Comprehensive medication guide to Afinitor including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$4,800/month
Estimated Cash Pricing
$90–$19,300/month
Medfinder Findability Score
62/100
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Afinitor is the brand name for Everolimus, a targeted cancer therapy classified as an mTOR (mammalian target of rapamycin) kinase inhibitor. It is manufactured by Novartis Pharmaceuticals. Afinitor is FDA-approved for several conditions:
Afinitor works by slowing or stopping the growth of cancer cells and tumors. It is taken as a once-daily oral tablet.
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Afinitor tablets
2.5 mg, 5 mg, 7.5 mg, 10 mg
Afinitor Disperz tablets for oral suspension — suspension
2 mg, 3 mg, 5 mg
Afinitor has a significant side effect profile. The most commonly reported side effects include:
Serious side effects to watch for include non-infectious pneumonitis (lung inflammation, potentially fatal), serious infections, renal failure, high blood sugar, high cholesterol, and low blood counts. Contact your doctor immediately if you experience new or worsening cough, shortness of breath, or fever.
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Temsirolimus (Torisel)
another mTOR inhibitor given by IV infusion, used for advanced renal cell carcinoma
Sirolimus (Rapamune)
a related mTOR inhibitor, primarily used in organ transplant but investigated in TSC
Sunitinib (Sutent)
a tyrosine kinase inhibitor used for pancreatic neuroendocrine tumors and renal cell carcinoma
Palbociclib (Ibrance)
a CDK4/6 inhibitor used for HR+/HER2- breast cancer as an alternative targeted therapy
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Strong CYP3A4 inhibitors
moderate(Ketoconazole, Itraconazole, Clarithromycin, Ritonavir, Voriconazole) — significantly increase Everolimus levels and toxicity risk
Strong CYP3A4 inducers
moderate(Rifampin, Phenytoin, Carbamazepine, Phenobarbital, St. John's Wort) — significantly decrease Everolimus levels, reducing effectiveness
Live vaccines
moderateavoid due to immunosuppressive effects of Everolimus
Moderate CYP3A4 inhibitors
moderate(Erythromycin, Fluconazole, Verapamil, Diltiazem) — may require Everolimus dose reduction
ACE inhibitors
moderate(Lisinopril, Enalapril) — increased risk of angioedema
Grapefruit and grapefruit juice
moderateincreases Everolimus levels; avoid completely
Seville oranges and starfruit
moderatemay also increase drug levels
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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