Azasite Shortage Update: What's Happening in 2026?

If you've tried to fill a prescription for Azasite (Azithromycin ophthalmic solution 1%) recently and hit a wall, you're probably wondering: is there an actual Azasite shortage? The answer is nuanced — and in this article, we'll give you the full picture on what's going on with Azasite supply in 2026, why it's hard to find, what it costs, and what you can do about it.

Is Azasite Still in Shortage?

As of late 2025, the FDA reported that Azasite is currently available. The product — Azithromycin ophthalmic solution 1%, 2.5 mL in 5 mL bottle (NDC 17478-307-03) — is being manufactured and distributed. So technically, there is no formal FDA-listed shortage of Azasite.

However, practical availability is a different story. Many patients report difficulty finding Azasite because:

• It's only available through the EyeRx Direct specialty pharmacy program
• Most retail pharmacies don't carry it and can't order it through their usual channels
• Demand has increased significantly due to the ongoing erythromycin ophthalmic ointment shortage

So while supply exists, the distribution model creates an availability gap that feels like a shortage to many patients.

Why Is Azasite Hard to Find?

Several factors contribute to the limited availability of Azasite in 2026:

Specialty-Only Distribution

Azasite is not sold through standard retail pharmacy channels. It's distributed exclusively through EyeRx Direct at azasite.com. This means that even if your doctor prescribes it, your local CVS, Walgreens, or Walmart likely can't fill it.

No Generic Competition

There is no generic version of Azasite on the market. This means the entire supply comes from a single source, making it vulnerable to any production or distribution disruptions. For more on why this matters, see: Why is Azasite so hard to find?

Erythromycin Shortage Spillover

The ongoing national shortage of erythromycin ophthalmic ointment has had a direct impact on Azasite demand. The FDA, CDC, and American Academy of Ophthalmology have recommended Azasite as an alternative for treating superficial ocular infections. This surge in prescriptions has strained an already narrow supply chain.

Manufacturer Transitions

Azasite's manufacturing has changed hands multiple times — from InSite Vision to Inspire Pharmaceuticals, then to Akorn, and most recently to Sun Pharma following Akorn's bankruptcy in 2023. These transitions can disrupt production schedules and distribution networks.

What Does Azasite Cost in 2026?

Azasite is one of the more expensive antibiotic eye drops on the market:

• Retail cash price: $259–$300 for a single 2.5 mL bottle
• With GoodRx coupon: approximately $205
• Through EyeRx Direct: approximately $60 per bottle — the best available price

Since there's no generic, patients pay brand-name prices regardless of insurance status. Some insurance plans cover Azasite, but many require prior authorization or step therapy (trying a cheaper alternative first). For detailed savings strategies, read: How to save money on Azasite.

Are There New Options for Treating Bacterial Conjunctivitis?

While no new azithromycin ophthalmic product has entered the market, patients and providers have several proven alternatives:

• Moxifloxacin (Vigamox) — a fluoroquinolone eye drop, generic available for $15–$30
• Tobramycin (Tobrex) — an aminoglycoside eye drop, generic available for $10–$20
• Polytrim — a combination antibiotic eye drop, generic available for $10–$15

These alternatives are effective against most bacteria causing conjunctivitis and are widely available at retail pharmacies. See our full comparison: Alternatives to Azasite.

How to Find Azasite in Stock Right Now

If you need Azasite specifically, here's what to do:

1. Search on Medfinder: Use Medfinder to check which pharmacies near you have Azasite available
2. Use EyeRx Direct: Visit azasite.com and have your doctor send the prescription to the specialty pharmacy program
3. Ask your prescriber: Ophthalmologists and optometrists are often familiar with the EyeRx Direct program and can help navigate the process
4. Call independent pharmacies: Some independent pharmacies have relationships with specialty distributors

For more strategies, read: How to find Azasite in stock near you.

Final Thoughts

While Azasite is not technically in an FDA-listed shortage in 2026, its specialty-only distribution, lack of generic, manufacturer changes, and spillover demand from the erythromycin shortage make it genuinely hard to find for many patients. The key is knowing where to look — the EyeRx Direct program remains the most reliable source — and being aware that effective, affordable alternatives exist.

If you're struggling to find or afford Azasite, use Medfinder to search availability and talk to your doctor about your options. Prompt treatment of bacterial conjunctivitis is important, so don't delay getting the care you need.