How to Help Your Patients Save Money on Paromomycin: A Provider's Guide to Savings Programs

Prescribing paromomycin today means confronting a difficult reality: for many patients, cost will be the biggest barrier to treatment — bigger even than the difficulty of finding a pharmacy that stocks it. With no generic available and only brand-name Humatin on the market, a 100-capsule bottle can carry a list price of over $12,000 at some pharmacies. This guide walks through every financial resource available to help your patients access paromomycin affordably.

Understanding the Cost Problem

Generic paromomycin was discontinued in September 2021 when Avet Pharmaceuticals exited the market. With Waylis Therapeutics as the only US supplier of Humatin, there is no price competition. Researchers have documented the cost burden of antiparasitic drugs in the US — with some patient populations facing thousands of dollars out of pocket even with insurance if prior authorization is delayed or denied.

The situation disproportionately affects lower-income patients, immigrants, and patients who are uninsured or underinsured — precisely the populations most likely to need antiparasitic treatment in the US context. As the prescribing provider, proactively enrolling patients in savings programs is one of the highest-impact steps you can take.

Program 1: Humatin TotalCare Copay Savings Card (Commercially Insured Patients)

For patients with commercial insurance, this is the most effective tool you have. The Humatin TotalCare copay card, offered by Waylis Therapeutics, allows eligible patients to pay

as little as $5 per prescription — regardless of the drug's list price.

Pharmacy billing details to provide patients or your office staff:

BIN: 610600

PCN: AS

RxGroup: 373

ID: 37305128031

Eligibility: Commercial insurance only. Not valid for Medicare, Medicaid, TRICARE, or similar federal/state programs. Annual, monthly, and per-fill limits apply. No substitutions permitted.

Best practice: include the copay card details in your prescribing workflow. Have your medical assistant hand patients the savings card information at checkout or include it with the after-visit summary.

Program 2: Humatin Patient Assistance Program (Uninsured / Underinsured Patients)

Waylis Therapeutics offers a patient assistance program that can provide Humatin at no cost to patients who qualify. This program is specifically for patients who have:

No health insurance, and

No Medicare or TRICARE coverage

Process: Download the Patient Assistance Form from humatintotalcare.com. The form requires the prescriber's signature and NPI number. Completed forms should be faxed to 844-470-1931. Your office staff can complete and fax the form on the patient's behalf.

Note: enrollment requirements and processing times apply. For urgent cases, contact the TotalCare program directly for expedited options.

Navigating Insurance: Prior Authorization Best Practices

Nearly all commercial plans require prior authorization for Humatin. Streamlining this process reduces the gap between prescribing and treatment initiation. Key best practices:

Submit PA simultaneously with prescribing, not after a pharmacy rejection. PA approval typically takes 1–3 business days.

Include complete documentation: Diagnosis codes (ICD-10), microbiologic confirmation (stool O&P or PCR), and a brief statement that paromomycin is indicated per IDSA treatment guidelines.

Know the specialty pharmacy routing rules: Some plans route Humatin through specialty pharmacy networks. Confirm with the patient's insurer before sending the prescription to a retail pharmacy.

Appeal denials: First-line PA denials are common for antiparasitic drugs. A peer-to-peer review with the insurer's medical director citing IDSA guidelines often overturns initial denials.

For Medicare and Medicaid Patients

The Humatin TotalCare copay card is not available for Medicare or Medicaid beneficiaries. For Medicare Part D patients, explore:

Medicare Extra Help / Low-Income Subsidy (LIS): Substantially reduces Part D cost-sharing for qualifying low-income beneficiaries.

State Pharmaceutical Assistance Programs (SPAPs): Some states provide supplemental drug coverage for Medicare beneficiaries. Direct patients to Medicare's SPAP lookup tool.

For Medicaid patients: Paromomycin may be covered under Medicaid; consult the state Medicaid formulary. Some state programs may require step therapy or specialist documentation.

Helping Patients Find the Drug

Once cost is addressed, patients still need to find a pharmacy that stocks Humatin.

medfinder for providers is a paid service that calls pharmacies in the patient's area to find which ones have it available, with results texted directly to the patient. Recommending medfinder to your patients removes a significant logistical burden from their post-visit experience.

Summary: Provider Action Checklist for Paromomycin Savings

Identify insurance type: commercial, Medicare, Medicaid, or uninsured

For commercial patients: provide Humatin TotalCare copay card details (BIN 610600, PCN AS, RxGroup 373, ID 37305128031)

For uninsured patients: initiate patient assistance program enrollment — download form from humatintotalcare.com, fax to 844-470-1931

Submit prior authorization at time of prescribing — include diagnosis code, lab results, and IDSA guideline justification

Recommend medfinder to help patients locate a pharmacy with Humatin in stock

See also: How to Help Your Patients Find Paromomycin in Stock: A Provider's Guide for pharmacy sourcing strategies.