Compro Is a Prescription Antiemetic Used to Treat Severe Nausea and Vomiting

Compro (Prochlorperazine) is a prescription medication in the phenothiazine drug class that works by blocking dopamine receptors in the brain to control severe nausea and vomiting in adults.

If your doctor has prescribed Compro — or you're researching it before an appointment — this guide covers everything you need to know: what it's used for, how to take it, who should avoid it, and what it costs in 2026.

What Is Compro?

Here are the key facts:

• Brand name: Compro
• Generic name: Prochlorperazine
• Drug class: Phenothiazine (first-generation antipsychotic / antiemetic)
• Manufacturer: Padagis US LLC
• Controlled substance: No — Compro is not a controlled substance
• Generic available: Yes — generic Prochlorperazine is widely available

Compro specifically refers to the 25 mg rectal suppository formulation. Prochlorperazine is also available as oral tablets (5 mg and 10 mg) and an injectable solution (5 mg/mL), though these are sold under the generic name since the original brand Compazine was discontinued.

Other names you might see: Prochlorperazine Maleate (tablets), Prochlorperazine Edisylate (injection).

What Is Compro Used For?

FDA-Approved Uses

• Severe nausea and vomiting in adults — This is the primary FDA-approved use for the Compro suppository. It's particularly useful when a patient can't keep oral medications down.
• Schizophrenia and psychotic disorders — Oral and injectable Prochlorperazine are approved for managing psychotic symptoms (not the suppository form).
• Non-psychotic anxiety — Short-term use only, for the oral formulation.

Common Off-Label Uses

• Migraine headaches — Prochlorperazine is a first-line treatment for migraines in emergency departments, per the American Headache Society. It's effective for both the headache and the nausea that often accompanies migraines.
• Chemotherapy-induced nausea and vomiting (CINV) — Used as part of antiemetic regimens for cancer patients.
• Post-operative nausea and vomiting — Sometimes used in surgical settings.

How Is Compro Taken?

The specific formulation determines how you take it:

Compro Suppository (25 mg)

• Insert one 25 mg suppository rectally
• Use every 12 hours as needed for severe nausea and vomiting
• Wash hands before and after insertion
• Lie on your side with one knee bent for easier insertion
• Stay lying down for a few minutes after insertion to prevent the suppository from coming out

Oral Prochlorperazine Tablets (5 mg, 10 mg)

• Take 5–10 mg every 6–8 hours as directed
• Maximum dose: 40 mg per day for nausea
• Swallow with water — do not crush
• Can be taken with or without food

Injectable (5 mg/mL)

• Given by a healthcare professional via intramuscular (IM) or intravenous (IV) injection
• Dose: 5–10 mg every 3–4 hours as needed
• Typically used in hospital or clinic settings

Your doctor will determine the right formulation and dose based on your condition and how severe your symptoms are.

Who Should Not Take Compro?

Compro is not safe for everyone. You should not take it if you have:

• A known allergy to Prochlorperazine or other phenothiazines
• Comatose states or severely depressed consciousness
• Concurrent use of large amounts of CNS depressants (alcohol, barbiturates, narcotics)
• Narrow-angle glaucoma
• Prostatic hypertrophy (enlarged prostate)
• Pre-existing cardiac conduction abnormalities
• History of seizures or epilepsy (Prochlorperazine lowers the seizure threshold)
• Current or past tardive dyskinesia

Compro is contraindicated in children under 2 years old or under 20 pounds and should not be used for pediatric surgery.

For information about drug interactions and side effects, see our dedicated guides.

How Much Does Compro Cost?

The cost of Prochlorperazine varies significantly depending on the formulation:

Compro Suppositories (25 mg, 12 count)

• Cash price: $80–$175
• With coupon (GoodRx/SingleCare): $27–$80

Oral Prochlorperazine Tablets (10 mg, 30 count)

• Cash price: $15–$50
• With coupon: As low as $3–$16

Insurance Coverage

Generic Prochlorperazine is widely covered on most commercial, Medicaid, and Medicare Part D formularies. It's usually placed on Tier 1 (lowest copay tier), and prior authorization is typically not required for oral or rectal formulations.

Saving Money

There is no active manufacturer savings program for Compro, since the drug is available generically. However, you can save significantly with:

• Discount cards from GoodRx, SingleCare, and RxSaver
• Patient assistance through NeedyMeds and RxAssist
• State pharmaceutical assistance programs

See our complete Compro savings guide for all your options.

Final Thoughts

Compro is a well-established medication that's been used for decades to treat severe nausea and vomiting. The suppository form is especially valuable for patients who can't keep oral medications down. It's available generically, covered by most insurance plans, and affordable with discount cards.

Before starting Compro, make sure your doctor knows about all your other medications, medical conditions, and any history of movement disorders, seizures, or heart problems. For a deeper dive into how Compro works or how to find a prescribing doctor, check out our other guides.

Need help finding Compro in stock? Medfinder can help you locate a pharmacy near you.