Learn about Ebglyss drug interactions, including live vaccines, immunosuppressants, and CYP450 medications. Know what to tell your doctor before starting.
Before starting any new medication, it's important to understand how it might interact with other drugs, supplements, or even foods. If you've been prescribed Ebglyss (lebrikizumab-lbkz) for moderate-to-severe atopic dermatitis, here's what you need to know about potential interactions.
The good news: as a monoclonal antibody, Ebglyss has a relatively clean interaction profile compared to many other medications. But there are still some important things to watch for.
Unlike traditional medications that are processed through your liver (via cytochrome P450 enzymes), monoclonal antibodies like Ebglyss are broken down by the body's natural protein recycling processes. This means Ebglyss is not expected to directly interact with most medications through typical drug metabolism pathways.
No formal drug interaction studies have been conducted for Ebglyss. However, there are still situations where caution is warranted.
This is the most important interaction to know about. You should not receive live vaccines while taking Ebglyss. Since Ebglyss affects part of your immune system, live vaccines may not work as well or could potentially cause infection.
Examples of live vaccines include:
Make sure all your vaccinations are up to date before starting Ebglyss. Inactivated vaccines (like the flu shot or COVID-19 vaccines) are generally fine to receive during treatment.
If you're taking other medications that suppress your immune system — such as oral corticosteroids, cyclosporine, methotrexate, or other biologics — there's a theoretical risk of additive immunosuppression when combined with Ebglyss. Your doctor will evaluate whether combining these medications is appropriate for your situation.
This one is subtle but worth mentioning. In conditions with significant inflammation (like severe eczema), certain liver enzymes (CYP450) can be suppressed. When Ebglyss reduces that inflammation, those enzymes may return to normal activity — which could change how your body processes certain medications.
Drugs with a narrow therapeutic index that could be affected include:
If you take any of these, your doctor may want to monitor your levels more closely after starting Ebglyss.
There are no known interactions between Ebglyss and common supplements or OTC medications. However, it's always a good idea to tell your doctor about everything you take, including:
Topical corticosteroids and moisturizers can generally be used alongside Ebglyss without issue.
There are no known food or drink interactions with Ebglyss. You don't need to avoid any foods or change your diet while taking this medication.
Before your first injection, make sure your doctor knows about:
For more on what to expect from treatment, see our guides on Ebglyss side effects and Ebglyss uses and dosage.
Ebglyss has a relatively low risk of drug interactions compared to many other medications. The main things to watch are live vaccines (avoid them), other immunosuppressants (use with caution), and narrow therapeutic index drugs (may need monitoring). As always, keep your healthcare team informed about everything you're taking.
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