What Is Ebglyss?

Ebglyss (lebrikizumab-lbkz) is a prescription biologic medication used to treat moderate-to-severe atopic dermatitis (eczema) in adults and adolescents aged 12 and older who weigh at least 40 kg (88 lb). It's made by Eli Lilly and was approved by the FDA in September 2024. Ebglyss works by blocking interleukin-13 (IL-13), a key protein that causes the inflammation, itching, and skin barrier damage behind eczema flares.

What Is Ebglyss Used For?

Ebglyss is FDA-approved for one indication:

• Moderate-to-severe atopic dermatitis in adults and adolescents (12+) weighing at least 40 kg, who are candidates for systemic therapy.

"Candidates for systemic therapy" typically means people whose eczema hasn't responded well enough to topical treatments like steroid creams or calcineurin inhibitors. Ebglyss is not a first-line treatment — it's reserved for cases where other options haven't provided enough relief.

Ebglyss was also studied for asthma in clinical trials, but it is not FDA-approved for asthma.

How Is Ebglyss Taken?

Ebglyss is a subcutaneous injection (under the skin) using a prefilled syringe or prefilled pen. Here's the dosing schedule:

• Loading doses: 500 mg (two 250 mg injections) at Week 0 and again at Week 2.
• Early maintenance: 250 mg every 2 weeks from Week 2 through Week 16.
• Long-term maintenance: 250 mg every 4 weeks after Week 16.

You can inject into your thigh, abdomen (avoiding the navel area), or upper arm (if someone else gives the injection). Rotate injection sites each time.

Preparation tips:

• Let the prefilled syringe or pen reach room temperature for about 45 minutes before injecting.
• Don't shake the medication.
• The solution should look clear and colorless to pale yellow or brown.

After initial training from your healthcare provider, most patients self-inject at home. For more on how the drug works in your body, see our mechanism of action guide.

Who Should Not Take Ebglyss?

Ebglyss should not be used if you have a known hypersensitivity (allergy) to lebrikizumab-lbkz or any of its inactive ingredients.

Additionally, you should talk to your doctor before starting Ebglyss if you:

• Are pregnant or planning to become pregnant
• Are breastfeeding
• Have a parasitic (helminth) infection — it should be treated before starting Ebglyss
• Need live vaccines — avoid live vaccines during treatment; get vaccinations up to date before starting
• Have current eye problems, especially conjunctivitis or keratitis

There is no boxed warning for Ebglyss. For a full breakdown of side effects, read our Ebglyss side effects guide.

How Much Does Ebglyss Cost?

Without insurance, Ebglyss costs approximately $2,500 to $3,800 per injection, or roughly $3,200 per month during maintenance dosing. There is no generic or biosimilar version available — Ebglyss is under patent protection.

However, most patients don't pay the full price:

• Insurance: Most commercial plans and Medicare Part D cover Ebglyss, usually with prior authorization and step therapy requirements.
• Eli Lilly Savings Card: Commercially insured patients may pay as little as $0 per injection. Enroll at ebglyss.com or call 1-800-545-6962.
• Lilly Cares Foundation: Uninsured or underinsured patients may qualify for free medication through this patient assistance program. Apply at lillycares.com.

For more ways to reduce your costs, see our guide to saving money on Ebglyss.

Final Thoughts

Ebglyss is a targeted biologic that offers a newer option for people living with moderate-to-severe eczema. It specifically blocks IL-13, is self-injectable at home, and moves to a convenient every-4-weeks schedule after the initial loading period. If you think Ebglyss might be right for you, talk to your dermatologist or allergist.

Search for Ebglyss availability at medfinder.com.