What Is Breyna? Uses, Dosage, and What You Need to Know in 2026

Updated:

March 28, 2026

Author:

Peter Daggett

Summarize this blog with AI:

Breyna is a generic inhaler for asthma and COPD. Learn what it is, how to use it, approved dosages, who shouldn't take it, and how much it costs in 2026.

Breyna Is a Generic Combination Inhaler for Asthma and COPD

Breyna is an FDA-approved prescription inhaler that combines Budesonide (an inhaled corticosteroid) and Formoterol Fumarate Dihydrate (a long-acting beta-agonist) to help people with asthma and COPD breathe easier.

If your doctor has prescribed Breyna — or you've seen it mentioned as a more affordable alternative to Symbicort — this guide covers everything you need to know: what it is, what it treats, how to take it, who should avoid it, and what it costs.

What Is Breyna?

Breyna is the first FDA-approved generic version of Symbicort, manufactured by Viatris in partnership with Kindeva Drug Delivery. It was approved and launched in July 2023.

Here are the basics:

  • Brand name: Breyna
  • Generic name: Budesonide and Formoterol Fumarate Dihydrate
  • Reference brand: Symbicort (AstraZeneca)
  • Drug class: Inhaled Corticosteroid / Long-Acting Beta-2 Agonist (ICS/LABA)
  • Manufacturer: Viatris
  • Controlled substance: No — Breyna is not a controlled substance and has no DEA schedule
  • Available strengths: 80/4.5 mcg and 160/4.5 mcg per actuation
  • Form: Metered-dose inhaler (MDI) with 120 inhalations per canister

Breyna contains the exact same active ingredients in the same doses as Symbicort. It was approved through the FDA's abbreviated pathway for generic drugs, meaning it met rigorous standards for bioequivalence.

What Is Breyna Used For?

Breyna is FDA-approved for three indications:

  1. Maintenance treatment of asthma in patients 6 years of age and older who require both an inhaled corticosteroid and a long-acting beta-agonist
  2. Maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema
  3. Reducing COPD exacerbations in patients with a history of exacerbations

Important: Breyna is a maintenance inhaler. It's meant to be used every day to prevent symptoms — not as a rescue inhaler for sudden breathing problems. You should always keep a separate short-acting inhaler (like Albuterol) available for emergencies.

For a detailed explanation of how Breyna works in your body, see our mechanism of action guide.

How Is Breyna Taken?

Breyna is taken as 2 inhalations twice daily — once in the morning and once in the evening, about 12 hours apart. This applies to both asthma and COPD.

Available Strengths

  • Breyna 80/4.5 mcg — lower strength, typically used for asthma in adults with milder disease or in children ages 6 and older
  • Breyna 160/4.5 mcg — higher strength, commonly prescribed for adults with moderate-to-severe asthma or COPD

How to Use Your Inhaler

  1. Shake well before each use (at least 5 seconds)
  2. Prime the inhaler before first use by releasing 2 test sprays into the air, away from your face. Also prime if you haven't used it in more than 7 days.
  3. Breathe out fully, then place the mouthpiece in your mouth
  4. Breathe in slowly and deeply while pressing down on the canister
  5. Hold your breath for about 10 seconds, then breathe out slowly
  6. Wait at least 30 seconds before taking the second inhalation
  7. Rinse your mouth with water after each use and spit it out — this helps prevent oral thrush

Do not exceed the prescribed dose. Do not use Breyna more than twice daily.

Who Should Not Take Breyna?

Breyna is not appropriate for everyone. You should not use Breyna if you have:

  • Status asthmaticus or an acute asthma attack — Breyna is not a rescue medication and should not be used for sudden, severe breathing problems
  • Severe hypersensitivity to milk proteins — the formulation contains trace amounts of milk proteins, which can cause allergic reactions in sensitive individuals
  • Known allergy to Budesonide, Formoterol, or any inactive ingredients in the inhaler

Use With Caution

Talk to your doctor before using Breyna if you have:

  • Heart disease, arrhythmias, or high blood pressure
  • Seizure disorders
  • Thyroid disorders
  • Diabetes (Formoterol can raise blood sugar)
  • Osteoporosis (long-term inhaled corticosteroids may affect bone density)
  • Liver disease
  • Active or quiescent tuberculosis
  • Any untreated fungal, bacterial, or viral infections

Breyna is Pregnancy Category C — use only if the benefits outweigh the risks. Budesonide passes into breast milk, so breastfeeding mothers should discuss options with their doctor.

