How to Save Money on Rexulti in 2026: Coupons, Discounts, and Patient Assistance

Rexulti (brexpiprazole) is an effective medication for major depressive disorder, schizophrenia, and Alzheimer's-related agitation — but it's expensive. The list price is approximately $1,515 per month, and the average retail cash price can exceed $1,800 to $2,000 per month depending on the pharmacy and dosage strength.

The good news: most patients are not paying that full price. Here's a complete breakdown of every option available to reduce your cost of Rexulti in 2026 — whether you have commercial insurance, Medicare, Medicaid, or no insurance at all.

What does Rexulti actually cost?

Before exploring savings options, it helps to understand the pricing landscape:

• Cash price (no insurance): $1,527–$2,061 per 30-day supply, depending on the pharmacy and strength
• Commercial insurance average: According to Otsuka, commercially insured patients pay an average of $31 per month for Rexulti
• Medicare average: Medicare patients pay an average of approximately $21 per month, per Otsuka data (varies by plan and coverage phase)
• Without savings programs: Even with a GoodRx or SingleCare coupon, cash price remains $1,400–$1,500+ per month — discount cards have limited impact on expensive brand-name medications

Option 1: Rexulti Savings Card (for commercially insured patients)

This is the most impactful savings tool for patients with commercial (employer-sponsored or marketplace) insurance. The Rexulti Savings Card, offered by manufacturer Otsuka America Pharmaceutical, can reduce your out-of-pocket cost to as little as $0 per month, with an annual maximum benefit of $8,180.

The savings card covers copays, co-insurance, and pharmacy deductibles. It works for both monthly and 90-day supplies. Register at rexulti.com/savings-cost.

Who qualifies: Patients with commercial insurance that covers Rexulti. You must not be enrolled in Medicare, Medicaid, TRICARE, or other government insurance programs.

Restriction note: Residents of Massachusetts and California are not eligible if a generic alternative becomes available.

Option 2: Otsuka Patient Assistance Foundation (for uninsured/underinsured)

The Otsuka Patient Assistance Foundation (OPAF) is a nonprofit organization that provides Rexulti at no cost to eligible patients who are uninsured or underinsured and cannot afford their medication. This program is significantly underutilized — many qualifying patients never learn about it.

To apply, contact Otsuka Patient Support at 1-833-468-7852 or visit otsukapatientsupport.com/rexulti. Your prescriber will need to complete part of the application.

Option 3: Medicare Part D coverage

Most Medicare Part D plans cover Rexulti, though it may be on a specialty tier requiring prior authorization. According to Otsuka, the average monthly out-of-pocket cost for Medicare patients is approximately $21 per month, depending on the plan and coverage phase.

In 2026, the Medicare Part D annual out-of-pocket cap of $2,100 provides important protection for patients on expensive medications like Rexulti. Once your total out-of-pocket drug costs reach $2,100 for the year, you pay nothing for the rest of the year.

For low-income Medicare patients, the Part D Extra Help (Low-Income Subsidy) program may provide additional assistance. Apply at ssa.gov or by calling Social Security at 1-800-772-1213.

Option 4: GoodRx, SingleCare, and other discount cards

Prescription discount cards like GoodRx and SingleCare can provide some savings on Rexulti, but their impact is limited on expensive brand-name drugs. With a SingleCare coupon, the price may come down to around $1,471 for 30 tablets. GoodRx shows similar prices. These are meaningful savings on paper, but still out of reach for most uninsured patients.

Where discount cards become much more useful: if and when generic brexpiprazole becomes commercially available, discount cards can reduce generic prices to a fraction of the brand cost. Keep an eye on Medfinder updates for when this changes.

Option 5: Mail order for a 90-day supply

Many insurance plans offer reduced copays for 90-day mail-order prescription supplies. If you have commercial insurance with Rexulti coverage, ask your insurance plan about their mail-order pharmacy (Express Scripts, CVS Caremark, OptumRx are common). You may pay a lower total for a 90-day supply than for three separate 30-day fills.

Option 6: Ask about a therapeutic alternative

If cost remains a barrier after exploring all of the above, it may be worth discussing with your prescriber whether a similar medication with better generic availability — like aripiprazole (Abilify generic) — might be appropriate. Generic aripiprazole costs as little as $5–$88 per month. See our guide to Rexulti alternatives for a full comparison. This is a medical decision and should always involve your healthcare provider.

Summary: Savings options by insurance status

• Commercial insurance: Rexulti Savings Card (as low as $0/month), 90-day mail order
• Medicare: Part D coverage (~$21/mo avg), 2026 $2,100 out-of-pocket cap, Part D Extra Help/LIS program
• Medicaid: Covered for nearly all enrollees after meeting step therapy requirements
• Uninsured: Otsuka Patient Assistance Foundation (no-cost medication for eligible patients), GoodRx/SingleCare coupons