Find out why Nayzilam (Midazolam nasal spray) is so hard to find in 2026, what's causing supply issues, and what you can do to get your seizure rescue medication.
If you or a loved one relies on Nayzilam (Midazolam nasal spray) to treat seizure clusters, you may have experienced the frustration of going to the pharmacy only to hear those dreaded words: "We don't have it in stock." You're not alone. Many patients across the country have struggled to find Nayzilam in 2026, and there are real reasons behind the shortage.
In this article, we'll explain why Nayzilam is hard to find, what's driving the supply issues, and what steps you can take to get your medication.
Nayzilam is a prescription nasal spray containing Midazolam, a benzodiazepine medication. It was approved by the FDA in May 2019 for the acute treatment of seizure clusters (also called acute repetitive seizures) in patients 12 years of age and older. Unlike older rescue medications like Diastat (rectal Diazepam), Nayzilam is sprayed into the nose, making it much easier and more dignified to use — especially in public or at school.
For people with epilepsy who experience seizure clusters, having a rescue medication like Nayzilam available at all times can be a matter of life and death. When this medication isn't available, patients are left vulnerable.
Nayzilam is made by only one company: UCB Pharma. There is no generic version of Nayzilam available as of 2026. When a drug has only one manufacturer, any disruption in production — whether from equipment issues, raw material shortages, or quality control problems — can affect the entire supply chain.
Nayzilam is a Schedule IV controlled substance, which means it has additional regulations around how it's stored, distributed, and dispensed. Many regular retail pharmacies don't routinely stock it because demand is relatively low compared to everyday medications. Specialty pharmacies are more likely to carry it, but not every patient has easy access to one.
Like many medications in recent years, Nayzilam has been affected by broader supply chain disruptions. These can include shortages of raw ingredients, shipping delays, and regulatory inspections that temporarily slow production.
Even when Nayzilam is physically available, many insurance plans require prior authorization before they'll cover it. This adds days or even weeks to the process of filling a prescription. Some plans also require step therapy, meaning you may need to try other rescue medications first. These bureaucratic hurdles can make it feel even harder to get Nayzilam. Learn more about saving money on Nayzilam.
Don't wait until your current supply runs out to request a refill. Talk to your neurologist about writing your prescription early so you have time to navigate any availability or insurance issues.
Tools like MedFinder can help you locate pharmacies that currently have Nayzilam in stock near you. This saves you the time and stress of calling around to multiple pharmacies. Check out our guide on how to find Nayzilam in stock near you.
Your doctor's office or insurance company may be able to direct you to a specialty pharmacy that regularly stocks Nayzilam. These pharmacies often have more reliable supply chains for niche medications.
If Nayzilam is truly unavailable, talk to your doctor about temporary alternatives like Valtoco (Diazepam nasal spray) or Diastat. While these aren't identical to Nayzilam, they are other benzodiazepine rescue medications that may work for seizure clusters.
UCB Pharma offers a savings card for commercially insured patients through nayzilam.com/savings. If you're uninsured or underinsured, UCBCares may also be able to help.
The supply situation can change from month to month. For the latest updates, read our Nayzilam shortage update for 2026. You can also check the FDA Drug Shortage Database and the ASHP Drug Shortage Resource Center for official updates.
Nayzilam is hard to find in 2026 primarily because it has a single manufacturer, no generic version, and faces the same supply chain pressures that affect many specialty medications. But there are steps you can take — from planning ahead to using pharmacy finder tools like MedFinder — to improve your chances of getting this important seizure rescue medication when you need it.
If you're a healthcare provider looking for resources to help your patients, visit our provider's guide to the Nayzilam shortage.
You focus on staying healthy. We'll handle the rest.
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