Comprehensive medication guide to Reyvow including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
With commercial insurance and the Lilly Savings Card, eligible patients may pay as little as $0 per fill, though most insured patients can expect a copay of $30 to $75 after prior authorization.
Estimated Cash Pricing
Without insurance, Reyvow typically costs between $850 and $1,100 for a supply of 8 tablets at most retail pharmacies.
Medfinder Findability Score
25/100
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Reyvow (Lasmiditan) is a prescription medication approved for the acute treatment of migraine with or without aura in adults. It belongs to a class of drugs called ditans, which work differently from triptans. Reyvow is taken as a single tablet at the onset of a migraine attack. It is a Schedule V controlled substance, meaning it has a low potential for misuse. Importantly, Eli Lilly has announced that Reyvow is being permanently discontinued, with U.S. distribution ending May 31, 2026.
Reyvow selectively activates serotonin 5-HT1F receptors in the brain. By targeting these receptors, it inhibits neuronal firing and reduces the release of neuropeptides involved in the trigeminal pain pathway — the system responsible for migraine pain. Unlike triptans (such as Sumatriptan), Reyvow does cause vasoconstriction (narrowing of blood vessels), which made it a valuable option for migraine patients with cardiovascular risk factors. However, it can cause significant dizziness and sedation, and patients must not drive or operate machinery for at least 8 hours after taking a dose.
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50 mg oral tablet — tablet
100 mg oral tablet — tablet
Reyvow (Lasmiditan) has been permanently discontinued by Eli Lilly. The manufacturer announced a voluntary global discontinuation in late 2025, and U.S. distribution is expected to end by May 31, 2026. This is a business decision — not related to safety or quality concerns. While some pharmacies may still have remaining inventory, supply is rapidly declining. Patients currently taking Reyvow should work with their prescriber to transition to an alternative acute migraine treatment as soon as possible. Medfinder can help you locate any remaining stock near you.
Reyvow is most commonly prescribed by neurologists and headache specialists, but it can also be prescribed by primary care physicians, internists, and family medicine doctors. If you currently take Reyvow and need help transitioning to an alternative before the discontinuation date, your prescriber is the best place to start.
Yes. Reyvow is classified as a Schedule V (C-V) controlled substance by the DEA, the lowest level of controlled substance scheduling. This classification is due to Reyvow's potential to cause feelings of euphoria and sedation. Schedule V status means prescriptions may have additional restrictions depending on your state, including limits on refills and requirements for in-person prescriber visits.
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Ubrelvy (Ubrogepant)
An oral CGRP receptor antagonist (gepant) for acute migraine. Not a controlled substance and does not impair driving.
Nurtec ODT (Rimegepant)
An orally disintegrating CGRP antagonist that can be used for both acute treatment and prevention of migraine.
Zavzpret (Zavegepant)
A CGRP antagonist nasal spray for acute migraine with fast onset of action.
Sumatriptan
A generic triptan and first-line acute migraine treatment. Very affordable, but causes vasoconstriction and is not suitable for patients with cardiovascular disease.
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Serotonergic drugs
moderate(SSRIs, SNRIs, TCAs, MAOIs, Trazodone) — Risk of serotonin syndrome, a potentially life-threatening condition.
P-glycoprotein substrates
moderate(Dabigatran, Digoxin) — Reyvow inhibits P-gp and may increase levels of these drugs.
BCRP substrates
moderate(Rosuvastatin) — Reyvow inhibits BCRP and may increase statin exposure.
Alcohol and CNS depressants
moderateEnhanced drowsiness, dizziness, and impairment.
Heart rate-lowering medications
moderateMay potentiate bradycardia (slow heart rate).
Reyvow was a first-in-class migraine treatment that offered a unique non-vasoconstrictive option for patients who couldn't safely use triptans. Unfortunately, Eli Lilly's decision to permanently discontinue the drug means patients need to act now. If you're currently taking Reyvow, talk to your doctor about switching to an alternative such as Ubrelvy, Nurtec ODT, or Zavzpret before remaining pharmacy stock runs out. Use Medfinder to locate any remaining Reyvow inventory near you while supplies last.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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