Drug Interactions

Breyna can interact with other medications. Major interactions include:

  • MAO inhibitors — avoid use within 14 days
  • Beta-blockers — can block the bronchodilatory effects of Formoterol
  • Strong CYP3A4 inhibitors (Ketoconazole, Ritonavir, Clarithromycin) — can increase Budesonide levels in your body
  • Other long-acting beta-agonists — do not combine with Breyna

For the full list, see our detailed guide to Breyna drug interactions.

How Much Does Breyna Cost?

As a generic, Breyna is less expensive than brand-name Symbicort, but it's not cheap:

  • Without insurance: $280 to $472 per inhaler, depending on strength and pharmacy
  • With a discount card (GoodRx, SingleCare): approximately $155 to $280
  • With the Viatris Savings Card: as low as $20/month for commercially insured patients
  • With insurance: typically covered on a preferred generic tier; copays vary by plan

If cost is a barrier, there are several ways to save. The Viatris Patient Assistance Program provides Breyna for free to qualifying uninsured patients. Discount cards, manufacturer savings programs, and shopping around can all make a big difference. See our complete guide to saving money on Breyna.

How Does Breyna Compare to Symbicort?

Breyna and Symbicort contain the same active ingredients at the same strengths. They're therapeutically equivalent — meaning the FDA considers them interchangeable. The main differences:

  • Price: Breyna is generally less expensive, especially with discount cards
  • Manufacturer: Symbicort is made by AstraZeneca; Breyna by Viatris
  • Inhaler device: Both are metered-dose inhalers, but the feel, taste, or spray force may differ slightly

If you've been using Symbicort successfully, switching to Breyna should be seamless. If you notice any difference in how it feels or works, talk to your doctor.

Final Thoughts

Breyna is a well-established, FDA-approved generic inhaler that makes Budesonide/Formoterol more accessible and affordable. Whether you have asthma, COPD, or both, it's a proven option for daily maintenance therapy that keeps your airways open and inflammation down.

If you need help finding Breyna at a pharmacy near you, Medfinder can help you check stock without calling around. And if you're looking for a prescribing doctor, check out our guide to finding a Breyna provider.

Is Breyna the same as Symbicort?

Breyna contains the same active ingredients (Budesonide and Formoterol Fumarate Dihydrate) at the same strengths as Symbicort. It's the first FDA-approved generic version of Symbicort and is considered therapeutically equivalent. The main difference is price — Breyna is typically less expensive.

Can Breyna be used as a rescue inhaler?

No. Breyna is a maintenance inhaler meant to be used every day to prevent asthma and COPD symptoms. It should not be used for sudden breathing problems or acute asthma attacks. You should always keep a separate rescue inhaler, like Albuterol, available for emergencies.

What ages can use Breyna?

Breyna is approved for patients 6 years of age and older for asthma treatment. Children ages 6 and older should use the 80/4.5 mcg strength. It is not approved for children under 6. For COPD, it is used in adults.

How much does Breyna cost without insurance in 2026?

Without insurance, Breyna costs approximately $280 to $472 per inhaler depending on the strength and pharmacy. Prescription discount cards like GoodRx or SingleCare can bring the price down to about $155 to $280. The Viatris Savings Card can reduce the cost to as low as $20 per month for commercially insured patients.

Why waste time calling, coordinating, and hunting?

You focus on staying healthy. We'll handle the rest.

Try Medfinder Concierge Free

Medfinder's mission is to ensure every patient gets access to the medications they need. We believe this begins with trustworthy information. Our core values guide everything we do, including the standards that shape the accuracy, transparency, and quality of our content. We’re committed to delivering information that’s evidence-based, regularly updated, and easy to understand. For more details on our editorial process, see here.

25,000+ have already found their meds with Medfinder.

Start your search today.
      What med are you looking for?
⊙  Find Your Meds
99% success rate
Fast-turnaround time
Never call another pharmacy