Comprehensive medication guide to Seasonique including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0 copay for generic extended-cycle levonorgestrel/ethinyl estradiol on most ACA-compliant plans under the contraceptive mandate; Tier 1–2 coverage for generics, with potential copay for brand-name Seasonique.
Estimated Cash Pricing
$490–$515 retail for brand Seasonique; as low as $21–$50 with GoodRx or SingleCare coupons for generic equivalents (Amethia, Ashlyna, Camrese, Daysee, Jaimiess, Simpesse) for a 91-day supply.
Medfinder Findability Score
62/100
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Seasonique is an extended-cycle combination oral contraceptive manufactured by Teva Pharmaceuticals. It contains levonorgestrel (0.15 mg, a synthetic progestin) and ethinyl estradiol (0.03 mg, a synthetic estrogen) in 84 active tablets, followed by 7 low-dose estrogen tablets containing ethinyl estradiol 0.01 mg only. This 91-day cycle design gives patients approximately four periods per year instead of twelve.
Seasonique is FDA-approved for prevention of pregnancy and is one of the most prescribed extended-cycle oral contraceptives in the United States. It is not a controlled substance and can be prescribed by any licensed healthcare provider. Six AB-rated generic equivalents are available: Amethia, Ashlyna, Camrese, Daysee, Jaimiess, and Simpesse.
Beyond contraception, Seasonique is commonly used off-label for endometriosis management, dysmenorrhea (painful periods), premenstrual dysphoric disorder (PMDD), and PCOS symptom management. The reduced frequency of withdrawal bleeds limits hormonal fluctuations that can worsen these conditions.
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Seasonique prevents pregnancy through three mechanisms. The primary mechanism is suppression of ovulation: levonorgestrel and ethinyl estradiol suppress the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Without the LH surge, the ovaries do not release an egg. No egg means no fertilization.
Second, levonorgestrel thickens cervical mucus, making it physically difficult for sperm to travel toward an egg. Third, both hormones alter the endometrial lining, reducing receptivity to implantation. The 84-day continuous active hormone phase suppresses ovulation throughout the entire cycle, and the final 7 days of low-dose estrogen (rather than placebo) help minimize breakthrough bleeding and withdrawal symptoms during the scheduled period.
Both hormones are metabolized by the CYP3A4 enzyme system in the liver. Medications that induce CYP3A4 — such as rifampin, certain seizure medications, and St. John's Wort — can reduce contraceptive effectiveness by accelerating hormone breakdown. Backup contraception should be used when taking CYP3A4 inducers.
0.15 mg levonorgestrel / 0.03 mg ethinyl estradiol + 0.01 mg ethinyl estradiol — Extended-cycle oral tablets (91-count pack)
84 light blue-green active tablets (LNG 0.15 mg / EE 0.03 mg) + 7 yellow low-dose EE tablets (EE 0.01 mg). One tablet daily for 91 days.
Seasonique is not on the FDA Drug Shortage Database as of 2026, but real-world availability is inconsistent. Because Seasonique is dispensed as a 91-day supply (refilled only four times per year), many pharmacy inventory algorithms do not prioritize stocking it — especially at large chain pharmacies. Independent pharmacies and mail-order pharmacies often have better availability.
Extended-cycle oral contraceptives as a class experienced supply disruptions starting in 2022 due to manufacturing consolidation, raw material sourcing issues, and growing demand. While the situation has improved, patients in some regions continue to report difficulty finding Seasonique or specific generics at their local pharmacy.
If you're struggling to find Seasonique, medfinder calls pharmacies near you to check which ones have it in stock and texts you the results — saving you hours of calls and failed pharmacy trips.
Seasonique is not a controlled substance and has no DEA scheduling requirements. Any licensed prescriber can write a prescription for Seasonique or its generics. No specialist referral, special prescribing license, or DEA registration is required beyond a standard prescriber license.
Telehealth is widely available for Seasonique prescriptions. Platforms including Wisp, Pandia Health, Nurx, and Hello Alpha can prescribe Seasonique or a generic equivalent via an online consultation, often the same day, and send the prescription directly to your pharmacy or by mail.
