Brexafemme Kit Is an Oral Antifungal Medication Used to Treat and Prevent Vaginal Yeast Infections

Brexafemme Kit (Ibrexafungerp) is a prescription oral antifungal that treats acute vulvovaginal candidiasis (VVC) and helps prevent recurrent vulvovaginal candidiasis (RVVC) in adult and postmenarchal pediatric females.

If you've been prescribed Brexafemme Kit — or you're researching it because other yeast infection treatments haven't worked — this guide covers everything you need to know: what it is, how to take it, who should and shouldn't use it, and what it costs in 2026.

What Is Brexafemme Kit?

Here are the key facts:

• Brand name: Brexafemme Kit (also marketed as Brexafemme)
• Generic name: Ibrexafungerp
• Drug class: Triterpenoid antifungal (glucan synthase inhibitor)
• Manufacturer: Originally developed by Scynexis, Inc. The NDA was transferred to GSK in November 2025.
• FDA approval: Approved June 1, 2021 for acute VVC; expanded approval November 30, 2022 for RVVC prevention
• Controlled substance: No — Brexafemme Kit is not a controlled substance
• Dosage form: 150 mg film-coated oral tablets

Brexafemme Kit represents a first-in-class medication. It's the first oral triterpenoid antifungal — a completely new type of antifungal that works differently from older drugs like Fluconazole (Diflucan). For a plain-English explanation of how it works, see our guide on Brexafemme Kit's mechanism of action.

What Is Brexafemme Kit Used For?

Brexafemme Kit has two FDA-approved uses:

1. Treating Acute Vaginal Yeast Infections (VVC)

Vulvovaginal candidiasis — a vaginal yeast infection — is extremely common. About 75% of women will experience at least one yeast infection in their lifetime. Most are caused by Candida albicans fungus.

Brexafemme Kit treats acute episodes when they occur. It's especially useful for women who:

• Haven't responded well to Fluconazole
• Can't tolerate azole antifungals
• Have infections caused by resistant Candida strains

2. Preventing Recurrent Yeast Infections (RVVC)

Recurrent vulvovaginal candidiasis is defined as three or more episodes within a year. RVVC affects about 5-8% of women and can significantly impact quality of life. Brexafemme Kit can be taken monthly to reduce the number of episodes over a six-month period.

How Is Brexafemme Kit Taken?

For Acute VVC (One-Day Treatment)

1. Take two 150 mg tablets (300 mg) in the morning
2. Take two more 150 mg tablets (300 mg) approximately 12 hours later in the evening
3. Total dose: 600 mg in one day

That's it — the entire treatment is completed in a single day. You can take the tablets with or without food.

For RVVC Prevention (Monthly Dosing)

1. Take two 150 mg tablets (300 mg) in the morning
2. Take two more 150 mg tablets (300 mg) approximately 12 hours later
3. Repeat this one-day dosing once per month for 6 months

Dose Adjustment

If you're taking a strong CYP3A4 inhibitor (such as Ketoconazole, Itraconazole, Clarithromycin, or Ritonavir), your dose is reduced to one 150 mg tablet twice, 12 hours apart (300 mg total instead of 600 mg). Check our drug interactions guide for the full list.

Who Should Not Take Brexafemme Kit?

Brexafemme Kit is not safe for everyone. You should not take it if:

• You are pregnant or might be pregnant. Brexafemme Kit is contraindicated in pregnancy due to potential fetal harm shown in animal studies. A pregnancy test is recommended before starting treatment.
• You have a known allergy to Ibrexafungerp or any ingredients in the tablets.
• You have severe liver disease (Child-Pugh C). Mild to moderate liver impairment does not require dose changes, but severe impairment is a contraindication.

Tell your doctor about all your medical conditions, especially if you are breastfeeding (not recommended unless benefits outweigh risks), have liver or kidney problems, or are taking any other medications.

For more on safety, read our side effects guide.

Common Side Effects

The most common side effects reported in clinical trials:

• Diarrhea (16.7%)
• Nausea (11.9%)
• Abdominal pain (11.4%)
• Dizziness (3.3%)
• Vomiting (2.0%)

Most side effects are mild and resolve within a day or two. For detailed management tips, see our complete side effects guide.

How Much Does Brexafemme Kit Cost?

Brexafemme Kit is a brand-name medication with no generic available as of 2026.

• Cash price (without insurance): $450–$600 per treatment course
• With insurance: Many commercial plans and some Medicare Part D plans cover Brexafemme Kit, but often require prior authorization or step therapy (trying Fluconazole first)
• Copay assistance: Scynexis previously offered a savings card that could reduce copays to as low as $30 for commercially insured patients. Call 1-844-431-9894 to check current availability.
• Patient assistance: Uninsured or underinsured patients may qualify for assistance through GSK's programs (GSK For You) following the NDA transfer
• Medicare Part D: With the $2,000 annual out-of-pocket cap, yearly medication costs are limited

For a detailed breakdown of savings options, see our guide to saving money on Brexafemme Kit.

Current Availability

As of early 2026, Brexafemme Kit is temporarily unavailable. Scynexis transferred the NDA to GSK in November 2025, and there is no confirmed date for when the product will return to market. For the latest updates, check our shortage update and use Medfinder to monitor pharmacy availability.

How Does Brexafemme Kit Compare to Alternatives?

Here's how Brexafemme Kit stacks up against other yeast infection treatments:

• Fluconazole (Diflucan): Single oral dose, generic, very affordable ($3–$15). First-line treatment for most yeast infections. Many insurance plans require trying it before covering Brexafemme Kit.
• Oteseconazole (Vivjoa): Newer oral antifungal approved for RVVC prevention. Also contraindicated in pregnancy. Brand-name only.
• Miconazole (Monistat): OTC topical cream/suppository. Available in 1-day, 3-day, and 7-day regimens. $10–$20.
• Clotrimazole: OTC topical antifungal cream. Available in various regimens. $8–$15.

See our full alternatives guide for a detailed comparison.

Final Thoughts

Brexafemme Kit represents an important advancement in treating vaginal yeast infections — it's the first oral antifungal in a brand-new drug class, offering a one-day treatment option for acute VVC and monthly prevention for recurrent infections. Its unique mechanism of action makes it a valuable option for women who haven't found success with traditional treatments like Fluconazole.

The main challenges right now are cost and availability. Without insurance, treatment runs $450–$600, and the medication is temporarily unavailable as of early 2026. Work with your healthcare provider to determine if Brexafemme Kit is right for you, and check Medfinder regularly for availability updates.