Find out why Claravis (Isotretinoin) is so hard to find in 2026, what's causing supply issues, and what you can do to get your prescription filled.
You've been through the blood tests, the pregnancy screenings, and the iPLEDGE paperwork. Your dermatologist finally prescribed Claravis for your severe acne — and now the pharmacy tells you it's out of stock. Sound familiar?
Claravis (generic Isotretinoin) has become increasingly difficult to find at pharmacies across the United States. Whether you're starting a new course of treatment or mid-cycle, running into supply problems is frustrating and stressful. In this article, we'll explain exactly why Claravis is so hard to find in 2026 and what steps you can take right now.
Claravis is a brand of Isotretinoin, a powerful retinoid (Vitamin A derivative) used to treat severe nodular acne that hasn't responded to other treatments like antibiotics or topical retinoids. It works by dramatically reducing oil production in the skin, shrinking sebaceous glands, and reducing acne-causing bacteria.
Isotretinoin is one of the most effective acne treatments available, but it comes with significant safety requirements. Because it causes severe birth defects, all patients, prescribers, and pharmacies must be registered in the iPLEDGE REMS program before the medication can be dispensed.
Other brand names for Isotretinoin include Absorica, Amnesteem, Myorisan, and Zenatane. The original brand, Accutane, was discontinued by Roche in 2009.
There are several reasons why you might be having trouble finding Claravis at your local pharmacy in 2026:
Claravis is manufactured by Teva Pharmaceuticals, one of the world's largest generic drug makers. Like many generic manufacturers, Teva has experienced intermittent production issues affecting certain dosage strengths. When a manufacturer can't keep up with demand — whether due to raw material shortages, production line maintenance, or regulatory inspections — pharmacies run out of stock quickly.
The iPLEDGE REMS program is a mandatory federal safety program that governs how Isotretinoin is prescribed and dispensed. Patients must complete monthly check-ins, pregnancy tests (for females of childbearing potential), and pick up their prescription within a strict 7-day dispensing window.
This system — while critical for safety — creates logistical challenges. If a pharmacy doesn't have your specific strength in stock when your window opens, you may not be able to simply try another pharmacy without additional coordination. The iPLEDGE system overhaul in late 2021 caused widespread dispensing delays, and lingering issues with the platform have continued to affect patients.
Not every pharmacy stocks Isotretinoin routinely. Because the drug requires iPLEDGE registration and has a narrow dispensing window, many smaller pharmacies choose not to carry it. Even large chains may only stock it at certain locations, which limits your options when your regular pharmacy is out.
Isotretinoin prescriptions have increased in recent years as more patients and dermatologists turn to the drug for moderate-to-severe acne that doesn't respond to other treatments. With demand outpacing production at times, certain strengths — particularly the 20 mg and 40 mg capsules — can be harder to find.
If you're struggling to fill your Claravis prescription, here are practical steps you can take:
Instead of calling pharmacy after pharmacy, use Medfinder to search for Claravis availability near you in real time. It's free and can save you hours of phone calls.
Claravis is just one brand of Isotretinoin. Your doctor or pharmacist may be able to switch you to Amnesteem, Myorisan, Zenatane, or Absorica if Claravis specifically is unavailable. All contain the same active ingredient. Learn more about your options in our alternatives guide.
Independent pharmacies often have more flexibility in ordering from different wholesalers and may be able to source Isotretinoin more quickly than chain pharmacies. Read our tips for finding Claravis in stock.
If you're running low, don't wait until the last minute. Contact your dermatologist's office as soon as you anticipate a supply problem. They may be able to adjust your dosage to a strength that's more readily available, or coordinate directly with a pharmacy that has stock.
Since you only have a 7-day window to pick up your prescription after your iPLEDGE confirmation, ask your pharmacy to check stock before your window opens. If they don't have it, you'll have time to find a pharmacy that does.
Finding Claravis shouldn't be this hard — but in 2026, supply chain issues, iPLEDGE logistics, and uneven pharmacy stocking make it a real challenge for many patients. The good news is that tools like Medfinder and communication with your healthcare team can help you stay on track with your treatment.
For more information, check out our guides on the latest Claravis shortage updates and how to save money on Claravis.
You focus on staying healthy. We'll handle the rest.
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