Struggling to find Myfembree at your pharmacy? Learn why this uterine fibroid and endometriosis medication is hard to find and what you can do about it.
If you've been prescribed Myfembree (Relugolix/Estradiol/Norethindrone Acetate) for uterine fibroids or endometriosis pain, you may have already experienced the frustration of showing up at a pharmacy only to be told it's not in stock. You're not alone — many patients across the U.S. are running into the same problem in 2026.
In this article, we'll explain exactly what Myfembree is, why it can be so difficult to find, and what steps you can take to get your prescription filled.
Myfembree is a once-daily prescription tablet that combines three active ingredients: Relugolix (a GnRH receptor antagonist), Estradiol, and Norethindrone Acetate. It was approved by the FDA in May 2021 and is manufactured by Myovant Sciences in collaboration with Pfizer.
Myfembree is prescribed for premenopausal women to manage:
It works by suppressing the hormones that fuel fibroid growth and endometriosis symptoms, while the estradiol and norethindrone acetate components provide "add-back" therapy to protect bone health and reduce hot flashes.
Myfembree is not a common everyday medication like blood pressure pills or antibiotics. It's a specialty drug used by a relatively small number of patients. Because of this, many retail pharmacies — especially large chains like CVS, Walgreens, and Rite Aid — don't keep it regularly in stock. The drug costs over $1,500 per month at retail price, which makes pharmacies less likely to stock it without a confirmed prescription.
Most insurance plans require prior authorization before they'll cover Myfembree. Some plans also require step therapy, meaning you may need to try and fail on other treatments first. These administrative hurdles can delay your prescription by days or even weeks, and pharmacies may not order the drug until insurance approval is confirmed.
If you're dealing with insurance issues, our guide on how to save money on Myfembree covers copay assistance programs and other cost-saving options.
At a retail price of roughly $1,200 to $1,700 per month, Myfembree is an expensive medication. Pharmacies must invest significant capital to keep it on their shelves, and if they don't have regular demand for it, they may choose not to stock it at all. This is a common issue with brand-name specialty medications.
While a generic version of Myfembree (Relugolix/Estradiol/Norethindrone Acetate) has become available, distribution of the generic is still ramping up. Not all pharmacies carry the generic version yet, which can contribute to availability challenges. The generic may be priced around $1,150 per month with a discount coupon — still a significant cost for pharmacies to stock.
If your local pharmacy doesn't have Myfembree in stock, here are some practical steps you can take:
Medfinder lets you search for pharmacies that currently have Myfembree in stock near your location. Instead of calling pharmacy after pharmacy, you can check availability online in seconds.
Independent pharmacies and specialty pharmacies are often more willing to order medications like Myfembree and may already carry it for existing patients. Specialty pharmacies in particular are set up to handle high-cost medications and may offer additional support services.
Your prescribing OB/GYN or reproductive endocrinologist may have relationships with specialty pharmacies that regularly stock Myfembree. Ask your provider's office for a recommendation.
Because Myfembree may not be immediately available, try to request refills at least a week before your current supply runs out. This gives the pharmacy time to order it if needed.
For more detailed tips, see our full guide on how to find Myfembree in stock near you.
Finding Myfembree can be frustrating, but it's not impossible. The main reasons it's hard to find — limited stocking at retail pharmacies, insurance hurdles, and high cost — are common challenges with specialty medications. By using tools like Medfinder, exploring specialty pharmacies, and working closely with your healthcare provider, you can improve your chances of getting your prescription filled without unnecessary delays.
If Myfembree is truly unavailable in your area, talk to your doctor about alternative medications that may be able to help manage your symptoms while you work on getting your Myfembree prescription filled.
You focus on staying healthy. We'll handle the rest.
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