Comprehensive medication guide to Adthyza including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$20–$50/month
Estimated Cash Pricing
$29–$38/month
Medfinder Findability Score
2/100
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Adthyza was a natural desiccated thyroid (NDT) medication manufactured by Azurity Pharmaceuticals (formerly Silvergate Pharmaceuticals). It contained both levothyroxine (T4) and liothyronine (T3) derived from porcine (pig) thyroid glands. Adthyza was prescribed for the treatment of hypothyroidism — a condition where the thyroid gland doesn't produce enough thyroid hormones.
Adthyza was also used for pituitary TSH suppression in patients with thyroid nodules or multinodular goiter, and as a diagnostic agent in thyroid suppression tests. Some patients and providers preferred NDT products like Adthyza because they provide both T4 and T3 hormones, rather than T4 alone as with synthetic levothyroxine.
Note: Adthyza was discontinued in late November 2025 and is no longer available.
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¼ grain / 16.25 mg (9.5 mcg T4 + 2.25 mcg T3)
½ grain / 32.5 mg (19 mcg T4 + 4.5 mcg T3)
1 grain / 65 mg (38 mcg T4 + 9 mcg T3)
1½ grains / 97.5 mg (57 mcg T4 + 13.5 mcg T3)
2 grains / 130 mg (76 mcg T4 + 18 mcg T3)
Seek immediate medical attention if you experience chest pain, rapid or irregular heartbeat, shortness of breath, excessive sweating, severe tremor, or signs of thyroid toxicity. Long-term overtreatment can lead to bone density loss and cardiovascular complications.
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Armour Thyroid
(NDT by AbbVie) — The most well-known desiccated thyroid product, widely available at $35–$43/month. Most direct substitute for Adthyza.
NP Thyroid
(NDT by Acella Pharmaceuticals) — Similar NDT with fewer inactive ingredients, $24–$40/month. Previously recalled for sub-potency but returned to market.
Levothyroxine (Synthroid, Levoxyl, Tirosint)
Synthetic T4 only, the standard first-line treatment for hypothyroidism. Widely available and affordable at $4–$30/month for generic.
Liothyronine (Cytomel)
Synthetic T3 that can be combined with Levothyroxine to mimic the T4/T3 ratio found in NDT products, $10–$40/month for generic.
Prefer Adthyza? We can find it.
Warfarin and anticoagulants
moderateThyroid hormones can increase bleeding risk; INR monitoring and dose adjustments may be needed
Insulin and diabetes medications
moderateThyroid hormones affect blood sugar levels; diabetes medication doses may need adjustment
Cholestyramine and Colestipol
moderateSignificantly reduce thyroid hormone absorption; take at least 4 hours apart
Oral estrogens and birth control pills
moderateCan increase thyroid-binding globulin, reducing free hormone levels
Calcium supplements and antacids
moderateReduce absorption; separate by at least 4 hours
Iron supplements
moderateReduce absorption; take at least 4 hours apart
Amiodarone
moderateContains iodine and can affect thyroid function
Lithium
moderateMay cause hypothyroidism and alter thyroid hormone levels
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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