Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Afinitor is the brand name for Everolimus, a targeted cancer therapy classified as an mTOR (mammalian target of rapamycin) kinase inhibitor. It is manufactured by Novartis Pharmaceuticals. Afinitor is FDA-approved for several conditions:
Afinitor works by slowing or stopping the growth of cancer cells and tumors. It is taken as a once-daily oral tablet.
Afinitor (Everolimus) works by inhibiting the mTOR protein, a key regulator of cell growth, proliferation, and survival. Here's how it works:
This targeted mechanism helps slow tumor growth across multiple cancer types. Unlike traditional chemotherapy, Afinitor specifically targets the mTOR signaling pathway rather than broadly killing rapidly dividing cells, though it still has significant side effects due to its immunosuppressive properties.
Most adult oncology patients take 10 mg once daily. Patients with tuberous sclerosis complex (TSC) — including SEGA and TSC-related seizures — are dosed based on body surface area, typically starting at 5 mg/m² once daily, with adjustments based on blood trough levels.
Afinitor (Everolimus) is a specialty oncology medication that is not typically stocked at retail pharmacies. It is dispensed through specialty pharmacies, which manage inventory for high-cost, limited-distribution drugs. As of 2026, there is no active FDA shortage of Afinitor or generic Everolimus, and multiple generic manufacturers produce Everolimus tablets. However, because it requires specialty pharmacy dispensing, you generally cannot walk into a neighborhood pharmacy and pick it up. Your oncologist's office will typically coordinate with a specialty pharmacy to arrange delivery. The Afinitor Disperz formulation (tablets for oral suspension) may have slightly more limited availability compared to standard tablets.
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Afinitor is a specialty medication prescribed by physicians who manage the specific conditions it treats:
Afinitor is not available via telehealth and requires in-person specialist evaluation, regular blood work monitoring, and ongoing management due to its serious side effect profile.
No, Afinitor is not a controlled substance. It does not have a DEA schedule and is not subject to the prescribing restrictions that apply to controlled medications. However, it is a high-risk specialty medication that requires close medical supervision, regular blood monitoring, and is typically only dispensed through specialty pharmacies with specific handling and distribution requirements.
Afinitor has a significant side effect profile. The most commonly reported side effects include:
Serious side effects to watch for include non-infectious pneumonitis (lung inflammation, potentially fatal), serious infections, renal failure, high blood sugar, high cholesterol, and low blood counts. Contact your doctor immediately if you experience new or worsening cough, shortness of breath, or fever.
Depending on the condition being treated, alternatives to Afinitor may include:
Your oncologist or specialist will determine the most appropriate treatment based on your specific cancer type, prior treatments, and overall health. Always discuss alternatives with your care team before making any changes.
Afinitor has several important drug interactions because it is metabolized by the CYP3A4 enzyme system:
Always inform your doctor and pharmacist of all medications, supplements, and herbal products you take.
Afinitor (Everolimus) is a powerful targeted therapy that has made a meaningful difference for patients with several types of cancer and tuberous sclerosis complex. While it is not currently in shortage and generic Everolimus is available, the high cost and specialty pharmacy requirement can make access challenging.
Key tips for accessing Afinitor:
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