How to Help Your Patients Find Onfi in Stock: A Provider's Guide

For providers managing patients with Lennox-Gastaut syndrome (LGS) and other epilepsy syndromes, the question "where can I find clobazam?" has become a recurring challenge. Onfi and generic clobazam have faced intermittent supply disruptions since around 2020, and as of 2026, availability remains inconsistent. This guide offers actionable steps to help your patients locate their medication, reduce gaps in therapy, and navigate the current access landscape.

Why This Problem Lands in Your Office

When patients can't fill their clobazam prescription, they call the prescribing office — and rightly so. Abrupt discontinuation of clobazam carries significant clinical risks including withdrawal seizures and status epilepticus. Providers are in a unique position to help: by proactively educating patients, creating contingency plans, and connecting families with access tools, you can prevent dangerous medication gaps before they happen.

Understanding the Current Supply Landscape

Clobazam is available in three formulations, each with different availability profiles in 2026:

• Generic clobazam tablets (10 mg, 20 mg): Most consistently available. Multiple generic manufacturers produce these, though localized shortages occur.
• Oral suspension (2.5 mg/mL): Most vulnerable to supply disruptions. Pediatric patients who require liquid dosing are disproportionately affected.
• Sympazan oral film: Produced by Aquestive Therapeutics; typically available via specialty pharmacy channels; may require prior authorization.

Independent pharmacies, hospital outpatient pharmacies, and specialty pharmacies generally have more consistent stock than large retail chains. Building relationships with these pharmacies — and directing your patients to them — is one of the most effective strategies available.

Step 1: Prescribe Generically and Include All Formulations

Where clinically appropriate, prescribe clobazam generically rather than specifying brand Onfi. Also consider writing the prescription to allow substitution between formulations. A note such as "clobazam tablets or equivalent formulation acceptable" gives the pharmacist and patient flexibility during shortage periods.

When oral suspension is needed for a pediatric patient, discuss in advance with the family whether a tablet that is crushed and mixed with applesauce might work as a backup — many younger patients can tolerate this approach, and it opens up the larger pool of available generic tablets.

Step 2: Direct Patients to medfinder

medfinder is a service that calls pharmacies near the patient's location to identify which ones have their medication in stock. Instead of the patient or your office staff spending time on hold, medfinder handles the calls and texts the patient the results. You can learn more about how to direct your patients at medfinder.com/providers. This can be built into your patient education workflow — a simple handout or after-visit note that says "If you have trouble finding your clobazam, use medfinder.com" can save families hours of frustration.

Step 3: Establish a Pharmacy Relationship for Your LGS Patients

If your practice manages a significant number of LGS patients, consider identifying 2–3 local independent or specialty pharmacies that reliably stock clobazam and referring your patients to them. Many independent pharmacies are willing to maintain a dedicated supply for established patient populations. This is one of the most durable solutions to recurring availability problems.

Step 4: Create a Documented Contingency Plan for Each Patient

For each clobazam-dependent patient, document in the chart:

• Their current clobazam dose and formulation
• The preferred pharmacy and an alternative pharmacy
• A pre-specified contingency: which alternative medication to transition to, at what dose, and how to taper if needed
• When to call the office urgently (e.g., fewer than 5 days of supply remaining)

This allows any member of your care team — not just the prescribing provider — to help the patient quickly when a shortage call comes in.

Step 5: Leverage Manufacturer Support Programs

Lundbeck (manufacturer of brand Onfi) and Aquestive Therapeutics (manufacturer of Sympazan) both offer provider and patient support resources:

• Lundbeck Onfi support line: 1-800-455-1141 — prior authorization assistance, bridge supply, and patient assistance
• Aquestive Therapeutics: Sympazan patient assistance and prior auth support for eligible patients
• Epilepsy Foundation: 1-800-332-1000 — connects patients with local resources and medication assistance

When to Consider Switching Formulations vs. Medications

A formulation switch (e.g., from suspension to tablets) is generally lower risk than a medication switch (e.g., from clobazam to clonazepam). When a shortage occurs:

1. First exhaust all options to find the same clobazam formulation at a different pharmacy
2. Then consider an alternative clobazam formulation (e.g., tablets when suspension is unavailable)
3. Only then consider a medication switch, and only with close monitoring

Key Takeaways for Providers

• Proactive education and planning reduce shortage-related emergencies
• Generic clobazam tablets are more reliably available than the oral suspension
• Sympazan oral film can serve as a backup for patients who need a non-tablet option
• Tools like medfinder allow patients to locate pharmacy inventory without repeated phone calls
• Document a contingency plan in each clobazam patient's chart before a shortage occurs