the past two years. The intermittent shortage of Rho(D) immune globulin products — including Hyperrho (HyperRHO S/D by Grifols) — has added an unwelcome layer of complexity to routine prenatal care.

This guide offers a step-by-step approach to helping your patients find Hyperrho or an equivalent product, along with workflow tips to stay ahead of supply disruptions.

Current Availability Snapshot

As of early 2026, Rho(D) immune globulin supply is improved but not fully normalized. Here's a quick brand-by-brand overview:

• Hyperrho (Grifols): Intermittently available, with better availability through hospital and specialty distributors than retail chains
• RhoGAM (Kedrion Biopharma): Most widely available; remains the most commonly stocked product across retail and clinical settings
• WinRho SDF (Saol Therapeutics): Available primarily through hospital and specialty pharmacies; IV/IM dual route
• Rhophylac (CSL Behring): Moderate availability; IV/IM dual route

Regional variation is significant. A product that's readily available in one state may be backordered in the next. Real-time availability tracking is essential.

Why Your Patients Can't Find It

Patients face several obstacles that providers may not immediately see:

• Retail pharmacy limitations: Large chains rely on centralized distribution systems. When national supply is tight, retail locations are among the first to be affected.
• Brand-specific prescriptions: If you've prescribed "Hyperrho" specifically and it's unavailable, the pharmacy may not be able to substitute another Rho(D) immune globulin product without a new prescription or explicit authorization.
• Insurance hurdles: While most plans cover Rho(D) immune globulin, some may have preferred products or require documentation for a non-preferred brand. Patients may encounter delays navigating these requirements.
• Patient anxiety: Patients who've been told their medication is critical for their baby's health understandably panic when they can't find it. They may not know that alternative brands exist or that the products are interchangeable.

What Providers Can Do: 5 Steps

Step 1: Prescribe Generically When Possible

Write prescriptions for "Rho(D) Immune Globulin (Human), 300 mcg IM" rather than a specific brand. This gives the dispensing pharmacy maximum flexibility to fill with whatever product is available — Hyperrho, RhoGAM, WinRho SDF, or Rhophylac.

If your EHR requires a brand selection, add a note allowing therapeutic substitution. All FDA-approved Rho(D) immune globulin products are therapeutically equivalent for Rh immunoprophylaxis.

Step 2: Stock In-Office When Feasible

Many OB-GYN and maternal-fetal medicine practices administer Rho(D) immune globulin in the office, billing under the medical benefit. If your practice has the capability:

• Work with your distributor to maintain a small buffer stock
• Diversify across multiple brands — if your primary product is backordered, having a secondary option prevents gaps
• Monitor expiration dates and rotate stock appropriately

In-office administration also simplifies the patient experience and eliminates the retail pharmacy as a point of failure.

Step 3: Use Real-Time Availability Tools

Medfinder for Providers allows you to search for medication availability by location in real time. You or your staff can:

• Search for Rho(D) immune globulin availability near your practice or your patient's zip code
• Identify pharmacies that currently have stock
• Direct patients to specific locations rather than sending them on a wild goose chase

Having this tool in your workflow can save significant time for both your team and your patients.

Step 4: Coordinate with Hospital Pharmacy

If your practice is affiliated with a hospital, the hospital pharmacy likely maintains its own stock of Rho(D) immune globulin for labor and delivery. In many cases, the outpatient pharmacy or infusion center can administer the antepartum dose, especially if retail availability is problematic.

Establish a workflow with your hospital pharmacy so that when retail sources fail, there's a clear backup pathway for your patients.

Step 5: Educate Your Patients Proactively

Many patients don't know that:

• Multiple equivalent brands exist
• Their doctor's office may be able to administer the injection directly
• Tools like Medfinder can help them find stock

Consider providing a brief handout or mentioning these points at a prenatal visit before the 28-week dose is due. Proactive communication reduces anxiety and prevents last-minute scrambles.

Alternatives to Hyperrho

For a detailed comparison, see our patient-facing alternatives guide. In summary:

• RhoGAM (Kedrion): IM only, 300 mcg and 50 mcg options, most widely available
• WinRho SDF (Saol): IV or IM, multiple strengths, boxed warning for hemolysis with IV use in ITP
• Rhophylac (CSL Behring): IV or IM, 300 mcg prefilled syringe

All products are therapeutically equivalent for Rh immunoprophylaxis. The choice between them should be guided primarily by availability, with route of administration and clinical context as secondary factors.

Workflow Tips

Here are practical ways to integrate shortage management into your practice workflow:

• Flag Rh-negative patients early: At the initial prenatal visit, identify Rh-negative patients and plan ahead for their immunoprophylaxis needs.
• Set calendar reminders: At 24-25 weeks, initiate the process of sourcing Rho(D) immune globulin so there's time to find stock before the 28-week window.
• Designate a staff member: Having one team member responsible for tracking Rho(D) immune globulin availability and managing orders can prevent gaps.
• Maintain a backup supplier list: Identify 2-3 pharmacies or distributors that reliably carry Rho(D) immune globulin and keep their contact information accessible.
• Document thoroughly: If a dose is delayed due to supply issues, document the clinical rationale, the steps taken to obtain the product, and the plan for administration.

Final Thoughts

The Hyperrho shortage is a logistical challenge, not a clinical impossibility. With generic prescribing, proactive sourcing, in-office stocking, and patient education, you can ensure your Rh-negative patients receive timely immunoprophylaxis even when supply is tight.

Leverage tools like Medfinder for Providers to streamline the process and reduce the burden on your staff and patients. For the broader shortage context, see our provider shortage briefing.