Cefazolin Shortage in 2026: Here's What's Happening

If you've been told your Cefazolin prescription can't be filled, you're dealing with one of the longest-running drug shortages in the United States. Cefazolin — the injectable antibiotic formerly sold as Ancef and Kefzol — has been on and off the FDA and ASHP drug shortage lists since 2010.

This article breaks down the current state of the Cefazolin shortage in 2026, why it's happening, what it costs, and most importantly, what you can do about it.

Is Cefazolin Still in Shortage?

As of early 2026, Cefazolin continues to experience intermittent supply disruptions. While the shortage is not as severe as the 2019-2020 period — when multiple manufacturers had simultaneous production issues — availability remains inconsistent depending on your region, pharmacy type, and the specific Cefazolin formulation you need.

Some key facts:

• Powder vials (500 mg, 1 g, 2 g) have been more reliably available than premixed bags
• Premixed frozen solutions (1 g/50 mL and 2 g/50 mL in dextrose) have been more frequently affected by shortages
• Availability varies significantly by region — urban hospitals typically have better access than rural facilities
• Multiple manufacturers (Hikma, Sandoz, Sagent, WG Critical Care, Baxter) produce Cefazolin, which helps buffer against total stockouts

Why Is Cefazolin Hard to Find?

The Cefazolin shortage stems from several interconnected factors:

Manufacturing Complexity

Sterile injectable drugs require specialized manufacturing facilities that must meet rigorous FDA standards. Production disruptions — from equipment failures to contamination events to routine maintenance shutdowns — can knock a production line offline for weeks or months.

Limited Manufacturers

Only a handful of companies make Cefazolin for the U.S. market. When one manufacturer has a disruption, the others can't always scale up quickly enough to cover the gap.

Supply Chain Vulnerabilities

The active pharmaceutical ingredient (API) for Cefazolin is primarily manufactured overseas. Global supply chain issues — including shipping delays, geopolitical tensions, and quality problems at API facilities — contribute to inconsistent supply.

Economic Factors

Generic injectable antibiotics like Cefazolin sell for very low prices ($5 to $15 per vial at acquisition cost). These thin profit margins discourage manufacturers from investing in additional production capacity. For a deeper dive, read Why Is Cefazolin So Hard to Find?

How Much Does Cefazolin Cost in 2026?

Cefazolin pricing depends on where and how you receive it:

• Hospital setting: If you receive Cefazolin during a hospital stay or in an outpatient infusion center, the drug cost is typically bundled into your facility charges. Your out-of-pocket cost depends on your insurance coverage and deductible.
• Home infusion: For patients receiving Cefazolin through home infusion, the cash price for a single 1 g vial ranges from approximately $5 to $30. However, home infusion services also include supplies (IV tubing, saline, pumps) and nursing visits, which add to the total cost.
• Premixed bags: Premixed Cefazolin in dextrose bags cost approximately $15 to $50 each, depending on the dose and supplier.
• Full course of treatment: A typical course of IV Cefazolin (e.g., for a skin infection or post-surgical prophylaxis) can cost $50 to $500+ out of pocket, depending on the duration, dosing frequency, and pharmacy.

For tips on reducing your costs, see How to Save Money on Cefazolin in 2026.

Are There New Options for Getting Cefazolin?

Several developments in recent years have improved access:

• Additional manufacturers: The FDA has worked to bring more manufacturers online for critical injectable antibiotics, helping to diversify the supply base.
• Hospital stockpiling programs: Some hospital systems have implemented strategic stockpiling to buffer against shortages of critical drugs like Cefazolin.
• Real-time tracking tools: Services like Medfinder now let patients and providers check Cefazolin availability in real time, reducing the guesswork.
• Home infusion growth: The expansion of home infusion pharmacy services means more patients can access IV antibiotics outside of the hospital setting.

How to Find Cefazolin in Stock

If you need Cefazolin right now, here are your best steps:

1. Use Medfinder to check real-time availability near you
2. Call specialty and home infusion pharmacies — they often have different supply channels than retail chains
3. Ask your hospital's pharmacy — institutional pharmacies may have access through different distributors
4. Contact independent pharmacies — they may source from wholesalers that still have stock
5. Talk to your doctor about alternatives — if Cefazolin truly isn't available, antibiotics like Ceftriaxone, Cephalexin, or Nafcillin may be appropriate substitutes

For detailed strategies, read How to Find Cefazolin in Stock Near You.

Final Thoughts

The Cefazolin shortage is a frustrating reality that shows no signs of fully resolving in 2026. The underlying issues — limited manufacturers, thin profit margins, and supply chain fragility — are systemic problems in the generic injectable drug market.

But as a patient, you're not powerless. Tools like Medfinder can help you locate available supply, and your healthcare team can help you find effective alternatives if needed. Stay informed, advocate for yourself, and don't delay treatment because of supply issues.

For the provider perspective on this shortage, see Cefazolin Shortage: What Providers and Prescribers Need to Know.