Jornay PM Drug Interactions: What You Need to Know

Jornay PM (methylphenidate) can interact with other medications, supplements, and even certain foods. Some interactions are dangerous, others just require monitoring. This guide covers the major and moderate drug interactions you should be aware of — and what to tell your doctor before starting Jornay PM.

How Drug Interactions Work

A drug interaction happens when one substance changes how another substance works in your body. This can happen in several ways:

• One drug increases the effect of another — making side effects more likely or more severe.
• One drug decreases the effect of another — making a medication less effective.
• Two drugs affect the same body system — amplifying risks (like both raising blood pressure).

Methylphenidate, the active ingredient in Jornay PM, primarily affects dopamine and norepinephrine in the brain. Any other substance that affects these same neurotransmitters — or that impacts blood pressure, heart rate, or serotonin levels — has the potential to interact. For more on how Jornay PM works, see our mechanism of action guide.

Major Drug Interactions

These interactions can be dangerous or life-threatening. In most cases, these medications should not be used together with Jornay PM:

MAO Inhibitors (MAOIs)

This is the most critical interaction. Combining Jornay PM with an MAOI — or taking Jornay PM within 14 days of stopping an MAOI — can cause a hypertensive crisis (a sudden, dangerous spike in blood pressure that can lead to stroke or death).

MAOIs include:

• Phenelzine (Nardil)
• Tranylcypromine (Parnate)
• Isocarboxazid (Marplan)
• Selegiline (Emsam) — used for depression and Parkinson's disease
• Linezolid (Zyvox) — an antibiotic that also has MAOI activity
• Methylene blue — used in certain medical procedures

What to do: Never take Jornay PM with an MAOI. If you're switching medications, a 14-day washout period is required.

Halogenated Anesthetics

If you need surgery and will receive halogenated anesthetics (such as sevoflurane, desflurane, or isoflurane), there's a risk of sudden blood pressure increase during the procedure.

What to do: Tell your surgeon and anesthesiologist that you take Jornay PM. Your doctor may recommend stopping the medication before a scheduled surgery.

Antihypertensive Medications

Methylphenidate can raise blood pressure, which may reduce the effectiveness of blood pressure medications including:

• Lisinopril (Zestril, Prinivil)
• Amlodipine (Norvasc)
• Losartan (Cozaar)
• Metoprolol (Lopressor)
• Hydrochlorothiazide (HCTZ)

What to do: Your doctor may need to adjust your blood pressure medication dose. Regular blood pressure monitoring is important.

Moderate Drug Interactions

These interactions require monitoring but don't necessarily mean you can't take both medications. Your doctor will weigh the risks and benefits.

Anticoagulants (Blood Thinners)

Methylphenidate may increase blood levels of Warfarin (Coumadin), raising the risk of bleeding.

What to do: If you take Warfarin and start Jornay PM, your doctor should monitor your INR (a blood clotting test) more frequently and may adjust your Warfarin dose.

Anticonvulsants (Seizure Medications)

Methylphenidate may increase blood levels of certain anticonvulsants, including:

• Phenytoin (Dilantin)
• Phenobarbital

What to do: Your doctor may need to check blood levels of these medications more frequently and adjust doses accordingly.

Tricyclic Antidepressants (TCAs)

Methylphenidate may increase blood levels of tricyclic antidepressants, including:

• Amitriptyline (Elavil)
• Nortriptyline (Pamelor)
• Imipramine (Tofranil)
• Desipramine (Norpramin)

What to do: Your doctor should monitor for increased TCA side effects (dry mouth, constipation, drowsiness, rapid heartbeat) and may adjust the dose.

SSRIs and SNRIs

Combining Jornay PM with serotonergic antidepressants increases the risk of serotonin syndrome, a potentially serious condition. Common SSRIs and SNRIs include:

• Fluoxetine (Prozac)
• Sertraline (Zoloft)
• Escitalopram (Lexapro)
• Venlafaxine (Effexor)
• Duloxetine (Cymbalta)

Serotonin syndrome symptoms include agitation, confusion, rapid heartbeat, high body temperature, muscle rigidity, and tremors.

What to do: Many ADHD patients take an SSRI or SNRI alongside their stimulant — it's common but requires careful monitoring. Report any unusual symptoms to your doctor immediately.

Supplements and OTC Medications to Watch

Don't forget about over-the-counter products and supplements. These can interact with Jornay PM too:

• Decongestants (pseudoephedrine, phenylephrine) — Found in many cold and sinus medications, these also raise blood pressure and heart rate. Combined with Jornay PM, the cardiovascular effects may be amplified.
• Caffeine — Not a drug interaction per se, but caffeine is also a stimulant. Combining it with Jornay PM can increase jitteriness, anxiety, and heart rate. Moderate your intake.
• St. John's Wort — Has serotonergic properties and may increase the risk of serotonin syndrome when combined with methylphenidate.
• Melatonin — Generally considered safe to use with Jornay PM and is often recommended to help with stimulant-related sleep difficulties. Check with your doctor.

Food and Drink Interactions

• Alcohol — Avoid alcohol while taking Jornay PM. Alcohol may alter the delayed-release mechanism of the capsule, potentially causing the medication to release too quickly. It also impairs judgment and can worsen side effects.
• Food — No significant food interactions. Jornay PM can be taken with or without food. However, taking it with a small snack in the evening may reduce nausea. If you're opening the capsule and sprinkling the beads on applesauce, consume it immediately — don't store it.

What to Tell Your Doctor

Before starting Jornay PM, give your doctor a complete list of:

• All prescription medications you currently take — especially antidepressants, blood pressure medications, blood thinners, and seizure medications.
• Over-the-counter medications — including cold and allergy medications, pain relievers, and sleep aids.
• Supplements and vitamins — including herbal products like St. John's Wort, and even high-dose caffeine supplements.
• Recent medication changes — especially if you've recently stopped an MAOI (the 14-day washout period is critical).
• Upcoming surgeries — your anesthesiologist needs to know about Jornay PM.

Also tell your pharmacist about all your medications. Pharmacists run automated interaction checks when filling prescriptions, and this is an important safety net.

Final Thoughts

Drug interactions are one of the most important safety considerations with any medication, and Jornay PM is no exception. The good news is that most interactions are manageable with proper monitoring and dose adjustments — the MAOI interaction being the critical exception (just don't do it). Stay transparent with your healthcare team about everything you take, and you'll be in good shape.

For a broader overview of this medication, including dosing and cost information, see: What Is Jornay PM? Uses, Dosage, and What You Need to Know.