No. Seasonique is not a controlled substance and is not scheduled by the DEA. It is a standard prescription oral contraceptive that can be prescribed by any licensed healthcare provider — including primary care physicians, OB/GYNs, nurse practitioners, physician assistants, and telehealth providers.
There are no DEA prescribing requirements, no mandatory drug monitoring programs, no quantity limits tied to scheduling, and no restrictions on electronic prescribing. Prescriptions for Seasonique or its generics can be sent electronically to any pharmacy, including mail-order pharmacies, without special authorization.
The most common side effects reported in clinical trials (≥5% of participants) were:
Other commonly reported side effects include nausea, breast tenderness, headaches, mood changes, and spotting between scheduled periods.
Seek emergency medical attention immediately for:
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Seasonale / Jolessa / Quasense
Same 84/7 extended-cycle design with identical active hormone doses but uses inert placebo tablets in the final 7 days rather than low-dose estrogen. May cause more breakthrough bleeding during the final week for some patients.
Lo Seasonique / Amethia Lo / Camrese Lo
Lower-dose variant of the Seasonique formulation: LNG 0.10 mg / EE 0.02 mg for 84 days + EE 0.01 mg for 7 days. Same extended-cycle schedule with reduced estrogen; may suit patients sensitive to estrogen side effects.
Amethyst (continuous-cycle)
Continuous-cycle levonorgestrel/ethinyl estradiol — taken every day with no hormone-free interval. Eventually leads to amenorrhea for most patients rather than four periods per year.
Mirena IUD
Hormonal IUD lasting up to 8 years. Significantly reduces or eliminates periods for most users. Supply-independent, no daily pill required. For patients struggling with repeated Seasonique refill challenges, a LARC may be a practical long-term solution.
Prefer Seasonique? We can find it.
Rifampin (Rifadin)
majorPowerful CYP3A4 inducer. Dramatically reduces levonorgestrel and ethinyl estradiol levels. Significantly increases risk of contraceptive failure. Use reliable backup contraception throughout rifampin treatment and for 28 days after stopping.
St. John's Wort
majorCYP3A4 enzyme inducer. Reduces hormonal contraceptive effectiveness. FDA has specifically warned of breakthrough bleeding and potential failure. Do not use while taking Seasonique.
Ombitasvir/paritaprevir/ritonavir (Viekira Pak)
majorCONTRAINDICATED. Co-administration can cause ALT elevations >5x ULN. Discontinue Seasonique at least 2 weeks before starting this HCV regimen.
Glecaprevir/pibrentasvir (Mavyret)
majorCo-administration not recommended due to potential for ALT elevations.
Phenytoin (Dilantin) / Carbamazepine (Tegretol) / Phenobarbital
majorCYP3A4-inducing antiepileptics. Reduce contraceptive hormone levels. May require non-hormonal contraceptive method. Consult with neurologist before switching contraception.
Lamotrigine (Lamictal)
moderateCOCs significantly decrease lamotrigine plasma levels through induction of glucuronidation. Can reduce seizure control. Dose adjustment may be needed — consult prescribing provider.
Atorvastatin (Lipitor)
minorMay increase ethinyl estradiol AUC by approximately 20%. Monitor for increased estrogen-related side effects (nausea, breast tenderness).
Acetaminophen (Tylenol)
minorMay increase plasma ethinyl estradiol concentrations by inhibiting conjugation. Effect is generally minor and clinically insignificant at standard doses.
Seasonique is a well-established, effective extended-cycle oral contraceptive that gives patients four periods per year. Its unique formulation — using low-dose estrogen rather than placebo in the final 7 days — makes it distinctive among extended-cycle options, with generally lower rates of breakthrough bleeding than Seasonale.
The main challenge for patients in 2026 is not effectiveness or safety — it is finding it in stock. With six AB-rated generics available, the best strategy is to have a prescription written generically, allowing pharmacists maximum flexibility to dispense whichever equivalent is in stock and covered.
If you're struggling to find Seasonique or a generic equivalent near you, medfinder searches pharmacies near you to find which ones can fill your prescription — so you can stop calling and start filling.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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