Lisdexamfetamine (Vyvanse) is a stimulant used for ADHD and Binge Eating Disorder. Learn about uses, dosage, cost, side effects, and what's new in 2026.
Lisdexamfetamine Dimesylate is a long-acting CNS stimulant medication best known by the brand name Vyvanse. It is FDA-approved to treat Attention Deficit Hyperactivity Disorder (ADHD) in patients aged 6 and older and moderate to severe Binge Eating Disorder (BED) in adults.
This guide covers everything you need to know about Lisdexamfetamine in 2026 — from how it works to what it costs and how to get it.
Lisdexamfetamine is a prodrug, meaning it's inactive until your body converts it into its active form — Dextroamphetamine (d-Amphetamine). This conversion happens after you swallow the medication, which gives it a smoother onset and longer duration compared to immediate-release stimulants.
Key facts about Lisdexamfetamine:
For a detailed explanation of how the medication works in your body, see our mechanism of action guide.
Lisdexamfetamine is one of the most commonly prescribed medications for ADHD. It helps improve attention, focus, and impulse control by increasing levels of dopamine and norepinephrine in the brain. It's approved for both children (6+) and adults.
Lisdexamfetamine is the first and only FDA-approved medication for moderate to severe BED in adults. It helps reduce the number of binge eating days per week. It is not approved for weight loss.
Some doctors prescribe Lisdexamfetamine off-label for treatment-resistant depression (as an augmentation strategy) and excessive daytime sleepiness, though these uses are not FDA-approved.
Lisdexamfetamine comes in two forms:
Dosing guidelines:
Your doctor will typically start at 30 mg and increase the dose in 10–20 mg increments at weekly intervals until the right balance of effectiveness and side effects is found.
Lisdexamfetamine is not safe for everyone. You should not take it if you have:
Tell your doctor about all your medical conditions and medications before starting Lisdexamfetamine, including any potential drug interactions.
The most frequently reported side effects include:
For a complete breakdown of side effects and when to seek medical attention, read our side effects guide.
Cost varies widely depending on whether you use insurance, coupons, or pay cash:
Some insurance plans require step therapy — meaning you may need to try Methylphenidate (Concerta, Ritalin) before they'll cover Lisdexamfetamine. If cost is a concern, our complete savings guide covers every option available.
Lisdexamfetamine is a well-established, effective medication for ADHD and Binge Eating Disorder. With generics now widely available, it's more accessible and affordable than ever — though the ongoing shortage can still make it hard to find.
If you need help locating Lisdexamfetamine at a pharmacy near you, try Medfinder to check real-time stock. And if you're looking for a prescriber, our guide to finding a doctor can help.
You focus on staying healthy. We'll handle the rest.
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