Comprehensive medication guide to Trivora 28 Day including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0 copay under the ACA contraceptive coverage mandate on most commercial plans; Tier 1–2 on most formularies; some plans may require prior authorization for specific brand generics.
Estimated Cash Pricing
$17–$89 per 28-tablet pack retail; as low as $17.44 with a GoodRx coupon or $13.03 with SingleCare at participating pharmacies (Feb 2026 data).
Medfinder Findability Score
73/100
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Trivora 28 Day is a prescription triphasic combination oral contraceptive containing levonorgestrel (a synthetic progestin) and ethinyl estradiol (a synthetic estrogen). It is FDA-approved for the prevention of pregnancy and is taken once daily for 28 consecutive days per menstrual cycle.
The 28-tablet pack consists of 6 blue tablets (Phase 1: 0.05 mg LNG / 0.03 mg EE), 5 white tablets (Phase 2: 0.075 mg LNG / 0.04 mg EE), 10 pink tablets (Phase 3: 0.125 mg LNG / 0.03 mg EE), and 7 peach inert placebo tablets. The triphasic design delivers varying hormone doses across the cycle, intended to mimic the body's natural hormonal fluctuations.
Trivora 28 Day is manufactured by Mayne Pharma and is a generic of the original Triphasil-28. It is clinically equivalent to other generics including Levonest-28, Myzilra-28, and the largely discontinued Enpresse-28 (Teva).
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Trivora 28 Day works through three complementary mechanisms to prevent pregnancy. The primary mechanism is suppression of ovulation: the progestin and estrogen in Trivora signal the brain to reduce production of FSH and LH — the hormones that trigger egg release. Without ovulation, fertilization cannot occur.
The levonorgestrel component also thickens cervical mucus, creating a physical barrier that prevents sperm from reaching any egg that might be released. As a third mechanism, the hormones alter the endometrial lining to make it less receptive to implantation of a fertilized egg.
The triphasic schedule of increasing doses across the 21 active tablets is designed to minimize total hormone exposure while maintaining strong contraceptive efficacy — though all three mechanisms are active throughout the cycle.
Phase 1: 0.05 mg LNG / 0.03 mg EE — tablet (blue)
6 tablets taken days 1-6 of the 28-day pack
Phase 2: 0.075 mg LNG / 0.04 mg EE — tablet (white)
5 tablets taken days 7-11 of the 28-day pack
Phase 3: 0.125 mg LNG / 0.03 mg EE — tablet (pink)
10 tablets taken days 12-21 of the 28-day pack
Inert — tablet (peach)
7 placebo tablets taken days 22-28 — no hormones
Trivora 28 Day is not on the FDA's official drug shortage list as of 2026. However, localized pharmacy stocking gaps are common, primarily because triphasic oral contraceptives represent a smaller market share than monophasic pills — leading many pharmacies to stock them less aggressively.
The availability situation has been complicated by the discontinuation of Enpresse-28 (Teva), which was an AB-rated equivalent to Trivora-28. As demand shifted to Trivora-28 and other generics, some pharmacy ordering systems — which were configured for Enpresse's NDC codes — did not automatically update, creating apparent unavailability even when equivalent stock exists nearby.
If you're having trouble finding Trivora 28 Day, medfinder can call pharmacies near you to find which ones have it in stock. You can also ask your pharmacist to search for any AB-rated generic of "levonorgestrel/ethinyl estradiol triphasic 28-day" — this covers Levonest, Myzilra, and other equivalents.
Trivora 28 Day is not a controlled substance, so any licensed prescriber with prescriptive authority can write a prescription for it. No special DEA registration or state-specific scheduling authorization is required beyond standard prescriptive authority.
Healthcare professionals who commonly prescribe Trivora 28 Day include:
Trivora 28 Day is widely available through telehealth services in 2026. Platforms including Nurx, Wisp, SimpleHealth, and Pandia Health can prescribe and dispense levonorgestrel/ethinyl estradiol triphasic oral contraceptives in most states through an online consultation.
No. Trivora 28 Day is not a controlled substance and is not assigned a DEA schedule. It is classified as a prescription-only medication, meaning it requires a valid prescription from a licensed prescriber, but it is not subject to the additional restrictions that apply to controlled substances (such as Schedule II-V drugs).
Because Trivora 28 Day is not a controlled substance, it can be prescribed by any licensed prescriber (including NPs and PAs) without special DEA registration requirements, refills can be authorized (up to 12 months per the ACA for contraceptives in most states), and prescriptions can be transmitted electronically or by fax without the restrictions that apply to controlled substances.
The following side effects are common when starting Trivora 28 Day and typically improve after the first 2-3 cycles:
Serious side effects requiring immediate medical attention:
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Levonest 28
AB-rated generic equivalent with identical triphasic levonorgestrel/ethinyl estradiol formulation — most seamless substitution
Myzilra 28
AB-rated generic with same triphasic LNG/EE dosing schedule as Trivora 28 Day
Tri-Sprintec
Triphasic norgestimate/ethinyl estradiol — different progestin, similar design and well-established safety profile
Levora 0.15/30
Monophasic levonorgestrel/ethinyl estradiol — same hormones in a simplified fixed daily dose
Prefer Trivora 28 Day? We can find it.
Rifampin / Rifabutin
majorPotent CYP3A4 inducers; significantly reduce levonorgestrel and ethinyl estradiol plasma levels, reducing contraceptive efficacy. Use backup contraception for at least 28 days after stopping.
Phenytoin (Dilantin)
majorAntiseizure enzyme inducer; reduces COC hormone levels and contraceptive effectiveness.
Carbamazepine (Tegretol)
majorAntiseizure/mood stabilizer; enzyme inducer that reduces Trivora plasma concentrations.
Ombitasvir/paritaprevir/ritonavir (Viekira Pak)
majorHepatitis C combination therapy; concurrent use with ethinyl estradiol can cause severe ALT elevations (>5x normal). Trivora must be discontinued before starting this HCV regimen.
Topiramate (Topamax)
moderateAt doses ≥200 mg/day, can reduce COC efficacy through enzyme induction. Backup contraception recommended.
St. John's Wort
moderateHerbal CYP3A4 inducer; can reduce estradiol levels by ~15%. Use backup contraception with regular use.
Barbiturates
moderateModerate CYP3A4 inducers; can reduce COC plasma concentrations.
Griseofulvin
moderateAntifungal; possible reduction in COC efficacy. Use backup contraception during treatment.
Trivora 28 Day is a well-established triphasic combination oral contraceptive with decades of clinical history. When taken correctly, it is highly effective for preventing pregnancy. Most patients tolerate it well, with common side effects diminishing after the first few cycles. Its triphasic design aims to minimize hormone exposure while maintaining strong contraceptive efficacy.
The primary challenge with Trivora 28 Day in 2026 is not its safety or efficacy — it's local pharmacy availability. Stocking gaps related to the discontinuation of the equivalent Enpresse-28 brand mean that your usual pharmacy may not have it in stock, even though it remains available elsewhere. Asking for the generic by description (levonorgestrel/ethinyl estradiol triphasic 28-day) and using pharmacy-finding tools can usually resolve availability challenges.
If you're having trouble locating Trivora 28 Day near you, medfinder can call pharmacies near you to find which ones have it in stock, so you can fill your prescription without missing a dose.
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